| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
Total
4
Cerebrosterol
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
Cross Reference
Introduction
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Cerebrosterol?
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Cerebrosterol
PubChem Associated disorders and diseases
What pathways are associated with Cerebrosterol
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Cerebrosterol?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Cerebrosterol?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Cerebrosterol?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Cerebrosterol?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Cerebrosterol?
Mouse Model
Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Cerebrosterol
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nakazawa T et al. | Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26953980 |
| Sun MY et al. | 24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation. | 2017 | PLoS ONE | pmid:28346482 |
| Gambert S et al. | Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol. | 2017 | Chem. Phys. Lipids | pmid:28576383 |
| Kasimov MR et al. | 24S-Hydroxycholesterol enhances synaptic vesicle cycling in the mouse neuromuscular junction: Implication of glutamate NMDA receptors and nitric oxide. | 2017 | Neuropharmacology | pmid:28153530 |
| Cardenia V et al. | Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27084531 |
| Bezine M et al. | Evidence of K homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes. | 2017 | Chem. Phys. Lipids | pmid:28322741 |
| Liu Q et al. | Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. | 2016 | Lipids Health Dis | pmid:27724967 |
| Sun MY et al. | Endogenous 24S-hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices. | 2016 | J. Neurophysiol. | pmid:26745248 |
| Soncini M et al. | 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27671648 |
| Wang HL et al. | Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. | 2016 | J. Alzheimers Dis. | pmid:26836015 |
| La Marca V et al. | Lecithin-cholesterol acyltransferase in brain: Does oxidative stress influence the 24-hydroxycholesterol esterification? | 2016 | Neurosci. Res. | pmid:26454063 |
| Maarup TJ et al. | Intrathecal 2-hydroxypropyl-beta-cyclodextrin in a single patient with Niemann-Pick C1. | 2015 Sep-Oct | Mol. Genet. Metab. | pmid:26189084 |
| Zarrouk A et al. | Accumulation of 24S-hydroxycholesterol in neuronal SK-N-BE cells treated with hexacosanoic acid (C26:0): argument in favor of 24S-hydroxycholesterol as a potential biomarker of neurolipotoxicity. | 2015 | Rev. Neurol. (Paris) | pmid:25577946 |
| Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
| Ghosh S et al. | Chandipura virus perturbs cholesterol homeostasis leading to neuronal apoptosis. | 2015 | J. Neurochem. | pmid:26118540 |
| Zhang J and Liu Q | Cholesterol metabolism and homeostasis in the brain. | 2015 | Protein Cell | pmid:25682154 |
| Leoni V and Caccia C | The impairment of cholesterol metabolism in Huntington disease. | 2015 | Biochim. Biophys. Acta | pmid:25596342 |
| Virginio VW et al. | Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. | 2015 | Free Radic. Res. | pmid:25465091 |
| Burlot MA et al. | Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology. | 2015 | Hum. Mol. Genet. | pmid:26358780 |
| Novakova L et al. | Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. | 2015 | J. Neurol. Sci. | pmid:26342940 |
| Sugimoto H et al. | Method development for the determination of 24S-hydroxycholesterol in human plasma without derivatization by high-performance liquid chromatography with tandem mass spectrometry in atmospheric pressure chemical ionization mode. | 2015 | J Sep Sci | pmid:26249017 |
| Vo DK et al. | 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8. | 2015 | Steroids | pmid:25697054 |
| Pinçon A et al. | Increased susceptibility of dyslipidemic LSR+/- mice to amyloid stress is associated with changes in cortical cholesterol levels. | 2015 | J. Alzheimers Dis. | pmid:25690661 |
| van de Kraats C et al. | Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis. | 2014 | Mult. Scler. | pmid:23959711 |
| Testa G et al. | Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. | 2014 | PLoS ONE | pmid:24802026 |
| Wood WG et al. | Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis. | 2014 | J. Neurochem. | pmid:24329875 |
| Linsenbardt AJ et al. | Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. | 2014 | Neuropharmacology | pmid:24878244 |
| Leoni V and Caccia C | Study of cholesterol metabolism in Huntington's disease. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24525128 |
| Khenjanta C et al. | Association of CYP39A1, RUNX2 and oxidized alpha-1 antitrypsin expression in relation to cholangiocarcinoma progression. | 2014 | Asian Pac. J. Cancer Prev. | pmid:25556446 |
| Bandaru VV and Haughey NJ | Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. | 2014 | BMC Neurosci | pmid:25539717 |
| Stiles AR et al. | Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25201972 |
| Gamba P et al. | Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. | 2014 | Aging Cell | pmid:24612036 |
| Fourgeux C et al. | In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24491555 |
| Meljon A et al. | Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24491562 |
| Baila-Rueda L et al. | Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24406166 |
| La Marca V et al. | The enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits the toxic effect of this oxysterol on SH-SY5Y cells. | 2014 | J. Neurochem. | pmid:24620755 |
| Yamanaka K et al. | Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1. | 2014 | Cell Death Dis | pmid:24407243 |
| Gabbi C et al. | Action mechanisms of Liver X Receptors. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24300092 |
| Noguchi N et al. | Diverse functions of 24(S)-hydroxycholesterol in the brain. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24530911 |
| Paul SM et al. | The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. | 2013 | J. Neurosci. | pmid:24174662 |
| Saint-Pol J et al. | Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. | 2013 | Brain Res. | pmid:23603412 |
| Ali Z et al. | On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice. | 2013 | J. Lipid Res. | pmid:23284090 |
| Okabe A et al. | Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death. | 2013 | Redox Biol | pmid:24371802 |
| Acimovic J et al. | Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. | 2013 | PLoS ONE | pmid:23844150 |
| Matsuda A et al. | 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1. | 2013 | J. Neurochem. | pmid:23600914 |
| Urano Y et al. | Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking. | 2013 | FASEB J. | pmid:23839932 |
| Leoni V et al. | Diagnostic power of 24S-hydroxycholesterol in cerebrospinal fluid: candidate marker of brain health. | 2013 | J. Alzheimers Dis. | pmid:23666171 |
| Leoni V and Caccia C | 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases. | 2013 | Biochimie | pmid:23041502 |
| Leoni V et al. | Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression. | 2013 | Neurobiol. Dis. | pmid:23557875 |
| Watanabe K et al. | Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator. | 2013 | Biochem. Pharmacol. | pmid:23732298 |