4-Cholesten-3-one

4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.

Cross Reference

Introduction

To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-Cholesten-3-one?

4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 4-Cholesten-3-one

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-Cholesten-3-one?

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What functions are associated with 4-Cholesten-3-one?


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What lipids are associated with 4-Cholesten-3-one?

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What genes are associated with 4-Cholesten-3-one?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-Cholesten-3-one?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-Cholesten-3-one

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Authors Title Published Journal PubMed Link
pmid:
Pang L et al. Membrane cholesterol modulates galanin-GalR2 interaction. 1999 Biochemistry pmid:10508403
Weststrate JA et al. Safety evaluation of phytosterol esters. Part 4. Faecal concentrations of bile acids and neutral sterols in healthy normolipidaemic volunteers consuming a controlled diet either with or without a phytosterol ester-enriched margarine. 1999 Food Chem. Toxicol. pmid:10566877
Liu P et al. Presence of oxidized cholesterol in caveolae uncouples active platelet-derived growth factor receptors from tyrosine kinase substrates. 2000 J. Biol. Chem. pmid:10918056
Nam RK et al. V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progression. 2001 Urology pmid:11164181
Platz EA Basic Science. 2001 Urology pmid:11273573
DellaGreca M et al. Solid-state photodimerization of cholest-4-en-3-one. 2001 J. Org. Chem. pmid:11300900
Charbonneau A and The VL Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme. 2001 Biochim. Biophys. Acta pmid:11342103
Fritsch M et al. Sebocytes are the key regulators of androgen homeostasis in human skin. 2001 J. Invest. Dermatol. pmid:11348472
Wu AH et al. Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men. 2001 Cancer Epidemiol. Biomarkers Prev. pmid:11352865