|MeSH term||MeSH ID||Detail|
|Carcinoma, Hepatocellular||D006528||140 associated lipids|
|Abetalipoproteinemia||D000012||7 associated lipids|
|Leukemia, Hairy Cell||D007943||5 associated lipids|
|Xanthomatosis||D014973||17 associated lipids|
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
|Disease||Cross reference||Weighted score||Related literature|
We collected disease MeSH terms mapped to the references associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
|Pathway name||Related literatures|
Associated locations are in red color. Not associated locations are in black.
|Function||Cross reference||Weighted score||Related literatures|
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
|Zhu J et al.||Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway.||2018||Chem. Biol. Interact.||pmid:29852127|
|Teng Y et al.||Hebecarposides A-K, antiproliferative lanostane-type triterpene glycosides from the leaves of Lyonia ovalifolia var. hebecarpa.||2018||Phytochemistry||pmid:29660562|
|Freitas HF et al.||Cloning, expression, purification and spectrophotometric analysis of lanosterol 14-alpha demethylase from Leishmania braziliensis (LbCYP51).||2018||Mol. Biol. Rep.||pmid:29363024|
|Lu DL et al.||Reproducibility of serum oxysterols and lanosterol among postmenopausal women: Results from EPIC-Heidelberg.||2018||Clin. Biochem.||pmid:29108727|
|Chen XQ et al.||Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against Î±-glucosidase.||2018||Phytochemistry||pmid:29490285|
|Vidal-Limon AM et al.||Molecular Dynamics and Virtual Screening Analysis of Lanosterol Derivatives from Ganoderma Medicinal Mushrooms (Agaricomycetes) as Selective Ligands of Human Androgen Receptor.||2017||Int J Med Mushrooms||pmid:29199581|
|Lin CH et al.||Eburicoic Acid, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects in Palmitate-Treated C2C12 Myotubes and in High-Fat Diet-Fed Mice.||2017||Int J Mol Sci||pmid:29099085|
|Kidane ME et al.||Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design.||2017||J. Lipid Res.||pmid:29042405|
|Yusakul G et al.||Bacterial Expression of a Single-Chain Variable Fragment (scFv) Antibody against Ganoderic Acid A: A Cost-Effective Approach for Quantitative Analysis Using the scFv-Based Enzyme-Linked Immunosorbent Assay.||2017||Biol. Pharm. Bull.||pmid:28966249|
|Katja DG et al.||Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae).||2017||J Asian Nat Prod Res||pmid:27329305|