25-Hydroxycholesterol

25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 25-Hydroxycholesterol?

25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Atherosclerosis D050197 85 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with 25-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 25-Hydroxycholesterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 25-Hydroxycholesterol?

Knock-out

Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 25-Hydroxycholesterol

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Authors Title Published Journal PubMed Link
Fraz S et al. Gemfibrozil and carbamazepine decrease steroid production in zebrafish testes (Danio rerio). 2018 Aquat. Toxicol. pmid:29494825
Sun MY et al. 24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation. 2017 PLoS ONE pmid:28346482
Shen C et al. Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway. 2017 EBioMedicine pmid:28161398
Kim SM et al. 25-Hydroxycholesterol is involved in the pathogenesis of amyotrophic lateral sclerosis. 2017 Oncotarget pmid:28060747
Olivier E et al. Lipid deregulation in UV irradiated skin cells: Role of 25-hydroxycholesterol in keratinocyte differentiation during photoaging. 2017 J. Steroid Biochem. Mol. Biol. pmid:27208628
Bah SY et al. Immune oxysterols: Role in mycobacterial infection and inflammation. 2017 J. Steroid Biochem. Mol. Biol. pmid:27155346
Song Z et al. Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection. 2017 Vet. Microbiol. pmid:29103685
Wang Z et al. Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury. 2017 Arch. Toxicol. pmid:27052460
Charman M et al. Oxysterol-binding protein recruitment and activity at the endoplasmic reticulum-Golgi interface are independent of Sac1. 2017 Traffic pmid:28471037
Schöls L et al. Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. 2017 Brain pmid:29126212
Dang EV et al. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. 2017 Cell pmid:29033131
Tricarico PM et al. 25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway. 2017 Int. J. Biochem. Cell Biol. pmid:28918367
Li Z et al. Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. 2017 Circulation pmid:28794002
Wang J et al. Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication. 2017 J. Gen. Virol. pmid:28631596
Olivier E et al. 25-Hydroxycholesterol induces both P2X7-dependent pyroptosis and caspase-dependent apoptosis in human skin model: New insights into degenerative pathways. 2017 Chem. Phys. Lipids pmid:28599978
Gregus M et al. Non-aqueous capillary electrophoretic separation of cholesterol and 25-hydroxycholesterol after derivatization with Girard P reagent. 2017 Chem. Phys. Lipids pmid:28583433
Li C et al. 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. 2017 Immunity pmid:28314593
Serquiña AKP et al. Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection. 2017 MBio pmid:28698273
Pereiro P et al. Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish. 2017 Antiviral Res. pmid:28789986
Cagno V et al. Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. 2017 Redox Biol pmid:28359048