MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Plaque, Amyloid | D058225 | 19 associated lipids |
Cerebrosterol is a lipid of Sterol Lipids (ST) class. Cerebrosterol is associated with abnormalities such as nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Senile Plaques and Hypercholesterolemia. The involved functions are known as Blood - brain barrier function, Oxidation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, cholesterol biosynthetic process and Anabolism. Cerebrosterol often locates in Hepatic, Body tissue, Autosome, brain tissue surgical material and Tissue membrane. The associated genes with Cerebrosterol are CYP27A1 gene, Alleles, INS gene, Apolipoprotein E4 and PLXNB1 gene. The related lipids are Sterols, 7-dehydrocholesterol, 27-hydroxycholesterol, 24-hydroxycholesterol and Dehydrocholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Cerebrosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cerebrosterol is suspected in Hypercholesterolemia, nervous system disorder, Neurodegenerative Disorders, Alzheimer's Disease, Primary open angle glaucoma, Hypertensive disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cerebrosterol
MeSH term | MeSH ID | Detail |
---|---|---|
Hypercholesterolemia | D006937 | 91 associated lipids |
Alzheimer Disease | D000544 | 76 associated lipids |
Nerve Degeneration | D009410 | 53 associated lipids |
Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.' (Valenza M et al., 2007).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Paul SM et al. | The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. | 2013 | J. Neurosci. | pmid:24174662 |
Saint-Pol J et al. | Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. | 2013 | Brain Res. | pmid:23603412 |
Ali Z et al. | On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice. | 2013 | J. Lipid Res. | pmid:23284090 |
Acimovic J et al. | Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. | 2013 | PLoS ONE | pmid:23844150 |
Matsuda A et al. | 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1. | 2013 | J. Neurochem. | pmid:23600914 |
Urano Y et al. | Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking. | 2013 | FASEB J. | pmid:23839932 |
Leoni V et al. | Diagnostic power of 24S-hydroxycholesterol in cerebrospinal fluid: candidate marker of brain health. | 2013 | J. Alzheimers Dis. | pmid:23666171 |
Leoni V and Caccia C | 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases. | 2013 | Biochimie | pmid:23041502 |
Leoni V et al. | Plasma 24S-hydroxycholesterol correlation with markers of Huntington disease progression. | 2013 | Neurobiol. Dis. | pmid:23557875 |
Watanabe K et al. | Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator. | 2013 | Biochem. Pharmacol. | pmid:23732298 |