4-hydroxynonenal

4-hydroxynonenal is a lipid of Fatty Acyls (FA) class. 4-hydroxynonenal is associated with abnormalities such as Chronic disease, Obesity, Diabetes, Acquired Immunodeficiency Syndrome and Lung diseases. The involved functions are known as protein expression, Glycolysis, mRNA Expression, Regulation and Mitochondrion in division. 4-hydroxynonenal often locates in Muscle, Mitochondria, Adipose tissue, Head and Mouse Muscle. The associated genes with 4-hydroxynonenal are STAT3 gene, SIRT1 gene, PGC gene, IL6 gene and cytochrome c''. The related lipids are Lipopolysaccharides, Lipid Peroxides, Promega, Membrane Lipids and oxidized lipid. The related experimental models are Mouse Model, Knock-out, Transgenic Model, Disease model and Rodent Model.

Cross Reference

Introduction

To understand associated biological information of 4-hydroxynonenal, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 4-hydroxynonenal?

4-hydroxynonenal is suspected in Ischemia, Atherosclerosis, Alzheimer's Disease, Diabetes, Parkinson Disease, Obesity and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-hydroxynonenal

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hyperglycemia D006943 21 associated lipids
Per page 10 20 50 100 | Total 174

PubChem Associated disorders and diseases

What pathways are associated with 4-hydroxynonenal

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 4-hydroxynonenal?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 4-hydroxynonenal?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 4-hydroxynonenal?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 4-hydroxynonenal?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 4-hydroxynonenal?

Knock-out

Knock-out are used in the study 'Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.' (Singhal SS et al., 2015), Knock-out are used in the study 'Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice.' (Sun A et al., 2014), Knock-out are used in the study 'Disruption of the mGsta4 gene increases life span of C57BL mice.' (Singh SP et al., 2010), Knock-out are used in the study 'On the role of 4-hydroxynonenal in health and disease.' (Csala M et al., 2015) and Knock-out are used in the study 'Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-α double knockout mice enhance injury during early stages of alcoholic liver disease.' (Ronis MJ et al., 2015).

Mouse Model

Mouse Model are used in the study 'Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage.' (Liu Q et al., 2007).

Transgenic Model

Transgenic Model are used in the study 'Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina.' (Tanito M et al., 2005).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with 4-hydroxynonenal

Download all related citations
Per page 10 20 50 100 | Total 2778
Authors Title Published Journal PubMed Link
Ding L et al. Danshen protects against early-stage alcoholic liver disease in mice via inducing PPARα activation and subsequent 4-HNE degradation. 2017 PLoS ONE pmid:29020055
Hu JN et al. Ameliorative Effects and Possible Molecular Mechanism of Action of Black Ginseng (Panax ginseng) on Acetaminophen-Mediated Liver Injury. 2017 Molecules pmid:28430162
Yeh TY et al. Effects of epidural compression on stellate neurons and thalamocortical afferent fibers in the rat primary somatosensory cortex. 2017 Acta Neurobiol Exp (Wars) pmid:28379212
Stachowicz A et al. Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). 2017 Int J Mol Sci pmid:28218653
Xiao M et al. Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria. 2017 Free Radic. Biol. Med. pmid:28456642
Zhao X et al. Polydatin protects against carbon tetrachloride-induced liver fibrosis in mice. 2017 Arch. Biochem. Biophys. pmid:28666738
Moon JY et al. α-Syntrophin stabilizes catalase to reduce endogenous reactive oxygen species levels during myoblast differentiation. 2017 FEBS J. pmid:28485891
Vazdar K et al. Reaction Mechanism of Covalent Modification of Phosphatidylethanolamine Lipids by Reactive Aldehydes 4-Hydroxy-2-nonenal and 4-Oxo-2-nonenal. 2017 Chem. Res. Toxicol. pmid:28222263
Zhong H et al. Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer. 2017 Free Radic. Biol. Med. pmid:27838437
Ebenezer DL et al. Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. 2017 Adv Biol Regul pmid:27720306