| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Total
4
25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 25-Hydroxycholesterol?
25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol
PubChem Associated disorders and diseases
What pathways are associated with 25-Hydroxycholesterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 25-Hydroxycholesterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 25-Hydroxycholesterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 25-Hydroxycholesterol?
Knock-out
Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 25-Hydroxycholesterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fraz S et al. | Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). | 2018 | Aquat. Toxicol. | pmid:29494825 |
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| Shen C et al. | Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway. | 2017 | EBioMedicine | pmid:28161398 |
| Kim SM et al. | 25-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis. | 2017 | Oncotarget | pmid:28060747 |
| Olivier E et al. | Lipid deregulation in UV irradiated skin cells: Role of 25-hydroxycholesterol in keratinocyte differentiation during photoaging. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27208628 |
| Bah SY et al. | Immune oxysterols: Role in mycobacterial infection and inflammation. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27155346 |
| Song Z et al. | Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection. | 2017 | Vet. Microbiol. | pmid:29103685 |
| Gomes B et al. | Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol. | 2017 | Molecules | pmid:29088094 |
| Wang Z et al. | Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury. | 2017 | Arch. Toxicol. | pmid:27052460 |
| Charman M et al. | Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1. | 2017 | Traffic | pmid:28471037 |
| Schöls L et al. | Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. | 2017 | Brain | pmid:29126212 |
| Dang EV et al. | Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. | 2017 | Cell | pmid:29033131 |
| Tricarico PM et al. | 25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway. | 2017 | Int. J. Biochem. Cell Biol. | pmid:28918367 |
| Li Z et al. | Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. | 2017 | Circulation | pmid:28794002 |
| Wang J et al. | Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication. | 2017 | J. Gen. Virol. | pmid:28631596 |
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| Gregus M et al. | Non-aqueous capillary electrophoretic separation of cholesterol and 25-hydroxycholesterol after derivatization with Girard P reagent. | 2017 | Chem. Phys. Lipids | pmid:28583433 |
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| Singh V et al. | Purification and identification of 25-hydroxycholesterol in a reptile: Seasonal variation and hormonal regulation. | 2017 | Gen. Comp. Endocrinol. | pmid:28126346 |
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| Rugor A et al. | Regioselective hydroxylation of cholecalciferol, cholesterol and other sterol derivatives by steroid C25 dehydrogenase. | 2017 | Appl. Microbiol. Biotechnol. | pmid:27726023 |
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| Cagno V et al. | Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2017 | Redox Biol | pmid:28359048 |
| Li J et al. | Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells. | 2016 | Oncotarget | pmid:27447558 |
| Shrivastava-Ranjan P et al. | 25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation. | 2016 | MBio | pmid:27999160 |
| Ou ZJ et al. | 25-Hydroxycholesterol impairs endothelial function and vasodilation by uncoupling and inhibiting endothelial nitric oxide synthase. | 2016 | Am. J. Physiol. Endocrinol. Metab. | pmid:27600825 |
| Li J et al. | Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol. | 2016 | J. Lipid Res. | pmid:27530118 |
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| Tuong ZK et al. | RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages. | 2016 | PLoS ONE | pmid:26812621 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
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| Iaea DB et al. | A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. | 2015 | J. Lipid Res. | pmid:26497473 |
| Kuder CH et al. | 3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines. | 2015 | Lipids | pmid:26494560 |
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| Singaravelu R et al. | Armand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunity. | 2015 | Can. J. Microbiol. | pmid:26182401 |
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| Lu H et al. | Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-γ in primary macrophages requires endogenous 25-hydroxycholesterol synthesis. | 2015 | Steroids | pmid:25759117 |
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| Ando H et al. | Transcriptional suppression of CTP:phosphoethanolamine cytidylyltransferase by 25-hydroxycholesterol is mediated by nuclear factor-Y and Yin Yang 1. | 2015 | Biochem. J. | pmid:26310456 |
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| Kentala H et al. | Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP-VAPA complexes and their impacts on organelle structure. | 2015 | Steroids | pmid:25681634 |
| Morita M et al. | Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells. | 2015 | J. Biochem. | pmid:25998247 |
| Rosales C et al. | CD1d serves as a surface receptor for oxidized cholesterol induction of peroxisome proliferator-activated receptor-γ. | 2015 | Atherosclerosis | pmid:25618030 |
| Zhao Q et al. | N-Hydroxyphthalimide catalyzed allylic oxidation of steroids with t-butyl hydroperoxide. | 2015 | Steroids | pmid:25527284 |
| Virginio VW et al. | Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. | 2015 | Free Radic. Res. | pmid:25465091 |
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| Matsuda H et al. | Regulation of rat hepatic α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase, a key enzyme in the tryptophan- NAD pathway, by dietary cholesterol and sterol regulatory element-binding protein-2. | 2014 | Eur J Nutr | pmid:25289390 |
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| Zhong W et al. | OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. | 2014 | Exp. Cell Res. | pmid:24424245 |
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| Fu H et al. | Interleukin-1 potently contributes to 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions. | 2014 | Atherosclerosis | pmid:25463072 |
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| Tuong ZK et al. | Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice. | 2013 | Endocrinology | pmid:23239817 |
| Liu SY et al. | Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. | 2013 | Immunity | pmid:23273844 |
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| Shibata N et al. | 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. | 2013 | J. Biol. Chem. | pmid:24189069 |
| Chalubinski M et al. | The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers. | 2013 | Inflamm. Res. | pmid:24077843 |
| Elsabrouty R et al. | Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells. | 2013 | Mol. Biol. Cell | pmid:24025715 |
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| Blanc M et al. | The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. | 2013 | Immunity | pmid:23273843 |
| Dasari B et al. | Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. | 2013 | Curr. Eye Res. | pmid:23841471 |
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