Cerebrosterol

Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cerebrosterol?

Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cerebrosterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Nerve Degeneration D009410 53 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Cerebrosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cerebrosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cerebrosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cerebrosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Cerebrosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cerebrosterol?

Mouse Model

Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Cerebrosterol

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Authors Title Published Journal PubMed Link
pmid:
Lütjohann D et al. Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients. 2000 J. Lipid Res. pmid:10681402
Li-Hawkins J et al. Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. 2000 J. Biol. Chem. pmid:10748047
Bretillon L et al. Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface. 2000 J. Lipid Res. pmid:10787445
Papassotiropoulos A et al. Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease. 2000 Neuroreport pmid:10884051
Meaney S et al. Formation of oxysterols from different pools of cholesterol as studied by stable isotope technique: cerebral origin of most circulating 24S-hydroxycholesterol in rats, but not in mice. 2000 Biochim. Biophys. Acta pmid:10903480
Li D and Spencer TA Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. 2000 Steroids pmid:10978732
Norlin M et al. 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A). 2000 J. Lipid Res. pmid:11013305
Bretillon L et al. Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases. 2000 Neurosci. Lett. pmid:11027840
Russell DW Oxysterol biosynthetic enzymes. 2000 Biochim. Biophys. Acta pmid:11111082