7beta-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 7beta-hydroxycholesterol is associated with abnormalities such as Hyperglycemia, Atherosclerosis, Coronary heart disease, Coronary Stenosis and Unstable angina. The involved functions are known as DNA Fragmentation, Apoptosis, Cell Death, Stimulus and caspase activation. 7beta-hydroxycholesterol often locates in Tissue membrane and Frozen Sections. The associated genes with 7beta-Hydroxycholesterol are FGF6 gene. The related lipids are Hydroxycholesterols, Total cholesterol, Sterols, 7-ketocholesterol and Cholestenes.
To understand associated biological information of 7beta-Hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
7beta-Hydroxycholesterol is suspected in Atherosclerosis, Hyperglycemia, Coronary heart disease, Coronary Stenosis, Unstable angina and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 7beta-Hydroxycholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carotid Stenosis | D016893 | 15 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cho HR et al. | 7-Oxygenated cholesterol molecules differentially affect the expression of zonula occludens-1 in vascular smooth muscle cells and monocyte/macrophage cells. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29428726 |
| Cho HR et al. | 7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor. | 2017 | PLoS ONE | pmid:28323848 |
| Deiana M et al. | Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. | 2017 | Free Radic. Biol. Med. | pmid:29102636 |
| Stellaard F et al. | The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27060336 |
| Park SH et al. | α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy. | 2017 | Oncotarget | pmid:28088783 |
| Keune WJ et al. | Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. | 2016 | Nat Commun | pmid:27075612 |
| Musman J et al. | Regular treadmill exercise inhibits mitochondrial accumulation of cholesterol and oxysterols during myocardial ischemia-reperfusion in wild-type and ob/ob mice. | 2016 | Free Radic. Biol. Med. | pmid:27989751 |
| Park SH et al. | Dietary compound α-asarone alleviates ER stress-mediated apoptosis in 7β-hydroxycholesterol-challenged macrophages. | 2016 | Mol Nutr Food Res | pmid:26893256 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Son HH et al. | Hair sterol signatures coupled to multivariate data analysis reveal an increased 7β-hydroxycholesterol production in cognitive impairment. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:26385606 |
| Rasmiena AA et al. | High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein. | 2016 | Biochim. Biophys. Acta | pmid:26569052 |
| Frank DJ et al. | Cytochrome P450 125A4, the Third Cholesterol C-26 Hydroxylase from Mycobacterium smegmatis. | 2015 | Biochemistry | pmid:26522442 |
| Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
| Wang Y et al. | Determination of neuroprotective oxysterols in Calculus bovis, human gallstones, and traditional Chinese medicine preparations by liquid chromatography with mass spectrometry. | 2015 | J Sep Sci | pmid:25545614 |
| Kim SM et al. | 7α-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26474699 |
| Weingärtner O et al. | Vascular effects of oxysterols and oxyphytosterols in apoE -/- mice. | 2015 | Atherosclerosis | pmid:25765595 |
| Kim SM et al. | 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24370436 |
| Helmschrodt C et al. | Preanalytical standardization for reactive oxygen species derived oxysterol analysis in human plasma by liquid chromatography-tandem mass spectrometry. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24370823 |
| Testa G et al. | Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. | 2014 | PLoS ONE | pmid:24802026 |
| Khatib S and Vaya J | Oxysterols and symptomatic versus asymptomatic human atherosclerotic plaque. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24393847 |
| Ikegami T et al. | Increased serum oxysterol concentrations in patients with chronic hepatitis C virus infection. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24525121 |
| Saito Y and Noguchi N | 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24380859 |
| Hammoud Y et al. | Oxysterols modulate calcium signalling in the A7r5 aortic smooth muscle cell-line. | 2013 | Biochimie | pmid:22960205 |
| Hirayama S et al. | Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients. | 2013 | Atherosclerosis | pmid:23958251 |
| Wang SF et al. | 7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. | 2013 | Biochem. Pharmacol. | pmid:23792120 |
| Chung ML et al. | Profiling of oxidized lipid products of marine fish under acute oxidative stress. | 2013 | Food Chem. Toxicol. | pmid:23220612 |
| Mitić T et al. | 11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol. | 2013 | Biochimie | pmid:22940536 |
| Miah S et al. | Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53. | 2013 | Exp. Toxicol. Pathol. | pmid:22999639 |
| Mitić T et al. | 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. | 2013 | Biochem. Pharmacol. | pmid:23415904 |
| Ragot K et al. | Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. | 2013 | Biochem. Pharmacol. | pmid:23473804 |
| Son Y et al. | Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23876312 |
| Loke SY et al. | Comprehensive gene expression analyses of the rat prefrontal cortex after oxysterol treatment. | 2013 | J. Neurochem. | pmid:23294445 |
| Seet RC et al. | Biomarkers of oxidative damage are elevated among individuals with high cardiovascular risk: refining subject selection strategies for antioxidant trials. | 2013 | Free Radic. Res. | pmid:23343456 |
| de Weille J et al. | Similar pyruvate kinase modifications in glioblastoma cells by 7β-hydroxycholesterol and glutamine withdrawal. | 2013 | Biochem. Pharmacol. | pmid:23537700 |
| Laskar A et al. | Fodipir and its dephosphorylated derivative dipyridoxyl ethyldiamine are involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death. | 2013 | Pharmacology | pmid:24080534 |
| Helmschrodt C et al. | Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque. | 2013 | Clin. Chim. Acta | pmid:23827692 |
| Clarion L et al. | 7β-Hydroxycholesterol-induced energy stress leads to sequential opposing signaling responses and to death of C6 glioblastoma cells. | 2012 | Biochem. Pharmacol. | pmid:21983033 |
| Catarino S et al. | Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells. | 2012 | Acta Ophthalmol | pmid:22313893 |
| Li W et al. | Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependent. | 2012 | Free Radic. Biol. Med. | pmid:22985798 |
| Arciello M et al. | Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. | 2012 | Dig Liver Dis | pmid:22154950 |
| Gamba P et al. | Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. | 2011 | Aging Cell | pmid:21272192 |
| Iborra RT et al. | Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. | 2011 | Lipids Health Dis | pmid:21957962 |
| Li W et al. | Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21621514 |
| Seet RC et al. | Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? | 2011 | Free Radic. Biol. Med. | pmid:21420490 |
| Goldman A et al. | The Na+/H+ exchanger controls deoxycholic acid-induced apoptosis by a H+-activated, Na+-dependent ionic shift in esophageal cells. | 2011 | PLoS ONE | pmid:21887327 |
| Jusakul A et al. | Mechanisms of oxysterol-induced carcinogenesis. | 2011 | Lipids Health Dis | pmid:21388551 |
| Liu C et al. | Oxysterols direct B-cell migration through EBI2. | 2011 | Nature | pmid:21796211 |
| Vestergaard MC et al. | The effect of oxycholesterols on thermo-induced membrane dynamics. | 2011 | Biochim. Biophys. Acta | pmid:21600872 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Tang Z and Guengerich FP | Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts. | 2010 | Anal. Chem. | pmid:20795636 |