Alpha-parinaric acid

Alpha-parinaric acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 712 references associated with Alpha-parinaric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Alpha-parinaric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Alpha-parinaric acid

MeSH term MeSH ID Detail
Arteriosclerosis D001161 86 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Total 3

All references with Alpha-parinaric acid

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Authors Title Published Journal PubMed Link
Modriansky M et al. Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants? 2002 Toxicology pmid:12126799
Zsila F and Bikádi Z trans-Parinaric acid as a versatile spectroscopic label to study ligand binding properties of bovine beta-lactoglobulin. 2005 Spectrochim Acta A Mol Biomol Spectrosc pmid:15893954
Imre T et al. Electrospray mass spectrometric investigation of the binding of cis-parinaric acid to bovine beta-lactoglobulin and study of the ligand-binding site of the protein using limited proteolysis. 2003 Rapid Commun. Mass Spectrom. pmid:14608614
Leung G and Moody AR MR imaging depicts oxidative stress induced by methemoglobin. 2010 Radiology pmid:20829533
Velkov T et al. Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain. 2010 Protein Expr. Purif. pmid:19782138
Petrescu AD et al. Structural and functional characterization of a new recombinant histidine-tagged acyl coenzyme A binding protein (ACBP) from mouse. 2008 Protein Expr. Purif. pmid:18178100
Tribble DL et al. Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8302851
Haldar S et al. Inactivation of Bcl-2 by phosphorylation. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7753834
Cheng X et al. Molecular characterization and functions of fatty acid and retinoid binding protein gene (Ab-far-1) in Aphelenchoides besseyi. 2013 PLoS ONE pmid:23755297
Cho KW et al. Fluorescent polyene aliphatics as spectroscopic and mechanistic probes for bacterial luciferase: evidence against carbonyl product from aldehyde as the primary excited species. 1993 Photochem. Photobiol. pmid:8451303
Traynelis VC et al. Cytotoxicity of cis-parinaric acid in cultured malignant gliomas. 1995 Neurosurgery pmid:7501114
Sun AY et al. Ethanol-induced cell death by lipid peroxidation in PC12 cells. 1997 Neurochem. Res. pmid:9342721
Zaheer A et al. Cis-parinaric acid effects, cytotoxicity, c-Jun N-terminal protein kinase, forkhead transcription factor and Mn-SOD differentially in malignant and normal astrocytes. 2007 Neurochem. Res. pmid:17160503
Lawrence JF et al. An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. 1994 Nat. Toxins pmid:7866668
van Meer G and Liskamp RM Brilliant lipids. 2005 Nat. Methods pmid:15782165
Reddy AS and Thomas TL Expression of a cyanobacterial delta 6-desaturase gene results in gamma-linolenic acid production in transgenic plants. 1996 Nat. Biotechnol. pmid:9630958
Heyliger CE et al. Characteristics of the myocardial PM-FABP: effect of diabetes mellitus. 1997 Mol. Cell. Biochem. pmid:9406173
Fraser H et al. Fatty acid uptake in diabetic rat adipocytes. 1997 Mol. Cell. Biochem. pmid:9059981
Huang J and May JM Ascorbic acid spares alpha-tocopherol and prevents lipid peroxidation in cultured H4IIE liver cells. 2003 Mol. Cell. Biochem. pmid:12841645
Cook D et al. Modification of fatty acid composition in tomato (Lycopersicon esculentum) by expression of a borage delta6-desaturase. 2002 Mol. Biotechnol. pmid:12059112
Kagan VE et al. Sensitive and specific fluorescent probing of oxidative stress in different classes of membrane phospholipids in live cells using metabolically integrated cis-parinaric acid. 1998 Methods Mol. Biol. pmid:9921517
Brunaldi K et al. Fluorescence assays for measuring fatty acid binding and transport through membranes. 2007 Methods Mol. Biol. pmid:17951738
Kagan VE et al. Assay of ubiquinones and ubiquinols as antioxidants. 1994 Meth. Enzymol. pmid:7808306
Tsuchiya M et al. Antioxidant activity of alpha-tocopherol, beta-carotene, and ubiquinol in membranes: cis-parinaric acid-incorporated liposomes. 1994 Meth. Enzymol. pmid:7808309
Nyholm TK et al. Construction of a DOPC/PSM/cholesterol phase diagram based on the fluorescence properties of trans-parinaric acid. 2011 Langmuir pmid:21627141
Engberg O et al. Effects of cholesterol and saturated sphingolipids on acyl chain order in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine bilayers--a comparative study with phase-selective fluorophores. 2015 Langmuir pmid:25806833
Arai S et al. Effects of antioxidants on induction of apoptosis in bursal cells of Fabricius during in vitro cultivation. 2000 J. Vet. Med. Sci. pmid:10676888
Bhattacharyya J et al. Evaluation of hydrophobicity versus chaperonelike activity of bovine alphaA- and alphaB-crystallin. 2002 J. Protein Chem. pmid:11902669
McMillan DC et al. Role of lipid peroxidation in dapsone-induced hemolytic anemia. 1998 J. Pharmacol. Exp. Ther. pmid:9864266
Huang J et al. Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells. 2004 J. Nutr. Biochem. pmid:15607645
Rimoldi OJ et al. Purification and properties of the very high density lipoprotein from the hemolymph of adult Triatoma infestans. 1989 J. Lipid Res. pmid:2677201
Shvedova AA et al. Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxide. 2002 J. Invest. Dermatol. pmid:12060396
Shvedova AA et al. Redox cycling of phenol induces oxidative stress in human epidermal keratinocytes. 2000 J. Invest. Dermatol. pmid:10651998
Martin GG et al. Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene. 2003 J. Biol. Chem. pmid:12670956
Kueltzo LA et al. Conformational lability of herpesvirus protein VP22. 2000 J. Biol. Chem. pmid:10913125
Aresta-Branco F et al. Gel domains in the plasma membrane of Saccharomyces cerevisiae: highly ordered, ergosterol-free, and sphingolipid-enriched lipid rafts. 2011 J. Biol. Chem. pmid:21127065
Hostetler HA et al. Peroxisome proliferator-activated receptor alpha interacts with high affinity and is conformationally responsive to endogenous ligands. 2005 J. Biol. Chem. pmid:15774422
Tyagi SC and Simon SR Parinaric acids as probes of binding domains in neutrophil elastase. 1991 J. Biol. Chem. pmid:1869548
Nemecz G et al. Polyene fatty acid interactions with recombinant intestinal and liver fatty acid-binding proteins. Spectroscopic studies. 1991 J. Biol. Chem. pmid:1894608
Badwey JA et al. Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. 1984 J. Biol. Chem. pmid:6330088
Rujanavech C et al. Influence of sterol structure on phospholipid phase behavior as detected by parinaric acid fluorescence spectroscopy. 1986 J. Biol. Chem. pmid:3711085
Hsia JC and Kwan NH Human serum albumin: binding specificity and allosteric effect of parinarate and stearate. A dianionic spin label study. 1981 J. Biol. Chem. pmid:6257712
Petrescu AD et al. Role of regulatory F-domain in hepatocyte nuclear factor-4alpha ligand specificity. 2005 J. Biol. Chem. pmid:15741159
Tecoma ES and Wu D Membrane deenergization by colicin K affects fluorescence of exogenously added but not biosynthetically esterified parinaric acid probes in Escherichia coli. 1980 J. Bacteriol. pmid:6991495
Yang J et al. Hydrophobic probe binding of beta-lactoglobulin in the native and molten globule state induced by high pressure as affected by pH, KIO(3) and N-ethylmaleimide. 2002 J. Agric. Food Chem. pmid:12188631
Epperly MW et al. Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation. 2001 Int. J. Cancer pmid:11474496
Omaye ST et al. beta-carotene: friend or foe? 1997 Fundam Appl Toxicol pmid:9441712
Pearson DC et al. The anti-oxidant properties of 5-aminosalicylic acid. 1996 Free Radic. Biol. Med. pmid:8855448
Ross D et al. Ascorbate 6-palmitate protects human erythrocytes from oxidative damage. 1999 Free Radic. Biol. Med. pmid:9890643
Wiseman SA et al. Comparison of the effects of dietary vitamin E on in vivo and in vitro parameters of lipid peroxidation in the rabbit. 1995 Free Radic. Biol. Med. pmid:8529921

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