Cerebrosterol

Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cerebrosterol?

Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cerebrosterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Nerve Degeneration D009410 53 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Cerebrosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cerebrosterol?

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What functions are associated with Cerebrosterol?


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What lipids are associated with Cerebrosterol?

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What genes are associated with Cerebrosterol?

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What common seen animal models are associated with Cerebrosterol?

Mouse Model

Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Cerebrosterol

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Authors Title Published Journal PubMed Link
Nakazawa T et al. Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis. 2017 J. Steroid Biochem. Mol. Biol. pmid:26953980
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Gambert S et al. Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol. 2017 Chem. Phys. Lipids pmid:28576383
Kasimov MR et al. 24S-Hydroxycholesterol enhances synaptic vesicle cycling in the mouse neuromuscular junction: Implication of glutamate NMDA receptors and nitric oxide. 2017 Neuropharmacology pmid:28153530
Cardenia V et al. Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. 2017 J. Steroid Biochem. Mol. Biol. pmid:27084531
Bezine M et al. Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. 2017 Chem. Phys. Lipids pmid:28322741
Liu Q et al. Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. 2016 Lipids Health Dis pmid:27724967
Sun MY et al. Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices. 2016 J. Neurophysiol. pmid:26745248
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Wang HL et al. Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. 2016 J. Alzheimers Dis. pmid:26836015
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Maarup TJ et al. Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann-Pick C1. 2015 Sep-Oct Mol. Genet. Metab. pmid:26189084
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Nury T et al. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). 2015 Steroids pmid:25683890
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Zhang J and Liu Q Cholesterol metabolism and homeostasis in the brain. 2015 Protein Cell pmid:25682154
Leoni V and Caccia C The impairment of cholesterol metabolism in Huntington disease. 2015 Biochim. Biophys. Acta pmid:25596342
Virginio VW et al. Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. 2015 Free Radic. Res. pmid:25465091
Burlot MA et al. Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology. 2015 Hum. Mol. Genet. pmid:26358780
Novakova L et al. Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. 2015 J. Neurol. Sci. pmid:26342940
Sugimoto H et al. Method development for the determination of 24S-hydroxycholesterol in human plasma without derivatization by high-performance liquid chromatography with tandem mass spectrometry in atmospheric pressure chemical ionization mode. 2015 J Sep Sci pmid:26249017
Vo DK et al. 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8. 2015 Steroids pmid:25697054
Pinçon A et al. Increased susceptibility of dyslipidemic LSR+/- mice to amyloid stress is associated with changes in cortical cholesterol levels. 2015 J. Alzheimers Dis. pmid:25690661
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Wood WG et al. Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis. 2014 J. Neurochem. pmid:24329875
Linsenbardt AJ et al. Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. 2014 Neuropharmacology pmid:24878244
Leoni V and Caccia C Study of cholesterol metabolism in Huntington's disease. 2014 Biochem. Biophys. Res. Commun. pmid:24525128
Khenjanta C et al. Association of CYP39A1, RUNX2 and oxidized alpha-1 antitrypsin expression in relation to cholangiocarcinoma progression. 2014 Asian Pac. J. Cancer Prev. pmid:25556446
Bandaru VV and Haughey NJ Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. 2014 BMC Neurosci pmid:25539717
Stiles AR et al. Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25201972
Gamba P et al. Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. 2014 Aging Cell pmid:24612036
Fourgeux C et al. In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina. 2014 Biochem. Biophys. Res. Commun. pmid:24491555
Meljon A et al. Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse. 2014 Biochem. Biophys. Res. Commun. pmid:24491562
Baila-Rueda L et al. Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. 2014 Biochem. Biophys. Res. Commun. pmid:24406166
La Marca V et al. The enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits the toxic effect of this oxysterol on SH-SY5Y cells. 2014 J. Neurochem. pmid:24620755
Yamanaka K et al. Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1. 2014 Cell Death Dis pmid:24407243
Gabbi C et al. Action mechanisms of Liver X Receptors. 2014 Biochem. Biophys. Res. Commun. pmid:24300092
Noguchi N et al. Diverse functions of 24(S)-hydroxycholesterol in the brain. 2014 Biochem. Biophys. Res. Commun. pmid:24530911
Paul SM et al. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. 2013 J. Neurosci. pmid:24174662
Saint-Pol J et al. Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. 2013 Brain Res. pmid:23603412
Ali Z et al. On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice. 2013 J. Lipid Res. pmid:23284090
Hughes TM et al. Brain cholesterol metabolism, oxysterols, and dementia. 2013 J. Alzheimers Dis. pmid:23076077
Leoni V and Caccia C Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. 2013 Biochem. Pharmacol. pmid:23541982
Freemantle E et al. Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. 2013 Int. J. Neuropsychopharmacol. pmid:23369504
Okabe A et al. Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death. 2013 Redox Biol pmid:24371802
Acimovic J et al. Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. 2013 PLoS ONE pmid:23844150
Matsuda A et al. 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1. 2013 J. Neurochem. pmid:23600914
Urano Y et al. Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking. 2013 FASEB J. pmid:23839932
Leoni V et al. Diagnostic power of 24S-hydroxycholesterol in cerebrospinal fluid: candidate marker of brain health. 2013 J. Alzheimers Dis. pmid:23666171
Leoni V and Caccia C 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases. 2013 Biochimie pmid:23041502
Leoni V et al. Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression. 2013 Neurobiol. Dis. pmid:23557875
Watanabe K et al. Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator. 2013 Biochem. Pharmacol. pmid:23732298
Björkhem I et al. Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. 2013 Neurosci. Lett. pmid:24035896
Fourgeux C et al. Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration. 2012 Invest. Ophthalmol. Vis. Sci. pmid:22977134
Sodero AO et al. Cholesterol loss during glutamate-mediated excitotoxicity. 2012 EMBO J. pmid:22343944
Popp J et al. Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. 2012 J. Neurochem. pmid:22845771
Fourgeux C et al. Steady-state levels of retinal 24S-hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat. 2012 Acta Ophthalmol pmid:22998629
Mateos L et al. side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. 2012 Neurodegener Dis pmid:22236548
Krištofiková Z et al. Interactions of amyloid β peptide 1-40 and cerebrosterol. 2012 Neurochem. Res. pmid:22089933
Hughes TM et al. Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. 2012 J. Alzheimers Dis. pmid:22377780
Emanuelsson I and Norlin M Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells. 2012 Neurosci. Lett. pmid:22884615
Saint-Pol J et al. Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-β peptide accumulation. 2012 J. Alzheimers Dis. pmid:22433669
Gamba P et al. Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. 2011 Aging Cell pmid:21272192
Zuliani G et al. Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study. 2011 BMC Neurol pmid:21970714
Jeitner TM et al. Oxysterol derivatives of cholesterol in neurodegenerative disorders. 2011 Curr. Med. Chem. pmid:21428891
Vanmierlo T et al. Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. 2011 Plant Foods Hum Nutr pmid:21431910
Mateos L et al. Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism. 2011 J. Biol. Chem. pmid:21628469
Seet RC et al. Oxidative damage in ischemic stroke revealed using multiple biomarkers. 2011 Stroke pmid:21700941
Fourgeux C et al. 24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma. 2011 Chem. Phys. Lipids pmid:21531213
Shafaati M et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. 2011 J. Intern. Med. pmid:21486371
Dujmovic I Cerebrospinal fluid and blood biomarkers of neuroaxonal damage in multiple sclerosis. 2011 Mult Scler Int pmid:22096642
Yamanaka K et al. 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. 2011 J. Biol. Chem. pmid:21613228
Seet RC et al. Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? 2011 Free Radic. Biol. Med. pmid:21420490
Mast N et al. Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. 2011 Invest. Ophthalmol. Vis. Sci. pmid:20881306
Liao WL et al. Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain. 2011 J. Proteome Res. pmid:21049985
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Cartagena CM et al. 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury. 2010 Brain Res. pmid:20053345
Ullrich C et al. Effects of cholesterol and its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices. 2010 Pharmacology pmid:20571288
Jenner AM et al. The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. 2010 Neuroscience pmid:20416362
Raina A and Kaul D LXR-α genomics programmes neuronal death observed in Alzheimer's disease. 2010 Apoptosis pmid:20927647
Hudry E et al. Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. 2010 Mol. Ther. pmid:19654569
Wang Y et al. A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). 2010 Biochim. Biophys. Acta pmid:20211758
Shafaati M et al. The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo. 2010 J. Lipid Res. pmid:19474457
Zhao S et al. Polar metabolite of cholesterol induces rat cognitive dysfunctions. 2009 Neuroscience pmid:19699274
Kölsch H et al. CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism. 2009 Eur. Psychiatry pmid:19286353
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Liao WL et al. Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry. 2009 Biochemistry pmid:19317426
Prasanthi JR et al. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. 2009 Mol Neurodegener pmid:19126211
Fourgeux C et al. Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels. 2009 Invest. Ophthalmol. Vis. Sci. pmid:19553612
Cook IT et al. 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation. 2009 Drug Metab. Dispos. pmid:19589875
Koschack J et al. Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. 2009 Neurobiol. Aging pmid:18061309
Solomon A et al. Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. 2009 Neurosci. Lett. pmid:19560513
Honda A et al. Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. 2009 J. Lipid Res. pmid:18815436
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Weiner MF et al. Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. 2008 Brain Inj pmid:18568715
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Bang HJ et al. A comparison of the potential unfavorable effects of oxycholesterol and oxyphytosterol in mice: different effects, on cerebral 24S-hydroxychoelsterol and serum triacylglycerols levels. 2008 Biosci. Biotechnol. Biochem. pmid:19060413
Kristofiková Z et al. Complex of amyloid beta peptides with 24-hydroxycholesterol and its effect on hemicholinium-3 sensitive carriers. 2008 Neurochem. Res. pmid:17717740
Leoni V et al. Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease. 2008 Brain pmid:18772220