4beta-Hydroxycholesterol

4beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 4beta-hydroxycholesterol is associated with abnormalities such as Kidney Failure, Kidney Failure, Chronic, Respiratory Tract Infections, Immunologic Deficiency Syndromes and Infection. The involved functions are known as Selection, Genetic, Renal function, Anabolism, Inflammation and Cell division phases. 4beta-hydroxycholesterol often locates in Hepatic, Blood, Skin and Microsomes. The associated genes with 4beta-Hydroxycholesterol are CYP3A5 gene, Alleles, TERT gene, CYP3A4 gene and CYP3A7 gene. The related lipids are 4-hydroxycholesterol, Hydroxycholesterols, Promega, Pregnanes and 24-hydroxycholesterol.

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Introduction

To understand associated biological information of 4beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4beta-Hydroxycholesterol?

4beta-Hydroxycholesterol is suspected in Kidney Failure, Chronic, Kidney Failure, Respiratory Tract Infections, Immunologic Deficiency Syndromes, Infection, Epilepsy and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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PubChem Associated disorders and diseases

What pathways are associated with 4beta-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4beta-Hydroxycholesterol?

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What functions are associated with 4beta-Hydroxycholesterol?


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What lipids are associated with 4beta-Hydroxycholesterol?

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What genes are associated with 4beta-Hydroxycholesterol?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4beta-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4beta-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
Diczfalusy U et al. 4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin. 2009 Br J Clin Pharmacol pmid:19006545
Tomalik-Scharte D et al. Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric? 2009 Clin. Pharmacol. Ther. pmid:19458613
Allmyr M et al. Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19686543
Lütjohann D et al. 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. 2009 Int J Clin Pharmacol Ther pmid:19954708
Yang Z and Rodrigues AD Does the long plasma half-life of 4beta-hydroxycholesterol impact its utility as a cytochrome P450 3A (CYP3A) metric? 2010 J Clin Pharmacol pmid:20197489
Gebeyehu E et al. Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians. 2011 Pharmacogenomics J. pmid:20231858
Diczfalusy U et al. 4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans. 2011 Br J Clin Pharmacol pmid:21219398
Nylén H et al. Cytochrome P450 3A activity in mothers and their neonates as determined by plasma 4β-hydroxycholesterol. 2011 Eur. J. Clin. Pharmacol. pmid:21246351
van de Merbel NC et al. A validated liquid chromatography-tandem mass spectrometry method for the quantitative determination of 4β-hydroxycholesterol in human plasma. 2011 J Pharm Biomed Anal pmid:21507593
Peters J et al. Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals. 2011 Drug Metab. Dispos. pmid:21690264