Cerebrosterol

Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cerebrosterol?

Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cerebrosterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Nerve Degeneration D009410 53 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Cerebrosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cerebrosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cerebrosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cerebrosterol?

Related references are published most in these journals:

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What genes are associated with Cerebrosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cerebrosterol?

Mouse Model

Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Cerebrosterol

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Authors Title Published Journal PubMed Link
Nakazawa T et al. Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis. 2017 J. Steroid Biochem. Mol. Biol. pmid:26953980
Sun MY et al. 24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation. 2017 PLoS ONE pmid:28346482
Gambert S et al. Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol. 2017 Chem. Phys. Lipids pmid:28576383
Kasimov MR et al. 24S-Hydroxycholesterol enhances synaptic vesicle cycling in the mouse neuromuscular junction: Implication of glutamate NMDA receptors and nitric oxide. 2017 Neuropharmacology pmid:28153530
Cardenia V et al. Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. 2017 J. Steroid Biochem. Mol. Biol. pmid:27084531
Bezine M et al. Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. 2017 Chem. Phys. Lipids pmid:28322741
Liu Q et al. Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. 2016 Lipids Health Dis pmid:27724967
Sun MY et al. Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices. 2016 J. Neurophysiol. pmid:26745248
Wang HL et al. Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. 2016 J. Alzheimers Dis. pmid:26836015
La Marca V et al. Lecithin-cholesterol acyltransferase in brain: Does oxidative stress influence the 24-hydroxycholesterol esterification? 2016 Neurosci. Res. pmid:26454063