4-hydroxy-butyric acid

4-hydroxy-butyric acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 8613 references associated with 4-hydroxy-butyric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for 4-hydroxy-butyric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-hydroxy-butyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Coronary Disease D003327 70 associated lipids
Substance Withdrawal Syndrome D013375 9 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Muscular Dystrophies D009136 10 associated lipids
Femoral Fractures D005264 7 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Intellectual Disability D008607 13 associated lipids
Glioma D005910 112 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Myocardial Infarction D009203 21 associated lipids
Peritonitis D010538 38 associated lipids
Cardiac Complexes, Premature D005117 6 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Glaucoma D005901 5 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Ataxia D001259 20 associated lipids
Alcoholism D000437 27 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Starvation D013217 47 associated lipids
Brain Ischemia D002545 89 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Peptic Ulcer D010437 19 associated lipids
Hypertension D006973 115 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cerebral Infarction D002544 6 associated lipids
Fever D005334 35 associated lipids
Catalepsy D002375 30 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Radiation Injuries, Experimental D011833 11 associated lipids
Shock, Traumatic D012774 4 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Tremor D014202 15 associated lipids
Parkinson Disease D010300 53 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Psychomotor Disorders D011596 3 associated lipids
Poisoning D011041 9 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Muscular Dystrophy, Animal D009137 5 associated lipids
Cystadenocarcinoma D003536 3 associated lipids
Meningitis, Meningococcal D008585 2 associated lipids
Cataplexy D002385 2 associated lipids
Narcolepsy D009290 1 associated lipids
Dysgerminoma D004407 1 associated lipids
Language Development Disorders D007805 4 associated lipids
Cardiomyopathy, Alcoholic D002310 1 associated lipids
Uterine Inertia D014593 3 associated lipids
Abortion, Threatened D000033 2 associated lipids
Leukoencephalopathy, Progressive Multifocal D007968 1 associated lipids
Distemper D004216 1 associated lipids
Pseudotumor Cerebri D011559 2 associated lipids
Hallucinations D006212 4 associated lipids
Heat Exhaustion D006359 1 associated lipids
Myoclonus D009207 3 associated lipids
Spinal Cord Diseases D013118 4 associated lipids
Abdominal Neoplasms D000008 1 associated lipids
Sertoli-Leydig Cell Tumor D018310 1 associated lipids
Sleep Wake Disorders D012893 7 associated lipids
Burkholderia Infections D019121 7 associated lipids
Granulosa Cell Tumor D006106 1 associated lipids
Epilepsy, Absence D004832 5 associated lipids
Rheumatic Heart Disease D012214 1 associated lipids
Decerebrate State D003655 7 associated lipids
Pericarditis D010493 6 associated lipids
Spermatic Cord Torsion D013086 1 associated lipids
Alcohol Withdrawal Delirium D000430 1 associated lipids
Psychoses, Alcoholic D011604 2 associated lipids
Heart Septal Defects, Atrial D006344 1 associated lipids
Sleep Apnea Syndromes D012891 3 associated lipids
Disorders of Excessive Somnolence D006970 1 associated lipids
Amnesia D000647 12 associated lipids
Amnesia, Retrograde D000648 2 associated lipids
Fluoride Poisoning D005458 1 associated lipids
Drug Overdose D062787 2 associated lipids
Language Disorders D007806 1 associated lipids
Cocaine-Related Disorders D019970 3 associated lipids
Sleep Disorders, Circadian Rhythm D020178 3 associated lipids
Akathisia, Drug-Induced D017109 2 associated lipids
Autonomic Nervous System Diseases D001342 4 associated lipids
Heroin Dependence D006556 1 associated lipids
Alcohol-Related Disorders D019973 3 associated lipids
Consciousness Disorders D003244 2 associated lipids
Epilepsies, Myoclonic D004831 2 associated lipids
Alcohol Withdrawal Seizures D020270 1 associated lipids
Per page 10 20 50 100 | Total 113

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 4-hydroxy-butyric acid

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Per page 10 20 50 100 | Total 3045
Authors Title Published Journal PubMed Link
Wang HH et al. Biosynthesis of polyhydroxyalkanoate homopolymers by Pseudomonas putida. 2011 Appl. Microbiol. Biotechnol. pmid:21046374
Lane T et al. High HIV prevalence among men who have sex with men in Soweto, South Africa: results from the Soweto Men's Study. 2011 AIDS Behav pmid:19662523
Zhang X and Chen G [Enzymes related with NAD synthesis promote conversion of 1,4-butanediol to 4-hydroxybutyrate]. 2011 Sheng Wu Gong Cheng Xue Bao pmid:22506415
Esse K et al. Epidemic of illicit drug use, mechanisms of action/addiction and stroke as a health hazard. 2011 Brain Behav pmid:22398980
Bramness JG and Haugland S [Abuse of γ-hydroxybutyrate]. 2011 Tidsskr. Nor. Laegeforen. pmid:22048208
Arendt EK et al. Medical nutrition therapy: use of sourdough lactic acid bacteria as a cell factory for delivering functional biomolecules and food ingredients in gluten free bread. 2011 Microb. Cell Fact. pmid:21995616
Payne CM et al. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. 2011 Clin Exp Gastroenterol pmid:21753893
Mendes AA et al. Immobilization of a Commercial Lipase from Penicillium camembertii (Lipase G) by Different Strategies. 2011 Enzyme Res pmid:21811674
Brummett CM and Clauw DJ Fibromyalgia: a primer for the anesthesia community. 2011 Curr Opin Anaesthesiol pmid:21799404
Poli A et al. Synthesis, production, and biotechnological applications of exopolysaccharides and polyhydroxyalkanoates by archaea. 2011 Archaea pmid:22007151
Fulton HG et al. The relationship between self-reported substance use and psychiatric symptoms in low-threshold methadone maintenance treatment clients. 2011 Harm Reduct J pmid:21798056
Yelamanchili SV et al. Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism. 2011 Mol Neurodegener pmid:21777416
Li W and Liu M Distribution of 5-hydroxymethylcytosine in different human tissues. 2011 J Nucleic Acids pmid:21772996
Smith HS et al. Pharmacotherapy for fibromyalgia. 2011 Front Pharmacol pmid:21772818
Schmidt M et al. Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial. 2011 Nutr Metab (Lond) pmid:21794124
Chablais F et al. The zebrafish heart regenerates after cryoinjury-induced myocardial infarction. 2011 BMC Dev. Biol. pmid:21473762
Donjacour CE et al. Effect of sodium oxybate on growth hormone secretion in narcolepsy patients and healthy controls. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21447786
Utsumi Y et al. Functional diversity of isoamylase oligomers: the ISA1 homo-oligomer is essential for amylopectin biosynthesis in rice endosperm. 2011 Plant Physiol. pmid:21436381
Moldofsky H and Patcai J Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study. 2011 BMC Neurol pmid:21435231
Minic Z and Thongbam PD The biological deep sea hydrothermal vent as a model to study carbon dioxide capturing enzymes. 2011 Mar Drugs pmid:21673885
Soo JK et al. Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression. 2011 Pigment Cell Melanoma Res pmid:21418545
Amato L et al. Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome. 2011 Cochrane Database Syst Rev pmid:21678378
Urquhart W et al. The cyclic nucleotide-gated channels AtCNGC11 and 12 are involved in multiple Ca²⁺-dependent physiological responses and act in a synergistic manner. 2011 J. Exp. Bot. pmid:21414958
De Paoli G et al. Endogenous γ-hydroxybutyric acid concentrations in saliva determined by gas chromatography-mass spectrometry. 2011 J Anal Toxicol pmid:21439150
Poryazova R et al. Sodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience. 2011 Eur. Neurol. pmid:21389728
Meyer MR et al. A validated GC-MS procedure for fast, simple, and cost-effective quantification of glycols and GHB in human plasma and their identification in urine and plasma developed for emergency toxicology. 2011 Anal Bioanal Chem pmid:21336790
Pujalté I et al. Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells. 2011 Part Fibre Toxicol pmid:21371295
Andresen H et al. An overview of gamma-hydroxybutyric acid: pharmacodynamics, pharmacokinetics, toxic effects, addiction, analytical methods, and interpretation of results. 2011 Drug Test Anal pmid:21381220
Felmlee MA et al. Use of a local sensitivity analysis to inform study design based on a mechanistic toxicokinetic model for γ-hydroxybutyric acid. 2011 AAPS J pmid:21387146
Marclay F et al. Source inference of exogenous gamma-hydroxybutyric acid (GHB) administered to humans by means of carbon isotopic ratio analysis: novel perspectives regarding forensic investigation and intelligence issues. 2011 Anal Bioanal Chem pmid:21455654
Cagnin A et al. γ-Hydroxybutyric acid-induced psychosis and seizures. 2011 Epilepsy Behav pmid:21530412
Maurer GD et al. Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. 2011 BMC Cancer pmid:21791085
Dabbish NS and Raizen DM GABAergic synaptic plasticity during a developmentally regulated sleep-like state in C. elegans. 2011 J. Neurosci. pmid:22049436
Ellison CT et al. XAP5 CIRCADIAN TIMEKEEPER regulates ethylene responses in aerial tissues of Arabidopsis. 2011 Plant Physiol. pmid:21163961
Donjacour CE et al. Sodium oxybate increases prolactin secretion in narcolepsy patients and healthy controls. 2011 Eur. J. Endocrinol. pmid:21148631
Juchimiuk-Kwasniewska J et al. FISH in analysis of gamma ray-induced micronuclei formation in barley. 2011 J. Appl. Genet. pmid:21136232
Spitzer AR and Broadman M Treatment of the narcoleptiform sleep disorder in chronic fatigue syndrome and fibromyalgia with sodium oxybate. 2010 Jan-Feb Pain Pract pmid:20629967
Singh H et al. Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones. 2010 Apr-Jun Sci Pharm pmid:21179341
Oh SA et al. The tobacco MAP215/Dis1-family protein TMBP200 is required for the functional organization of microtubule arrays during male germline establishment. 2010 J. Exp. Bot. pmid:20022922
Feldman NT Clinical perspective: monitoring sodium oxybate-treated narcolepsy patients for the development of sleep-disordered breathing. 2010 Sleep Breath pmid:19626356
Ren Q et al. Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives. 2010 Appl. Microbiol. Biotechnol. pmid:20393709
Kirmse K et al. GABA depolarizes immature neocortical neurons in the presence of the ketone body ß-hydroxybutyrate. 2010 J. Neurosci. pmid:21106838
Likić VA et al. Systems biology: the next frontier for bioinformatics. 2010 Adv Bioinformatics pmid:21331364
Ingels AS et al. Determination of gamma-hydroxybutyric acid in dried blood spots using a simple GC-MS method with direct "on spot" derivatization. 2010 Anal Bioanal Chem pmid:20835862
Berg IA et al. Study of the distribution of autotrophic CO2 fixation cycles in Crenarchaeota. 2010 Microbiology (Reading, Engl.) pmid:19850614
Young SA and Smith TK The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei. 2010 Mol. Microbiol. pmid:20398210
Mandáková T et al. Fast diploidization in close mesopolyploid relatives of Arabidopsis. 2010 Plant Cell pmid:20639445
Zeng W et al. A glucurono(arabino)xylan synthase complex from wheat contains members of the GT43, GT47, and GT75 families and functions cooperatively. 2010 Plant Physiol. pmid:20631319
Koek W et al. GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo. 2010 J. Pharmacol. Exp. Ther. pmid:20628000
Covey PA et al. A pollen-specific RALF from tomato that regulates pollen tube elongation. 2010 Plant Physiol. pmid:20388667