DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Simonen P et al. | Desmosterol accumulation in users of amiodarone. | 2018 | J. Intern. Med. | pmid:28861933 |
| Müller C et al. | New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. | 2017 | Eur J Med Chem | pmid:28964935 |
| Mouritsen OG et al. | Effects of seaweed sterols fucosterol and desmosterol on lipid membranes. | 2017 | Chem. Phys. Lipids | pmid:28365392 |
| Hamdan IJA et al. | Sterols in infant formulas: validation of a gas chromatographic method. | 2017 | Int J Food Sci Nutr | pmid:28276904 |
| Kazkayasi I et al. | Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats. | 2016 | Neurosci. Lett. | pmid:27639960 |
| Zhao Q et al. | A highly stereoselective synthesis of C-24 and C-25 oxysterols from desmosterol. | 2016 | Steroids | pmid:26968128 |
| Andrade I et al. | Cholesterol absorption and synthesis markers in Portuguese hypercholesterolemic adults: A cross-sectional study. | 2016 | Eur. J. Intern. Med. | pmid:26577223 |
| Yin L et al. | Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis. | 2016 | Toxicol In Vitro | pmid:26820058 |
| Villareal VA et al. | Hepatitis C Virus Selectively Alters the Intracellular Localization of Desmosterol. | 2016 | ACS Chem. Biol. | pmid:27128812 |
| Costello DA et al. | Desmosterol Increases Lipid Bilayer Fluidity during Hepatitis C Virus Infection. | 2016 | ACS Infect Dis | pmid:27933788 |