| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Leukemia, Hairy Cell | D007943 | 5 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
Total
4
lanosterol
lanosterol is a lipid of Sterol Lipids (ST) class. Lanosterol is associated with abnormalities such as Infection, Atherosclerosis, Myocardial Infarction, Chagas Disease and Fatty Liver. The involved functions are known as Signal, Cytokinesis, physiological aspects, Stereochemistry and ergosterol biosynthetic process. Lanosterol often locates in Body tissue, Membrane, Plasma membrane, Tissue membrane and Cytoskeletal Filaments. The associated genes with lanosterol are Retinoic Acid Response Element, P4HTM gene, CYP51A1 gene, HM13 gene and SC4MOL gene. The related lipids are pneumocysterol, Sterols, lanosteryl acetate, ebericol and cycloartenol. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of lanosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with lanosterol?
lanosterol is suspected in Atherosclerosis, Chagas Disease, vaginalis, hypercholesterolemia, Obesity, Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with lanosterol
PubChem Associated disorders and diseases
What pathways are associated with lanosterol
Lipid pathways are not clear in current pathway databases. We organized associated pathways with lanosterol through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with lanosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with lanosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with lanosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with lanosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with lanosterol?
Knock-out
Knock-out are used in the study 'Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.' (Ohyama K et al., 2009), Knock-out are used in the study 'Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.' (Warrilow AG et al., 2010) and Knock-out are used in the study 'Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.' (D'Agostino J et al., 2012).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with lanosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhu J et al. | Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway. | 2018 | Chem. Biol. Interact. | pmid:29852127 |
| Teng Y et al. | Hebecarposides A-K, antiproliferative lanostane-type triterpene glycosides from the leaves of Lyonia ovalifolia var. hebecarpa. | 2018 | Phytochemistry | pmid:29660562 |
| Freitas HF et al. | Cloning, expression, purification and spectrophotometric analysis of lanosterol 14-alpha demethylase from Leishmania braziliensis (LbCYP51). | 2018 | Mol. Biol. Rep. | pmid:29363024 |
| Lu DL et al. | Reproducibility of serum oxysterols and lanosterol among postmenopausal women: Results from EPIC-Heidelberg. | 2018 | Clin. Biochem. | pmid:29108727 |
| Chen XQ et al. | Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase. | 2018 | Phytochemistry | pmid:29490285 |
| Dai J et al. | Elimination of quiescent slow-cycling cells via reducing quiescence depth by natural compounds purified from Ganoderma lucidum. | 2017 | Oncotarget | pmid:28099150 |
| Sidjui LS et al. | Bioactive Seco-Lanostane-Type Triterpenoids from the Roots of Leplaea mayombensis. | 2017 | J. Nat. Prod. | pmid:28945373 |
| Lv L et al. | Quantitation of lanosterol in the vitreous humor of rabbits after ocular administration of lanosterol/thermogel formulation by ultra high performance liquid chromatography-tandem mass spectrometry with the electrospray ionization mode. | 2017 | J Chromatogr A | pmid:28888677 |
| Vidal-Limon AM et al. | Molecular Dynamics and Virtual Screening Analysis of Lanosterol Derivatives from Ganoderma Medicinal Mushrooms (Agaricomycetes) as Selective Ligands of Human Androgen Receptor. | 2017 | Int J Med Mushrooms | pmid:29199581 |
| Park JW et al. | Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14α-demethylase. | 2017 | Biochem. J. | pmid:28830911 |
| Lin CH et al. | Eburicoic Acid, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects in Palmitate-Treated C2C12 Myotubes and in High-Fat Diet-Fed Mice. | 2017 | Int J Mol Sci | pmid:29099085 |
| Huang SZ et al. | Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum. | 2017 | Phytochemistry | pmid:28800421 |
| Kidane ME et al. | Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design. | 2017 | J. Lipid Res. | pmid:29042405 |
| Isaka M et al. | Antitubercular Activity of Mycelium-Associated Ganoderma Lanostanoids. | 2017 | J. Nat. Prod. | pmid:28504879 |
| Yusakul G et al. | Bacterial Expression of a Single-Chain Variable Fragment (scFv) Antibody against Ganoderic Acid A: A Cost-Effective Approach for Quantitative Analysis Using the scFv-Based Enzyme-Linked Immunosorbent Assay. | 2017 | Biol. Pharm. Bull. | pmid:28966249 |
| Cao FR et al. | Plasma and brain pharmacokinetics of ganoderic acid A in rats determined by a developed UFLC-MS/MS method. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:28346885 |
| Wang X et al. | Ganoderic acid A inhibits proliferation and invasion, and promotes apoptosis in human hepatocellular carcinoma cells. | 2017 | Mol Med Rep | pmid:28731159 |
| Wang J et al. | Eburicoic acid from Laetiporus sulphureus (Bull.:Fr.) Murrill attenuates inflammatory responses through inhibiting LPS-induced activation of PI3K/Akt/mTOR/NF-κB pathways in RAW264.7 cells. | 2017 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:28577049 |
| Zhang DH et al. | Overexpression of the homologous lanosterol synthase gene in ganoderic acid biosynthesis in Ganoderma lingzhi. | 2017 | Phytochemistry | pmid:27894599 |
| Zhang G et al. | Ethylene promotes mycelial growth and ganoderic acid biosynthesis in Ganoderma lucidum. | 2017 | Biotechnol. Lett. | pmid:27771819 |
| Katja DG et al. | Cytototoxic constituents from the bark of Chisocheton cumingianus (Meliaceae). | 2017 | J Asian Nat Prod Res | pmid:27329305 |
| Gao Y et al. | In Vitro and In Vivo Activity of Fomitopsis Pinicola (Sw. Ex Fr.) Karst Chloroform (Fpkc) Extract Against S180 Tumor Cells. | 2017 | Cell. Physiol. Biochem. | pmid:29241162 |
| Wang XL et al. | Efficient Accumulation and In Vitro Antitumor Activities of Triterpene Acids from Submerged Batch--Cultured Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes). | 2017 | Int J Med Mushrooms | pmid:28845771 |
| Araldi E et al. | Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages. | 2017 | Cell Rep | pmid:28658622 |
| Tallman KA et al. | Probes for protein adduction in cholesterol biosynthesis disorders: Alkynyl lanosterol as a viable sterol precursor. | 2017 | Redox Biol | pmid:28258022 |
| Kim JW et al. | Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. | 2016 | Int J Mol Sci | pmid:27801787 |
| Wang XL et al. | Improved Production and Antitumor Properties of Triterpene Acids from Submerged Culture of Ganoderma lingzhi. | 2016 | Molecules | pmid:27775633 |
| Venkatesh R et al. | Comment to: Effect of lanosterol on human nuclei. | 2016 | Indian J Ophthalmol | pmid:27488164 |
| Hargrove TY et al. | Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design. | 2016 | J. Lipid Res. | pmid:27313059 |
| Kuo YH et al. | Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor α Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice. | 2016 | Int J Mol Sci | pmid:27271603 |
| Warrilow AG et al. | The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme. | 2016 | Antimicrob. Agents Chemother. | pmid:27161631 |
| Stäubert C et al. | Increased lanosterol turnover: a metabolic burden for daunorubicin-resistant leukemia cells. | 2016 | Med. Oncol. | pmid:26698156 |
| Schrack S et al. | Oxysterols in cosmetics-Determination by planar solid phase extraction and gas chromatography-mass spectrometry. | 2016 | J Chromatogr A | pmid:28314390 |
| Suarez-Medellin J et al. | In Silico Analysis of Lanostanoids Characterized in Ganoderma Mushrooms (Agaricomycetes) as Potential Ligands of the Vitamin D Receptor. | 2016 | Int J Med Mushrooms | pmid:28008815 |
| Lai KH et al. | Cytotoxic Lanostanoids from Poria cocos. | 2016 | J. Nat. Prod. | pmid:27808511 |
| Hongthong S et al. | Cytotoxic lanostanes from fruits of Garcinia wallichii Choisy (Guttiferae). | 2016 | Bioorg. Med. Chem. Lett. | pmid:27793565 |
| Hu ZX et al. | Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea. | 2016 | J. Nat. Prod. | pmid:27704807 |
| Gill BS et al. | Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer. | 2016 | Mol. Biol. Rep. | pmid:27640015 |
| Sakamoto S et al. | Immunochromatographic strip assay for detection of bioactive Ganoderma triterpenoid, ganoderic acid A in Ganoderma lingzhi. | 2016 | Fitoterapia | pmid:27575328 |
| Kwon J et al. | Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis. | 2016 | J. Nat. Prod. | pmid:27266877 |
| Han J et al. | Officimalonic acids A-H, lanostane triterpenes from the fruiting bodies of Fomes officinalis. | 2016 | Phytochemistry | pmid:27216472 |
| Sakamoto S et al. | Detection of Ganoderic Acid A in Ganoderma lingzhi by an Indirect Competitive Enzyme-Linked Immunosorbent Assay. | 2016 | Planta Med. | pmid:27093250 |
| Li HJ et al. | Enhancement of ganoderic acid production by constitutively expressing Vitreoscilla hemoglobin gene in Ganoderma lucidum. | 2016 | J. Biotechnol. | pmid:27080449 |
| Amen YM et al. | Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells. | 2016 | J Nat Med | pmid:26899240 |
| Isaka M et al. | Antitubercular Lanostane Triterpenes from Cultures of the Basidiomycete Ganoderma sp. BCC 16642. | 2016 | J. Nat. Prod. | pmid:26716912 |
| Qiu J et al. | Neuroprotective and antioxidant lanostanoid triterpenes from the fruiting bodies of Ganoderma atrum. | 2016 | Fitoterapia | pmid:26709153 |
| Lee S et al. | Lanosterol influences cytoplasmic maturation of pig oocytes in vitro and improves preimplantation development of cloned embryos. | 2016 | Theriogenology | pmid:26494176 |
| OuYang Q et al. | Transcriptional profiling analysis of Penicillium digitatum, the causal agent of citrus green mold, unravels an inhibited ergosterol biosynthesis pathway in response to citral. | 2016 | BMC Genomics | pmid:27514516 |
| Novack GD | Eyes on New Product Development. | 2016 | J Ocul Pharmacol Ther | pmid:27058691 |
| AÄimoviÄ J et al. | Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis. | 2016 | Sci Rep | pmid:27334049 |
| Chen N et al. | Biosynthetic Mechanism of Lanosterol: Cyclization. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:26069216 |
| Das A et al. | A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway. | 2015 | Tumour Biol. | pmid:25864108 |
| Shanmugam PM et al. | Effect of lanosterol on human cataract nucleus. | 2015 | Indian J Ophthalmol | pmid:26862091 |
| Mendiara I et al. | Online solid-phase extraction-liquid chromatography-mass spectrometry to determine free sterols in human serum. | 2015 | Talanta | pmid:25476366 |
| Mosa RA et al. | In vivo antihyperglycemic activity of a lanosteryl triterpene from Protorhus longifolia. | 2015 | Molecules | pmid:26205060 |
| Sagatova AA et al. | Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase. | 2015 | Antimicrob. Agents Chemother. | pmid:26055382 |
| Price CL et al. | Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase. | 2015 | Appl. Environ. Microbiol. | pmid:25746994 |
| Zhang SS et al. | Three new lanostanoids from the mushroom Ganoderma tropicum. | 2015 | Molecules | pmid:25690289 |
| Dutra RC et al. | The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε. | 2015 | Neuroscience | pmid:26143011 |
| Zhao XR et al. | Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and α-Glucosidase. | 2015 | J. Nat. Prod. | pmid:26222905 |
| Wang J et al. | Protective Effect of Eburicoic Acid of the Chicken of the Woods Mushroom, Laetiporus sulphureus (Higher Basidiomycetes), Against Gastric Ulcers in Mice. | 2015 | Int J Med Mushrooms | pmid:26559696 |
| Quinlan RA | DRUG DISCOVERY. A new dawn for cataracts. | 2015 | Science | pmid:26542559 |
| Kuo YH et al. | Antidiabetic and Antihyperlipidemic Properties of a Triterpenoid Compound, Dehydroeburicoic Acid, from Antrodia camphorata in Vitro and in Streptozotocin-Induced Mice. | 2015 | J. Agric. Food Chem. | pmid:26503742 |
| Gundersen BB | Clearing cataracts without surgery. | 2015 | Lab Anim (NY) | pmid:26398599 |
| Hu ZX et al. | Kadcoccinones A-F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons from Kadsura coccinea. | 2015 | Org. Lett. | pmid:26348535 |
| Ruan W et al. | Distinct Responses of Cytotoxic Ganoderma lucidum Triterpenoids in Human Carcinoma Cells. | 2015 | Phytother Res | pmid:26292672 |
| Zhao L et al. | Lanosterol reverses protein aggregation in cataracts. | 2015 | Nature | pmid:26200341 |
| Hejtmancik JF | Ophthalmology: Cataracts dissolved. | 2015 | Nature | pmid:26200338 |
| Li G et al. | Endophytic Diaporthe sp. LG23 Produces a Potent Antibacterial Tetracyclic Triterpenoid. | 2015 | J. Nat. Prod. | pmid:26186257 |
| Feng W and Yang JS | A new drimane sesquiterpenoid and a new triterpene lactone from fungus of Fomes officinalis. | 2015 | J Asian Nat Prod Res | pmid:26123159 |
| Wang GW et al. | Lanostane-type triterpenoids from Abies faxoniana and their DNA topoisomerase inhibitory activities. | 2015 | Phytochemistry | pmid:25986863 |
| Kürten C et al. | Overexpression of functional human oxidosqualene cyclase in Escherichia coli. | 2015 | Protein Expr. Purif. | pmid:25962741 |
| Yin X et al. | Four lanostane-type triterpenes from the fruiting bodies of mushroom Laetiporus sulphureus var. miniatus. | 2015 | J Asian Nat Prod Res | pmid:25916960 |
| O'Keeffe R et al. | Synthesis of novel 24-amino-25,26,27-trinorlanost-8-enes: cytotoxic and apoptotic potential in U937 cells. | 2015 | Bioorg. Med. Chem. | pmid:25800433 |
| Liu JY et al. | Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China. | 2015 | Res. Microbiol. | pmid:25748216 |
| Leoni V and Caccia C | The impairment of cholesterol metabolism in Huntington disease. | 2015 | Biochim. Biophys. Acta | pmid:25596342 |
| Zhang SS et al. | Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes. | 2015 | Phytochemistry | pmid:25577284 |
| Jamila N et al. | Molecular docking studies and in vitro cholinesterase enzyme inhibitory activities of chemical constituents of Garcinia hombroniana. | 2015 | Nat. Prod. Res. | pmid:25219673 |
| Chen CL et al. | Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. | 2015 | PLoS ONE | pmid:26448474 |
| Ren A et al. | Transcript and metabolite alterations increase ganoderic acid content in Ganoderma lucidum using acetic acid as an inducer. | 2014 | Biotechnol. Lett. | pmid:25216642 |
| Chiba T et al. | Fomiroid A, a novel compound from the mushroom Fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe. | 2014 | PLoS ONE | pmid:25551765 |
| Machaba KE et al. | In vivo anti-hyperlipidemic activity of the triterpene from the stem bark of Protorhus longifolia (Benrh) Engl. | 2014 | Lipids Health Dis | pmid:25127687 |
| Zhao LW et al. | Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells. | 2014 | Asian Pac. J. Cancer Prev. | pmid:24815470 |
| Jennings GK et al. | Spin equilibrium and Oâ‚‚-binding kinetics of Mycobacterium tuberculosis CYP51 with mutations in the histidine-threonine dyad. | 2014 | J. Inorg. Biochem. | pmid:24793591 |
| Munhoz AC et al. | Chemical and pharmacological investigation of the stem bark of Synadenium grantii. | 2014 | Planta Med. | pmid:24687740 |
| Peng XR et al. | Hepatoprotective effects of triterpenoids from Ganoderma cochlear. | 2014 | J. Nat. Prod. | pmid:24559087 |
| Liu C et al. | Chemical constituents from Inonotus obliquus and their biological activities. | 2014 | J. Nat. Prod. | pmid:24359303 |
| Ying YM et al. | Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus. | 2014 | Phytochemistry | pmid:25446238 |
| Mosa RA et al. | In vitro antihyperlipidemic potential of triterpenes from stem bark of Protorhus longifolia. | 2014 | Planta Med. | pmid:25389058 |
| Ruan W et al. | Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth. | 2014 | Nat. Prod. Res. | pmid:25032738 |
| Gas-Pascual E et al. | Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana. | 2014 | PLoS ONE | pmid:25343375 |
| Marco-Jiménez F et al. | Effect of lanosterol on the in vitro maturation in semi-defined culture system of prepubertal ewe oocytes. | 2014 | Zygote | pmid:21838962 |
| Baila-Rueda L et al. | Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24406166 |
| Cheng S et al. | Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7. | 2013 | Int. J. Oncol. | pmid:23588713 |
| Keber R et al. | Male germ cell-specific knockout of cholesterogenic cytochrome P450 lanosterol 14α-demethylase (Cyp51). | 2013 | J. Lipid Res. | pmid:23509403 |
| Yajima Y et al. | Production of Ginkgo leaf-shaped basidiocarps of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), containing high levels of α- and β-D-glucan and ganoderic acid A. | 2013 | Int J Med Mushrooms | pmid:23557369 |
| Lin KW et al. | Xanthine oxidase inhibitory lanostanoids from Ganoderma tsugae. | 2013 | Fitoterapia | pmid:23769935 |
| Kolesnikova SA et al. | Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge. | 2013 | J. Nat. Prod. | pmid:23978047 |
| Patkar P et al. | C-24-methylation of 26-fluorocycloartenols by recombinant sterol C-24-methyltransferase from soybean: evidence for channel switching and its phylogenetic implications. | 2013 | Biochem. J. | pmid:23984880 |
| Zhang Y et al. | [Dynamic accumulation of three main triterpenic acids in submerged cultivation mycelium of Poria cocos]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23944068 |