DESMOSTEROL is a lipid of Sterol Lipids (ST) class. Desmosterol is associated with abnormalities such as Cataract, Congenital Abnormality, Liver diseases, Erectile dysfunction and Multiple congenital anomalies. The involved functions are known as Bulla, Methylation, cholesterol biosynthetic process, Process and cholesterol efflux. Desmosterol often locates in Body tissue, Tissue membrane, Plasma membrane, Pore and Endoplasmic Reticulum. The associated genes with DESMOSTEROL are P4HTM gene, SHH gene, WDR48 gene, CFLAR gene and SLC33A1 gene. The related lipids are Sterols, androstanol, Steroids, Unilamellar Vesicles and 7-dehydrocholesterol. The related experimental models are Transgenic Model and Rodent Model.
To understand associated biological information of DESMOSTEROL, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DESMOSTEROL is suspected in Atherosclerosis, Congenital Abnormality, Liver diseases, Fatty Streak, Arterial, Senile Plaques, Coronary Arteriosclerosis and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with DESMOSTEROL
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Limb Deformities, Congenital | D017880 | 4 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with DESMOSTEROL through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Transgenic Model are used in the study 'Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.' (Wei D et al., 2010).
Rodent Model are used in the study 'Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.' (Goyal S et al., 2014).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Haldar S et al. | Differential effect of cholesterol and its biosynthetic precursors on membrane dipole potential. | 2012 | Biophys. J. | pmid:22500756 |
| Tansley G et al. | Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. | 2012 | Curr Gerontol Geriatr Res | pmid:22649448 |
| Meljon A et al. | Analysis of bioactive oxysterols in newborn mouse brain by LC/MS. | 2012 | J. Lipid Res. | pmid:22891291 |
| Bieghs V et al. | Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells. | 2012 | PLoS ONE | pmid:22470565 |
| Kasmas SH et al. | Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies. | 2012 | Braz. J. Med. Biol. Res. | pmid:22801416 |
| McDonald JG et al. | A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma. | 2012 | J. Lipid Res. | pmid:22517925 |
| Cacabelos R et al. | Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics. | 2012 | Int J Alzheimers Dis | pmid:22482072 |
| Khanavi M et al. | Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. | 2012 | Pharmacogn Mag | pmid:22438665 |
| Silbernagel G et al. | Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans. | 2012 | Exp Diabetes Res | pmid:22203835 |
| Matysik S et al. | Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors. | 2012 | Clin. Chem. | pmid:22997279 |