MeSH term | MeSH ID | Detail |
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Keloid | D007627 | 12 associated lipids |
Cucurbitacin i is a lipid of Sterol Lipids (ST) class. Cucurbitacin i is associated with abnormalities such as Corn of toe, Keloid, Nodule, Pneumonia, unspecified organism and Wiskott-Aldrich Syndrome. The involved functions are known as metaplastic cell transformation, Metabolic Inhibition, Apoptosis, anti-apoptosis and RNA Interference. Cucurbitacin i often locates in Protoplasm, Body tissue, Cytoskeleton, Neck and Transplanted tissue. The associated genes with Cucurbitacin I are STAT3 gene, JAK2 gene, BCL2L1 gene, BCL2 gene and Candidate Disease Gene. The related experimental models are Breast Cancer Model and Cancer Model.
To understand associated biological information of Cucurbitacin I, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Cucurbitacin I is suspected in Corn of toe, Keloid, Nodule, Pneumonia, unspecified organism and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Cucurbitacin I
MeSH term | MeSH ID | Detail |
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Keloid | D007627 | 12 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin I through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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Breast Cancer Model are used in the study 'Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells.' (Lui VW et al., 2009).
Cancer Model are used in the study 'Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells.' (Lui VW et al., 2009).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Oi T et al. | STAT3 inhibitor, cucurbitacin I, is a novel therapeutic agent for osteosarcoma. | 2016 | Int. J. Oncol. | pmid:27840900 |
Pan T et al. | 17β-Oestradiol enhances the expansion and activation of myeloid-derived suppressor cells via signal transducer and activator of transcription (STAT)-3 signalling in human pregnancy. | 2016 | Clin. Exp. Immunol. | pmid:26969967 |
Deng C et al. | Low nanomolar concentrations of Cucurbitacin-I induces G2/M phase arrest and apoptosis by perturbing redox homeostasis in gastric cancer cells in vitro and in vivo. | 2016 | Cell Death Dis | pmid:26890145 |
Wu Y et al. | Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway. | 2016 | Toxicol. Lett. | pmid:27836799 |
Nguyen BC et al. | Combination of immunoprecipitation (IP)-ATP_Glo kinase assay and melanogenesis for the assessment of potent and safe PAK1-blockers in cell culture. | 2015 | Drug Discov Ther | pmid:26370527 |
Jeong MH et al. | Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. | 2015 | PLoS ONE | pmid:26296085 |
Yuan G et al. | JSI-124 suppresses invasion and angiogenesis of glioblastoma cells in vitro. | 2015 | PLoS ONE | pmid:25789853 |
Premkumar DR et al. | Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells. | 2015 | Cancer Biol. Ther. | pmid:25482928 |
Hira SK et al. | Downregulation of STAT3 phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-α. | 2015 | Int. J. Biochem. Cell Biol. | pmid:26255115 |
Park JB et al. | Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway. | 2014 | Oncotarget | pmid:25237832 |