7alpha-Hydroxycholesterol

7alpha-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7alpha-hydroxycholesterol is associated with abnormalities such as Atherosclerosis, Morphologically altered structure, Carotid Atherosclerosis, Myocardial Infarction and Cerebrovascular accident. The involved functions are known as Apoptosis, Cell Growth, Necrosis, Chromosome Condensation and Tissue Adhesions. 7alpha-hydroxycholesterol often locates in Arterial system, Endothelium, Cell Nucleus, Membrane and yolk. The associated genes with 7alpha-Hydroxycholesterol are acetyl-aspartyl-glutamyl-valyl-aspartal, BCL2 gene, OGFR gene, Genome and GAPDH gene. The related lipids are Hydroxycholesterols, 7-ketocholesterol, Ketocholesterols, 20-hydroxycholesterol and 25-hydroxycholesterol.

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Introduction

To understand associated biological information of 7alpha-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 7alpha-Hydroxycholesterol?

7alpha-Hydroxycholesterol is suspected in Kozlowski Celermajer Tink syndrome, Atherosclerosis, Carotid Atherosclerosis, Xanthomatosis, Cerebrotendinous, Keratoconjunctivitis Sicca, Fatty Streak, Arterial and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 7alpha-Hydroxycholesterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Carotid Stenosis D016893 15 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with 7alpha-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 7alpha-Hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 7alpha-Hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 7alpha-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 7alpha-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 7alpha-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 7alpha-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
Cho HR et al. 7-Oxygenated cholesterol molecules differentially affect the expression of zonula occludens-1 in vascular smooth muscle cells and monocyte/macrophage cells. 2018 Biochem. Biophys. Res. Commun. pmid:29428726
Cho HR et al. 7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor. 2017 PLoS ONE pmid:28323848
Deiana M et al. Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. 2017 Free Radic. Biol. Med. pmid:29102636
Stellaard F et al. The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. 2017 J. Steroid Biochem. Mol. Biol. pmid:27060336
Park SH et al. α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy. 2017 Oncotarget pmid:28088783
Keune WJ et al. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. 2016 Nat Commun pmid:27075612
Musman J et al. Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. 2016 Free Radic. Biol. Med. pmid:27989751
Park SH et al. Dietary compound α-asarone alleviates ER stress-mediated apoptosis in 7β-hydroxycholesterol-challenged macrophages. 2016 Mol Nutr Food Res pmid:26893256
Pataj Z et al. Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. 2016 J Chromatogr A pmid:26607314
Rasmiena AA et al. High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein. 2016 Biochim. Biophys. Acta pmid:26569052