Cerebrosterol

Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cerebrosterol?

Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cerebrosterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Nerve Degeneration D009410 53 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Cerebrosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cerebrosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cerebrosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cerebrosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Cerebrosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cerebrosterol?

Mouse Model

Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Cerebrosterol

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Authors Title Published Journal PubMed Link
pmid:
Lütjohann D Cholesterol metabolism in the brain: importance of 24S-hydroxylation. 2006 Acta Neurol. Scand., Suppl.c pmid:16866909
Björkhem I et al. Oxysterols and Alzheimer's disease. 2006 Acta Neurol. Scand., Suppl.c pmid:16866910
Fourgeux C et al. Steady-state levels of retinal 24S-hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat. 2012 Acta Ophthalmol pmid:22998629
Lütjohann D et al. Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol. 2001 Acta Paediatr. pmid:11440099
Gamba P et al. Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. 2011 Aging Cell pmid:21272192
Gamba P et al. Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. 2014 Aging Cell pmid:24612036
Serrano-Pozo A et al. Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers. 2010 Jul-Sep Alzheimer Dis Assoc Disord pmid:20473136
DeBarber AE et al. Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol. 2008 Anal. Biochem. pmid:18555788
Raina A and Kaul D LXR-α genomics programmes neuronal death observed in Alzheimer's disease. 2010 Apoptosis pmid:20927647