Cucurbitacin I

Cucurbitacin i is a lipid of Sterol Lipids (ST) class. Cucurbitacin i is associated with abnormalities such as Corn of toe, Keloid, Nodule, Pneumonia, unspecified organism and Wiskott-Aldrich Syndrome. The involved functions are known as metaplastic cell transformation, Metabolic Inhibition, Apoptosis, anti-apoptosis and RNA Interference. Cucurbitacin i often locates in Protoplasm, Body tissue, Cytoskeleton, Neck and Transplanted tissue. The associated genes with Cucurbitacin I are STAT3 gene, JAK2 gene, BCL2L1 gene, BCL2 gene and Candidate Disease Gene. The related experimental models are Breast Cancer Model and Cancer Model.

Cross Reference

Introduction

To understand associated biological information of Cucurbitacin I, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Cucurbitacin I?

Cucurbitacin I is suspected in Corn of toe, Keloid, Nodule, Pneumonia, unspecified organism and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Cucurbitacin I

MeSH term MeSH ID Detail
Keloid D007627 12 associated lipids
Total 1

PubChem Associated disorders and diseases

What pathways are associated with Cucurbitacin I

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Cucurbitacin I through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Cucurbitacin I?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Cucurbitacin I?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Cucurbitacin I?

There are no associated biomedical information in the current reference collection.

What genes are associated with Cucurbitacin I?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Cucurbitacin I?

Breast Cancer Model

Breast Cancer Model are used in the study 'Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells.' (Lui VW et al., 2009).

Cancer Model

Cancer Model are used in the study 'Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells.' (Lui VW et al., 2009).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Cucurbitacin I

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Authors Title Published Journal PubMed Link
Oi T et al. STAT3 inhibitor, cucurbitacin I, is a novel therapeutic agent for osteosarcoma. 2016 Int. J. Oncol. pmid:27840900
Pan T et al. 17β-Oestradiol enhances the expansion and activation of myeloid-derived suppressor cells via signal transducer and activator of transcription (STAT)-3 signalling in human pregnancy. 2016 Clin. Exp. Immunol. pmid:26969967
Deng C et al. Low nanomolar concentrations of Cucurbitacin-I induces G2/M phase arrest and apoptosis by perturbing redox homeostasis in gastric cancer cells in vitro and in vivo. 2016 Cell Death Dis pmid:26890145
Wu Y et al. Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway. 2016 Toxicol. Lett. pmid:27836799
Nguyen BC et al. Combination of immunoprecipitation (IP)-ATP_Glo kinase assay and melanogenesis for the assessment of potent and safe PAK1-blockers in cell culture. 2015 Drug Discov Ther pmid:26370527
Jeong MH et al. Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. 2015 PLoS ONE pmid:26296085
Yuan G et al. JSI-124 suppresses invasion and angiogenesis of glioblastoma cells in vitro. 2015 PLoS ONE pmid:25789853
Premkumar DR et al. Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells. 2015 Cancer Biol. Ther. pmid:25482928
Hira SK et al. Downregulation of STAT3 phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-α. 2015 Int. J. Biochem. Cell Biol. pmid:26255115
Park JB et al. Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway. 2014 Oncotarget pmid:25237832