MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
Niemann-Pick Diseases | D009542 | 25 associated lipids |
Atherosclerosis | D050197 | 85 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fraz S et al. | Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). | 2018 | Aquat. Toxicol. | pmid:29494825 |
Shen C et al. | Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway. | 2017 | EBioMedicine | pmid:28161398 |
Kim SM et al. | 25-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis. | 2017 | Oncotarget | pmid:28060747 |
Olivier E et al. | Lipid deregulation in UV irradiated skin cells: Role of 25-hydroxycholesterol in keratinocyte differentiation during photoaging. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27208628 |
Bah SY et al. | Immune oxysterols: Role in mycobacterial infection and inflammation. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27155346 |
Charman M et al. | Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1. | 2017 | Traffic | pmid:28471037 |
Schöls L et al. | Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. | 2017 | Brain | pmid:29126212 |
Serquiña AKP et al. | Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection. | 2017 | MBio | pmid:28698273 |
Pereiro P et al. | Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish. | 2017 | Antiviral Res. | pmid:28789986 |
Cagno V et al. | Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2017 | Redox Biol | pmid:28359048 |