| MeSH term | MeSH ID | Detail |
|---|---|---|
| Miosis | D015877 | 4 associated lipids |
| Mydriasis | D015878 | 2 associated lipids |
| Speech Disorders | D013064 | 1 associated lipids |
4-hydroxy-butyric acid
4-hydroxy-butyric acid is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 8613 references associated with 4-hydroxy-butyric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
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Here are additional resources we collected from PubChem and MeSH for 4-hydroxy-butyric acid
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 4-hydroxy-butyric acid
PubChem Associated disorders and diseases
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NCBI Entrez Crosslinks
All references with 4-hydroxy-butyric acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| El-Habr EA et al. | A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma. | 2017 | Acta Neuropathol. | pmid:28032215 |
| Busardò FP et al. | Assessment of the stability of exogenous gamma hydroxybutyric acid (GHB) in stored blood and urine specimens. | 2015 | Eur Rev Med Pharmacol Sci | pmid:26592846 |
| Kim M et al. | Two pathways for glutamate biosynthesis in the syntrophic bacterium Syntrophus aciditrophicus. | 2015 | Appl. Environ. Microbiol. | pmid:26431966 |
| Dave RA and Morris ME | Semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated renal reabsorption: pharmacokinetics of γ-hydroxybutyric acid and L-lactate in rats. | 2015 | J Pharmacokinet Pharmacodyn | pmid:26341876 |
| Bosch OG et al. | Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone. | 2015 | Psychoneuroendocrinology | pmid:26209926 |
| Kawase T et al. | Novel fluorinated gemini surfactants with γ-butyrolactone segments. | 2015 | J Oleo Sci | pmid:25748377 |
| Otte J et al. | Malonic semialdehyde reductase from the archaeon Nitrosopumilus maritimus is involved in the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle. | 2015 | Appl. Environ. Microbiol. | pmid:25548047 |
| Luca G et al. | Central and peripheral metabolic changes induced by gamma-hydroxybutyrate. | 2015 | Sleep | pmid:25515097 |
| Claussen MC et al. | Catatonic stupor secondary to gamma-hydroxy-butyric acid (GHB)-dependence and -withdrawal syndrome. | 2014 | Psychiatr Danub | pmid:25377371 |
| Gould T et al. | GABA(B) receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid. | 2014 | Philos. Trans. R. Soc. Lond., B, Biol. Sci. | pmid:25225100 |
| Vijay N and Morris ME | Effect of 3,4-methylenedioxymethamphetamine on the toxicokinetics and sedative effects of the drug of abuse, γ-hydroxybutyric acid. | 2014 | J Pharm Sci | pmid:25174723 |
| Cheung J et al. | γ-Hydroxybutyric acid-induced electrographic seizures. | 2014 | J Clin Sleep Med | pmid:25024661 |
| Wendt G et al. | Gamma-hydroxybutyrate, acting through an anti-apoptotic mechanism, protects native and amyloid-precursor-protein-transfected neuroblastoma cells against oxidative stress-induced death. | 2014 | Neuroscience | pmid:24456637 |
| Zhai D et al. | Development of a fluorescent sensor for illicit date rape drug GHB. | 2014 | Chem. Commun. (Camb.) | pmid:24492471 |
| Kamal RM et al. | Decision rules for GHB (γ-hydroxybutyric acid) detoxification: a vignette study. | 2014 | Drug Alcohol Depend | pmid:24380737 |
| Krishnamurthy VB et al. | An interesting case of late age at onset of narcolepsy with cataplexy. | 2014 | J Clin Sleep Med | pmid:24533004 |
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| Black SW et al. | GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy. | 2014 | J. Neurosci. | pmid:24806675 |
| Yiu CY et al. | Inhibition of Epstein-Barr virus lytic cycle by an ethyl acetate subfraction separated from Polygonum cuspidatum root and its major component, emodin. | 2014 | Molecules | pmid:24448066 |
| Eghorn LF et al. | Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin. | 2014 | Eur. J. Pharmacol. | pmid:24973695 |
| Goodwin AK et al. | Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons. | 2013 | Psychopharmacology (Berl.) | pmid:22945514 |
| Johnson MW and Griffiths RR | Comparative abuse liability of GHB and ethanol in humans. | 2013 | Exp Clin Psychopharmacol | pmid:23421353 |
| Petersen IN et al. | Identification of a new metabolite of GHB: gamma-hydroxybutyric acid glucuronide. | 2013 | J Anal Toxicol | pmid:23612681 |
| Ingels AS et al. | Determination of gamma-hydroxybutyric acid in biofluids using a one-step procedure with "in-vial" derivatization and headspace-trap gas chromatography-mass spectrometry. | 2013 | J Chromatogr A | pmid:23664352 |
| Rosi L et al. | Determination of GHB and its precursors (GBL and 1,4-BD) in dietary supplements through the synthesis of their isotopologues and analysis by GC-MS method. | 2013 | J Pharm Biomed Anal | pmid:23245230 |
| Hawkins AS et al. | Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea. | 2013 | J. Biol. Chem. | pmid:23258541 |
| Munshi T et al. | Monitoring of the interconversion of gamma-butyrolactone (GBL) to gamma hydroxybutyric acid (GHB) by Raman spectroscopy. | 2013 | Drug Test Anal | pmid:23225646 |
| Amer B et al. | Novel GHB-derived natural products from European mistletoe (Viscum album). | 2013 | Pharm Biol | pmid:23734579 |
| de Jong CA et al. | Treatment of GHB withdrawal syndrome: Catch 22 or challenge for addiction medicine? | 2013 | Addiction | pmid:23718746 |
| Choi S et al. | Production of 4-hydroxybutyric acid by metabolically engineered Mannheimia succiniciproducens and its conversion to γ-butyrolactone by acid treatment. | 2013 | Metab. Eng. | pmid:24055777 |
| Liu X et al. | The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes. | 2013 | Neuropharmacology | pmid:23665355 |
| Forni S et al. | Quantitation of gamma-hydroxybutyric acid in dried blood spots: feasibility assessment for newborn screening of succinic semialdehyde dehydrogenase (SSADH) deficiency. | 2013 | Mol. Genet. Metab. | pmid:23742746 |
| Hermann-Krauss C et al. | Archaeal production of polyhydroxyalkanoate (PHA) co- and terpolyesters from biodiesel industry-derived by-products. | 2013 | Archaea | pmid:24453697 |
| Vogensen SB et al. | New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites. | 2013 | J. Med. Chem. | pmid:24053696 |
| Spaeth M et al. | Long-term tolerability and maintenance of therapeutic response to sodium oxybate in an open-label extension study in patients with fibromyalgia. | 2013 | Arthritis Res. Ther. | pmid:24286114 |
| Fordahl S et al. | Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors. | 2012 Jan-Feb | Neurotoxicol Teratol | pmid:22056924 |
| Mignot EJ | A practical guide to the therapy of narcolepsy and hypersomnia syndromes. | 2012 | Neurotherapeutics | pmid:23065655 |
| Dematteis M et al. | [Current knowledge on gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL) and 1 ,4-butanediol (1,4-BD)]. | 2012 | Rev Prat | pmid:22730800 |
| Absalom N et al. | α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22753476 |
| van Amsterdam JG et al. | Risk assessment of gamma-hydroxybutyric acid (GHB) in the Netherlands. | 2012 | Regul. Toxicol. Pharmacol. | pmid:22440552 |
| Zhou Q et al. | [Application of high efficiency promoters in microbial production of 4-hydroxybutyric acid]. | 2012 | Sheng Wu Gong Cheng Xue Bao | pmid:22667108 |
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| Krueger T and Melendez P | Effect of ghrelin on feed intake and metabolites in lambs. | 2012 | Appetite | pmid:22280977 |
| Wippel K and Sauer N | Arabidopsis SUC1 loads the phloem in suc2 mutants when expressed from the SUC2 promoter. | 2012 | J. Exp. Bot. | pmid:22021573 |
| Dahl SR et al. | Determination of γ-hydroxybutyrate (GHB), β-hydroxybutyrate (BHB), pregabalin, 1,4-butane-diol (1,4BD) and γ-butyrolactone (GBL) in whole blood and urine samples by UPLC-MSMS. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22226469 |
| Dickerson DL and Johnson CL | Mental health and substance abuse characteristics among a clinical sample of urban American Indian/Alaska native youths in a large California metropolitan area: a descriptive study. | 2012 | Community Ment Health J | pmid:21161379 |