4beta-Hydroxycholesterol

4beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 4beta-hydroxycholesterol is associated with abnormalities such as Kidney Failure, Kidney Failure, Chronic, Respiratory Tract Infections, Immunologic Deficiency Syndromes and Infection. The involved functions are known as Selection, Genetic, Renal function, Anabolism, Inflammation and Cell division phases. 4beta-hydroxycholesterol often locates in Hepatic, Blood, Skin and Microsomes. The associated genes with 4beta-Hydroxycholesterol are CYP3A5 gene, Alleles, TERT gene, CYP3A4 gene and CYP3A7 gene. The related lipids are 4-hydroxycholesterol, Hydroxycholesterols, Promega, Pregnanes and 24-hydroxycholesterol.

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Introduction

To understand associated biological information of 4beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4beta-Hydroxycholesterol?

4beta-Hydroxycholesterol is suspected in Kidney Failure, Chronic, Kidney Failure, Respiratory Tract Infections, Immunologic Deficiency Syndromes, Infection, Epilepsy and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 4beta-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4beta-Hydroxycholesterol?

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What functions are associated with 4beta-Hydroxycholesterol?


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What lipids are associated with 4beta-Hydroxycholesterol?

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What genes are associated with 4beta-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4beta-Hydroxycholesterol?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4beta-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
Wide K et al. Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsy. 2008 Br J Clin Pharmacol pmid:18279471
Vanhove T et al. Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance. 2016 Br J Clin Pharmacol pmid:27501475
Diczfalusy U et al. 4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans. 2011 Br J Clin Pharmacol pmid:21219398
Diczfalusy U et al. 4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin. 2009 Br J Clin Pharmacol pmid:19006545
Higashi T et al. LC/MS/MS of steroids having vicinal diol as electrospray-active boronates. 2013 Chem. Pharm. Bull. pmid:23449202
Goodenough AK et al. Quantification of 4-beta-hydroxycholesterol in human plasma using automated sample preparation and LC-ESI-MS/MS analysis. 2011 Chem. Res. Toxicol. pmid:21728364
DeGorter MK et al. Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care. 2013 Circ Cardiovasc Genet pmid:23876492
Jiang X et al. An Exposure-Response Modeling Approach to Examine the Relationship Between Potency of CYP3A Inducer and Plasma 4β-Hydroxycholesterol in Healthy Subjects. 2017 Clin Pharmacol Drug Dev pmid:27138546
Wollmann BM et al. 4β-Hydroxycholesterol Level in Patients With Rheumatoid Arthritis Before vs. After Initiation of bDMARDs and Correlation With Inflammatory State. 2017 Clin Transl Sci pmid:27991741
Shin KH et al. Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance. 2013 Clin. Pharmacol. Ther. pmid:23784264