25-Hydroxycholesterol

25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 25-Hydroxycholesterol?

25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Atherosclerosis D050197 85 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with 25-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 25-Hydroxycholesterol?

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What functions are associated with 25-Hydroxycholesterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 25-Hydroxycholesterol?

Knock-out

Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 25-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
pmid:
Corman A et al. Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway. 2012 ACS Med Chem Lett pmid:24900386
Huijmans JG et al. Effects of some hydroxylated sterols on the steroid production in isolated rat adrenal glomerulosa and fasciculata/reticularis cells in the presence of potassium, angiotensin II or ACTH. 1984 Acta Endocrinol. pmid:6322498
Huijmans JG et al. Conversion of 22S-hydroxy-cholesterol and its effects on the metabolism of other sterols in rat adrenal cells and bovine adrenal mitochondria. 1982 Acta Endocrinol. pmid:6289587
Catarino S et al. Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells. 2012 Acta Ophthalmol pmid:22313893
Miszkiel G and Kotwica J Mechanism of action of noradrenaline on secretion of progesterone and oxytocin by the bovine corpus luteum in vitro. 2001 Acta Vet. Hung. pmid:11402689
Yoshida T et al. Origin of oxysterols in hepatic bile of patients with biliary infection. 2003 Am. J. Gastroenterol. pmid:14572579
Guyton JR et al. Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region. 1990 Am. J. Pathol. pmid:2201200
Ng LL and Davies JE HMG CoA reductase inhibitors affect Na(+)-H+ antiport activity in human lymphoblasts. 1991 Am. J. Physiol. pmid:1659206
Ma Y et al. 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway. 2008 Am. J. Physiol. Endocrinol. Metab. pmid:18854425