25-Hydroxycholesterol

25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of 25-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 25-Hydroxycholesterol?

25-Hydroxycholesterol is suspected in Atherosclerosis, Keratoconjunctivitis Sicca, Hypercholesterolemia, Fatty Streak, Arterial, Hypochondroplasia (disorder), Infection and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 25-Hydroxycholesterol

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Atherosclerosis D050197 85 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with 25-Hydroxycholesterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 25-Hydroxycholesterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 25-Hydroxycholesterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 25-Hydroxycholesterol?

Knock-out

Knock-out are used in the study 'Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.' (Schüle R et al., 2010) and Knock-out are used in the study 'SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.' (Porstmann T et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with 25-Hydroxycholesterol

Download all related citations
Per page 10 20 50 100 | Total 873
Authors Title Published Journal PubMed Link
Li J et al. Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells. 2016 Oncotarget pmid:27447558
Pataj Z et al. Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. 2016 J Chromatogr A pmid:26607314
Barnaba C et al. Cholesterol photo-oxidation: A chemical reaction network for kinetic modeling. 2016 Steroids pmid:27756542
Wen G et al. Sterol regulatory element-binding proteins are transcriptional regulators of the thyroglobulin gene in thyroid cells. 2016 Biochim. Biophys. Acta pmid:27321819
Alba G et al. 7-Keto-cholesterol and 25-hydroxy-1 cholesterol rapidly enhance ROS production in human neutrophils. 2016 Eur J Nutr pmid:26715521
Goto A et al. Oxysterol-binding Protein Activation at Endoplasmic Reticulum-Golgi Contact Sites Reorganizes Phosphatidylinositol 4-Phosphate Pools. 2016 J. Biol. Chem. pmid:26601944
Lee DH et al. Apocynin attenuates cholesterol oxidation product-induced programmed cell death by suppressing NF-κB-mediated cell death process in differentiated PC12 cells. 2015 Neurochem. Int. pmid:26122972
Chen JH and Peng DQ Is 25-hydroxycholesterol the interplay of statins and inflammation? 2015 Int. J. Cardiol. pmid:25726901
Kentala H et al. Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP-VAPA complexes and their impacts on organelle structure. 2015 Steroids pmid:25681634
Morita M et al. Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells. 2015 J. Biochem. pmid:25998247