| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ghosh S et al. | Cholesterol-oxidase-magnetic nanobioconjugates for the production of 4-cholesten-3-one and 4-cholesten-3, 7-dione. | 2018 | Bioresour. Technol. | pmid:29413944 |
| Donato LJ et al. | Description of analytical method and clinical utility of measuring serum 7-alpha-hydroxy-4-cholesten-3-one (7aC4) by mass spectrometry. | 2018 | Clin. Biochem. | pmid:29051033 |
| Chen CL et al. | Cholest-4-en-3-one attenuates TGF-β responsiveness by inducing TGF-β receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells. | 2017 | J. Recept. Signal Transduct. Res. | pmid:27401208 |
| Chen L et al. | A new ent-kaurane diterpenoid from Ixora amplexicaulis. | 2016 | Nat. Prod. Res. | pmid:25941744 |
| Ma J et al. | 4-cholesten-3-one suppresses lung adenocarcinoma metastasis by regulating translocation of HMGB1, HIF1α and Caveolin-1. | 2016 | Cell Death Dis | pmid:27899819 |
| Mouzaki M et al. | Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease. | 2016 | PLoS ONE | pmid:27203081 |
| Chen M et al. | The rate-determining steps of aldo-keto reductases (AKRs), a study on human steroid 5β-reductase (AKR1D1). | 2015 | Chem. Biol. Interact. | pmid:25500266 |
| Lin CW et al. | Substrate uptake and subcellular compartmentation of anoxic cholesterol catabolism in Sterolibacterium denitrificans. | 2015 | J. Biol. Chem. | pmid:25418128 |
| Walters JR et al. | The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid. | 2015 | Aliment. Pharmacol. Ther. | pmid:25329562 |
| Benesch MG et al. | A DSC and FTIR spectroscopic study of the effects of the epimeric 4-cholesten-3-ols and 4-cholesten-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: comparison with their 5-cholesten analogues. | 2014 | Chem. Phys. Lipids | pmid:24296232 |
| Neuvonen M et al. | Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. | 2014 | PLoS ONE | pmid:25157633 |
| Bouvaine S et al. | A dietary test of putative deleterious sterols for the aphid Myzus persicae. | 2014 | PLoS ONE | pmid:24465993 |
| GarcÃa-Fernández E et al. | A highly conserved mycobacterial cholesterol catabolic pathway. | 2013 | Environ. Microbiol. | pmid:23489718 |
| Lange Y et al. | Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. | 2012 | PLoS ONE | pmid:22276143 |
| Chen DM et al. | [The relationship of serum testosterone and its related index with the metabolism syndrome in women at perimenopausal or postmenopausal periods]. | 2012 | Zhonghua Fu Chan Ke Za Zhi | pmid:22455743 |
| Pan L et al. | Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii. | 2012 | Phytochemistry | pmid:22840389 |
| Martel C et al. | Inhibition of the Mitochondrial Permeability Transition for Cytoprotection: Direct versus Indirect Mechanisms. | 2012 | Biochem Res Int | pmid:22675634 |
| Biswas A et al. | Influence of pioglitazone on experimental heart failure and hyperlipidemia in rats. | 2012 | Indian J Pharmacol | pmid:22701242 |
| Jusakul A et al. | Liver fluke-induced hepatic oxysterols stimulate DNA damage and apoptosis in cultured human cholangiocytes. | 2012 | Mutat. Res. | pmid:22044627 |
| Djavan B et al. | Testosterone in prostate cancer: the Bethesda consensus. | 2012 | BJU Int. | pmid:22129242 |
| Cieślak J et al. | Convenient and efficient approach to the permanent or reversible conjugation of RNA and DNA sequences with functional groups. | 2012 | Curr Protoc Nucleic Acid Chem | pmid:22956458 |
| Muto A et al. | Detection of Δ4-3-oxo-steroid 5β-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22695323 |
| Kasashima S et al. | Expression of 5α-reductase in apocrine carcinoma of the breast and its correlation with clinicopathological aggressiveness. | 2012 | Histopathology | pmid:22486281 |
| Magalon K et al. | Olesoxime accelerates myelination and promotes repair in models of demyelination. | 2012 | Ann. Neurol. | pmid:22367994 |
| Marques MP et al. | Continuous steroid biotransformations in microchannel reactors. | 2012 | N Biotechnol | pmid:22008387 |
| Yarrow JF et al. | Intracrine and myotrophic roles of 5α-reductase and androgens: a review. | 2012 | Med Sci Sports Exerc | pmid:21988936 |
| Wollam J et al. | A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. | 2012 | PLoS Biol. | pmid:22505847 |
| Joo SH et al. | Biosynthesis of a cholesterol-derived brassinosteroid, 28-norcastasterone, in Arabidopsis thaliana. | 2012 | J. Exp. Bot. | pmid:22170941 |
| Kumar M et al. | Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. | 2012 | Exp Diabetes Res | pmid:22611376 |
| Nicholson TM and Ricke WA | Androgens and estrogens in benign prostatic hyperplasia: past, present and future. | 2011 Nov-Dec | Differentiation | pmid:21620560 |
| Aggarwal S et al. | QSAR studies on human 5alpha-reductase inhibitors: unsaturated 3-carboxysteroids. | 2011 May-Jun | Acta Pol Pharm | pmid:21648201 |
| Bortolato M et al. | Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments. | 2011 | Neuropharmacology | pmid:21256141 |
| Li J et al. | Androgen regulation of 5α-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention. | 2011 | PLoS ONE | pmid:22194926 |
| UhÃa I et al. | Initial step in the catabolism of cholesterol by Mycobacterium smegmatis mc2 155. | 2011 | Environ. Microbiol. | pmid:21208358 |
| DuÅ¡ková M and PospÃÅ¡ilová H | The role of non-aromatizable testosterone metabolite in metabolic pathways. | 2011 | Physiol Res | pmid:21114370 |
| Mieczkowska J et al. | Changes in the activity of connective tissue matrix enzymes in the metabolic syndrome. | 2011 | Arch Med Sci | pmid:22291799 |
| Husain GM et al. | Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats. | 2011 | ISRN Pharmacol | pmid:22084716 |
| Paris JJ et al. | Inhibition of 5α-reductase activity in late pregnancy decreases gestational length and fecundity and impairs object memory and central progestogen milieu of juvenile rat offspring. | 2011 | J. Neuroendocrinol. | pmid:21914008 |
| Askarova S et al. | Impacts of membrane biophysics in Alzheimer's disease: from amyloid precursor protein processing to aβ Peptide-induced membrane changes. | 2011 | Int J Alzheimers Dis | pmid:21547213 |
| Martin LJ et al. | The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation. | 2011 | J. Neurosci. | pmid:21209222 |
| DeBarber AE et al. | Profiling sterols in cerebrotendinous xanthomatosis: utility of Girard derivatization and high resolution exact mass LC-ESI-MS(n) analysis. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21168372 |
| Arellano Y et al. | New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors. | 2011 | Steroids | pmid:21729714 |
| Chen L et al. | [Active ingredients of Plastrum Testudinis inhibit epidermal stem cell apoptosis in serum-deprived culture]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:21849150 |
| de Almeida CL et al. | Bioactivities from marine algae of the genus Gracilaria. | 2011 | Int J Mol Sci | pmid:21845096 |
| Lei H et al. | [Sterols of marine bryozoan Bugula neritina from the South China Sea]. | 2011 | Zhong Yao Cai | pmid:21823470 |
| Wu YG et al. | Testosterone, not 5α-dihydrotestosterone, stimulates LRH-1 leading to FSH-independent expression of Cyp19 and P450scc in granulosa cells. | 2011 | Mol. Endocrinol. | pmid:21273442 |
| Roth MY et al. | Steady-state pharmacokinetics of oral testosterone undecanoate with concomitant inhibition of 5α-reductase by finasteride. | 2011 | Int. J. Androl. | pmid:20969601 |
| Sato K et al. | Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21285401 |
| Graupp M et al. | Association of genetic variants in the two isoforms of 5α-reductase, SRD5A1 and SRD5A2, in lean patients with polycystic ovary syndrome. | 2011 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:21530059 |
| Kang HJ et al. | The first successful paternity through in vitro fertilization-intracytoplasmic sperm injection with a man homozygous for the 5α-reductase-2 gene mutation. | 2011 | Fertil. Steril. | pmid:21334614 |
| Cai LQ et al. | 17α-Estradiol and genistein inhibit high fat diet induced prostate gene expression and prostate growth in the rat. | 2011 | J. Urol. | pmid:21855913 |
| Niu Y et al. | Reduced levels of 5-α reductase 2 in adult prostate tissue and implications for BPH therapy. | 2011 | Prostate | pmid:21308715 |
| Cha EK and Shariat SF | The use of 5α-reductase inhibitors for the prevention and treatment of prostate cancer. | 2011 | Eur. Urol. | pmid:21277077 |
| Ho CK and Habib FK | Estrogen and androgen signaling in the pathogenesis of BPH. | 2011 | Nat Rev Urol | pmid:21228820 |
| Finelli A et al. | Impact of 5α-reductase inhibitors on men followed by active surveillance for prostate cancer. | 2011 | Eur. Urol. | pmid:21211899 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Baudrand R et al. | Overexpression of hepatic 5α-reductase and 11β-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients. | 2011 | Metab. Clin. Exp. | pmid:21704348 |
| Mohler JL et al. | Potential prostate cancer drug target: bioactivation of androstanediol by conversion to dihydrotestosterone. | 2011 | Clin. Cancer Res. | pmid:21705451 |
| Sen S et al. | Restoration of IFNγR subunit assembly, IFNγ signaling and parasite clearance in Leishmania donovani infected macrophages: role of membrane cholesterol. | 2011 | PLoS Pathog. | pmid:21931549 |
| Griffin JE et al. | High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. | 2011 | PLoS Pathog. | pmid:21980284 |
| Le Lay S et al. | Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux. | 2011 | PLoS ONE | pmid:21858084 |
| Li L et al. | Selective induction of apoptosis in the hamster flank sebaceous gland organ by a topical liposome 5-alpha-reductase inhibitor: a treatment strategy for acne. | 2010 | J. Dermatol. | pmid:20175850 |
| Johnston JB et al. | Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses. | 2010 | J. Biol. Chem. | pmid:20843794 |
| Tibolla G et al. | Increased atherosclerosis and vascular inflammation in APP transgenic mice with apolipoprotein E deficiency. | 2010 | Atherosclerosis | pmid:19945109 |
| Wang X et al. | Establishment of a novel model for studying the effects of extracts of Chinese herb medicine on human type II 5alpha-reductase in vitro. | 2010 | Yakugaku Zasshi | pmid:20823678 |
| Martin LJ | Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis. | 2010 | IDrugs | pmid:20721828 |
| van Gorselen EO et al. | Artifactual measurement of low serum HDL-cholesterol due to paraproteinemia. | 2010 | Clin Res Cardiol | pmid:20593189 |
| Volontè F et al. | Production of recombinant cholesterol oxidase containing covalently bound FAD in Escherichia coli. | 2010 | BMC Biotechnol. | pmid:20409334 |
| Oh CY et al. | Korean urologist's view of practice patterns in diagnosis and management of benign prostatic hyperplasia: a nationwide survey. | 2010 | Yonsei Med. J. | pmid:20191018 |
| Gravas S and Oelke M | Current status of 5alpha-reductase inhibitors in the management of lower urinary tract symptoms and BPH. | 2010 | World J Urol | pmid:19956956 |
| Lin AS et al. | Structure and biological evaluation of novel cytotoxic sterol glycosides from the marine red alga Peyssonnelia sp. | 2010 | Bioorg. Med. Chem. | pmid:21036050 |
| Ouellet H et al. | Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one. | 2010 | Mol. Microbiol. | pmid:20545858 |
| Campino C et al. | 11β-Hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in the pathogenia of essential hypertension. | 2010 | Endocrine | pmid:19882252 |
| Driscoll MD et al. | Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen. | 2010 | J. Biol. Chem. | pmid:20889498 |
| Cohen P | Do 5-alpha reductase inhibitors influence the severity of brain injury in men after a stroke? | 2010 | Med. Hypotheses | pmid:20202761 |
| Hong SK et al. | Effect of the dual 5alpha-reductase inhibitor, dutasteride, on serum testosterone and body mass index in men with benign prostatic hyperplasia. | 2010 | BJU Int. | pmid:19793378 |
| Edrees MM et al. | Antimicrobial, antitumor and 5α-reductase inhibitor activities of some hydrazonoyl substituted pyrimidinones. | 2010 | Eur J Med Chem | pmid:20933305 |
| Ismail SI and Mazen IA | A study of gender outcome of Egyptian patients with 46,XY disorder of sex development. | 2010 | Sex Dev | pmid:20664246 |
| Chung DE and Kaplan SA | Current role for combination therapy in male LUTS. | 2010 | Arch. Esp. Urol. | pmid:20587837 |
| Brun EM et al. | Enzyme-linked immunosorbent assays for doping control of 5alpha-reductase inhibitors finasteride and dutasteride. | 2010 | Anal. Chim. Acta | pmid:20541645 |
| Trüeb RM | [Hormones and hair growth]. | 2010 | Hautarzt | pmid:20502852 |
| Helfand BT et al. | Consequences of switching 5alpha-reductase inhibitors on prostate specific antigen velocity. | 2010 | J. Urol. | pmid:20483154 |
| Rovini A et al. | Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells. | 2010 | Biochem. Pharmacol. | pmid:20417191 |
| Elterman DS et al. | Investigating contamination of phytotherapy products for benign prostatic hyperplasia with alpha-blockers and 5alpha-reductase inhibitors. | 2010 | J. Urol. | pmid:20303529 |
| Bühler P et al. | Comparison of gene expression in LNCaP prostate cancer cells after treatment with bicalutamide or 5-alpha-reductase inhibitors. | 2010 | Urol. Int. | pmid:20215827 |
| Shore N | NX-1207: a novel investigational drug for the treatment of benign prostatic hyperplasia. | 2010 | Expert Opin Investig Drugs | pmid:20050813 |
| Aloisi AM et al. | Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats. | 2010 | Mol Pain | pmid:20977699 |
| Kasashima S et al. | Androgen receptor and 5alpha-reductase immunohistochemical profiles in extramammary Paget disease. | 2010 | Br. J. Dermatol. | pmid:19995364 |
| Aggarwal S et al. | 3D-QSAR studies on unsaturated 4-azasteroids as human 5alpha-reductase inhibitors: a self organizing molecular field analysis approach. | 2010 | Eur J Med Chem | pmid:19906465 |
| Hollingsworth JM and Wei JT | Does the combination of an alpha1-adrenergic antagonist with a 5alpha-reductase inhibitor improve urinary symptoms more than either monotherapy? | 2010 | Curr Opin Urol | pmid:19881352 |
| Cho CH et al. | 5alpha-reductase inhibitory components as antiandrogens from herbal medicine. | 2010 | J Acupunct Meridian Stud | pmid:20633525 |
| Cohen RE and Wade J | Testosterone selectively affects aromatase and 5alpha-reductase activities in the green anole lizard brain. | 2010 | Gen. Comp. Endocrinol. | pmid:19917285 |
| Gupta S et al. | Inhibition of 5alpha-reductase enhances testosterone-induced expression of U19/Eaf2 tumor suppressor during the regrowth of LNCaP xenograft tumor in nude mice. | 2010 | Prostate | pmid:20564326 |
| Ooi LG and Liong MT | Cholesterol-lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings. | 2010 | Int J Mol Sci | pmid:20640165 |
| Verhovshek T et al. | Testosterone metabolites differentially maintain adult morphology in a sexually dimorphic neuromuscular system. | 2010 | Dev Neurobiol | pmid:20024940 |
| Dovbnya DV et al. | Microbial side-chain degradation of ergosterol and its 3-substituted derivatives: a new route for obtaining of deltanoids. | 2010 | Steroids | pmid:20385161 |
| Guardiola-Serrano F et al. | Palmitoylation of human FasL modulates its cell death-inducing function. | 2010 | Cell Death Dis | pmid:21368861 |
| Taplin ME et al. | Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer. | 2009 | Clin. Cancer Res. | pmid:19887483 |
| Capyk JK et al. | Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. | 2009 | J. Biol. Chem. | pmid:19846551 |
| Ditscheid B et al. | Faecal steroid excretion in humans is affected by calcium supplementation and shows gender-specific differences. | 2009 | Eur J Nutr | pmid:19009227 |
4-Cholesten-3-one
4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.
Cross Reference
Introduction
To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 4-Cholesten-3-one?
4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Biochem. J. (1)
- J. Biol. Chem. (1)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- Others (3)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with 4-Cholesten-3-one
Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 4-Cholesten-3-one?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Biol. Chem. (2)
- J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (1)
- J. Lipid Res. (1)
- Others (2)
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with 4-Cholesten-3-one?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 4-Cholesten-3-one?
There are no associated biomedical information in the current reference collection.