4-Cholesten-3-one

4-Cholesten-3-one is a lipid of Sterol Lipids (ST) class. 4-cholesten-3-one is associated with abnormalities such as Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana and Xanthoma. The involved functions are known as CYP27A1activity, 25-hydroxycholesterol 7alpha-hydroxylase activity, Biochemical Pathway, Anabolism and Oxidation. 4-cholesten-3-one often locates in Mitochondria, Liver, Body tissue, Hepatic, Mitochondria and Endothelium of artery. The associated genes with 4-Cholesten-3-one are P4HTM gene, tryptones and Regulon. The related lipids are Cholestenones, 7-hydroxy-4-cholesten-3-one, cholest-4-en-3-one, 25-hydroxycholesterol and 24-hydroxycholesterol.

Cross Reference

Introduction

To understand associated biological information of 4-Cholesten-3-one, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-Cholesten-3-one?

4-Cholesten-3-one is suspected in Dehydration, Xanthomatosis, Cerebrotendinous, Peripheral Neuropathy, L.mexicana, Xanthoma, Rare Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with 4-Cholesten-3-one

Lipid pathways are not clear in current pathway databases. We organized associated pathways with 4-Cholesten-3-one through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-Cholesten-3-one?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 4-Cholesten-3-one?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-Cholesten-3-one?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 4-Cholesten-3-one?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-Cholesten-3-one?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 4-Cholesten-3-one

Download all related citations
Per page 10 20 50 100 | Total 397
Authors Title Published Journal PubMed Link
Ghosh S et al. Cholesterol-oxidase-magnetic nanobioconjugates for the production of 4-cholesten-3-one and 4-cholesten-3, 7-dione. 2018 Bioresour. Technol. pmid:29413944
Donato LJ et al. Description of analytical method and clinical utility of measuring serum 7-alpha-hydroxy-4-cholesten-3-one (7aC4) by mass spectrometry. 2018 Clin. Biochem. pmid:29051033
Chen CL et al. Cholest-4-en-3-one attenuates TGF-β responsiveness by inducing TGF-β receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells. 2017 J. Recept. Signal Transduct. Res. pmid:27401208
Chen L et al. A new ent-kaurane diterpenoid from Ixora amplexicaulis. 2016 Nat. Prod. Res. pmid:25941744
Ma J et al. 4-cholesten-3-one suppresses lung adenocarcinoma metastasis by regulating translocation of HMGB1, HIF1α and Caveolin-1. 2016 Cell Death Dis pmid:27899819
Mouzaki M et al. Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease. 2016 PLoS ONE pmid:27203081
Chen M et al. The rate-determining steps of aldo-keto reductases (AKRs), a study on human steroid 5β-reductase (AKR1D1). 2015 Chem. Biol. Interact. pmid:25500266
Lin CW et al. Substrate uptake and subcellular compartmentation of anoxic cholesterol catabolism in Sterolibacterium denitrificans. 2015 J. Biol. Chem. pmid:25418128
Walters JR et al. The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid. 2015 Aliment. Pharmacol. Ther. pmid:25329562
Benesch MG et al. A DSC and FTIR spectroscopic study of the effects of the epimeric 4-cholesten-3-ols and 4-cholesten-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: comparison with their 5-cholesten analogues. 2014 Chem. Phys. Lipids pmid:24296232
Neuvonen M et al. Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. 2014 PLoS ONE pmid:25157633
Bouvaine S et al. A dietary test of putative deleterious sterols for the aphid Myzus persicae. 2014 PLoS ONE pmid:24465993
García-Fernández E et al. A highly conserved mycobacterial cholesterol catabolic pathway. 2013 Environ. Microbiol. pmid:23489718
Pan L et al. Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii. 2012 Phytochemistry pmid:22840389
Martel C et al. Inhibition of the Mitochondrial Permeability Transition for Cytoprotection: Direct versus Indirect Mechanisms. 2012 Biochem Res Int pmid:22675634
Biswas A et al. Influence of pioglitazone on experimental heart failure and hyperlipidemia in rats. 2012 Indian J Pharmacol pmid:22701242
Jusakul A et al. Liver fluke-induced hepatic oxysterols stimulate DNA damage and apoptosis in cultured human cholangiocytes. 2012 Mutat. Res. pmid:22044627
Cieślak J et al. Convenient and efficient approach to the permanent or reversible conjugation of RNA and DNA sequences with functional groups. 2012 Curr Protoc Nucleic Acid Chem pmid:22956458
Muto A et al. Detection of Δ4-3-oxo-steroid 5β-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids. 2012 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:22695323
Kumar M et al. Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. 2012 Exp Diabetes Res pmid:22611376