4-hydroxy-butyric acid

4-hydroxy-butyric acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 8613 references associated with 4-hydroxy-butyric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 4-hydroxy-butyric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-hydroxy-butyric acid

MeSH term MeSH ID Detail
Fever D005334 35 associated lipids
Catalepsy D002375 30 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Radiation Injuries, Experimental D011833 11 associated lipids
Shock, Traumatic D012774 4 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Tremor D014202 15 associated lipids
Parkinson Disease D010300 53 associated lipids
Per page 10 20 50 100 | Total 113

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 4-hydroxy-butyric acid

Download all related citations
Per page 10 20 50 100 | Total 3045
Authors Title Published Journal PubMed Link
El-Habr EA et al. A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma. 2017 Acta Neuropathol. pmid:28032215
Busardò FP et al. Assessment of the stability of exogenous gamma hydroxybutyric acid (GHB) in stored blood and urine specimens. 2015 Eur Rev Med Pharmacol Sci pmid:26592846
Kim M et al. Two pathways for glutamate biosynthesis in the syntrophic bacterium Syntrophus aciditrophicus. 2015 Appl. Environ. Microbiol. pmid:26431966
Dave RA and Morris ME Semi-mechanistic kidney model incorporating physiologically-relevant fluid reabsorption and transporter-mediated renal reabsorption: pharmacokinetics of γ-hydroxybutyric acid and L-lactate in rats. 2015 J Pharmacokinet Pharmacodyn pmid:26341876
Bosch OG et al. Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone. 2015 Psychoneuroendocrinology pmid:26209926
Kawase T et al. Novel fluorinated gemini surfactants with γ-butyrolactone segments. 2015 J Oleo Sci pmid:25748377
Otte J et al. Malonic semialdehyde reductase from the archaeon Nitrosopumilus maritimus is involved in the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle. 2015 Appl. Environ. Microbiol. pmid:25548047
Luca G et al. Central and peripheral metabolic changes induced by gamma-hydroxybutyrate. 2015 Sleep pmid:25515097
Claussen MC et al. Catatonic stupor secondary to gamma-hydroxy-butyric acid (GHB)-dependence and -withdrawal syndrome. 2014 Psychiatr Danub pmid:25377371
Gould T et al. GABA(B) receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid. 2014 Philos. Trans. R. Soc. Lond., B, Biol. Sci. pmid:25225100
Vijay N and Morris ME Effect of 3,4-methylenedioxymethamphetamine on the toxicokinetics and sedative effects of the drug of abuse, γ-hydroxybutyric acid. 2014 J Pharm Sci pmid:25174723
Cheung J et al. γ-Hydroxybutyric acid-induced electrographic seizures. 2014 J Clin Sleep Med pmid:25024661
Wendt G et al. Gamma-hydroxybutyrate, acting through an anti-apoptotic mechanism, protects native and amyloid-precursor-protein-transfected neuroblastoma cells against oxidative stress-induced death. 2014 Neuroscience pmid:24456637
Zhai D et al. Development of a fluorescent sensor for illicit date rape drug GHB. 2014 Chem. Commun. (Camb.) pmid:24492471
Kamal RM et al. Decision rules for GHB (γ-hydroxybutyric acid) detoxification: a vignette study. 2014 Drug Alcohol Depend pmid:24380737
Krishnamurthy VB et al. An interesting case of late age at onset of narcolepsy with cataplexy. 2014 J Clin Sleep Med pmid:24533004
Korf DJ et al. Risk factors of γ-hydroxybutyrate overdosing. 2014 Eur Addict Res pmid:24080792
Stomberg MW et al. Symptoms and signs in interpreting gamma-hydroxybutyrate (GHB) intoxication - an explorative study. 2014 Scand J Trauma Resusc Emerg Med pmid:24758357
Black SW et al. GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy. 2014 J. Neurosci. pmid:24806675
Yiu CY et al. Inhibition of Epstein-Barr virus lytic cycle by an ethyl acetate subfraction separated from Polygonum cuspidatum root and its major component, emodin. 2014 Molecules pmid:24448066
Eghorn LF et al. Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin. 2014 Eur. J. Pharmacol. pmid:24973695
Goodwin AK et al. Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons. 2013 Psychopharmacology (Berl.) pmid:22945514
Johnson MW and Griffiths RR Comparative abuse liability of GHB and ethanol in humans. 2013 Exp Clin Psychopharmacol pmid:23421353
Petersen IN et al. Identification of a new metabolite of GHB: gamma-hydroxybutyric acid glucuronide. 2013 J Anal Toxicol pmid:23612681
Ingels AS et al. Determination of gamma-hydroxybutyric acid in biofluids using a one-step procedure with "in-vial" derivatization and headspace-trap gas chromatography-mass spectrometry. 2013 J Chromatogr A pmid:23664352
Rosi L et al. Determination of GHB and its precursors (GBL and 1,4-BD) in dietary supplements through the synthesis of their isotopologues and analysis by GC-MS method. 2013 J Pharm Biomed Anal pmid:23245230
Hawkins AS et al. Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea. 2013 J. Biol. Chem. pmid:23258541
Munshi T et al. Monitoring of the interconversion of gamma-butyrolactone (GBL) to gamma hydroxybutyric acid (GHB) by Raman spectroscopy. 2013 Drug Test Anal pmid:23225646
Amer B et al. Novel GHB-derived natural products from European mistletoe (Viscum album). 2013 Pharm Biol pmid:23734579
de Jong CA et al. Treatment of GHB withdrawal syndrome: Catch 22 or challenge for addiction medicine? 2013 Addiction pmid:23718746
Choi S et al. Production of 4-hydroxybutyric acid by metabolically engineered Mannheimia succiniciproducens and its conversion to γ-butyrolactone by acid treatment. 2013 Metab. Eng. pmid:24055777
Liu X et al. The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes. 2013 Neuropharmacology pmid:23665355
Forni S et al. Quantitation of gamma-hydroxybutyric acid in dried blood spots: feasibility assessment for newborn screening of succinic semialdehyde dehydrogenase (SSADH) deficiency. 2013 Mol. Genet. Metab. pmid:23742746
Hermann-Krauss C et al. Archaeal production of polyhydroxyalkanoate (PHA) co- and terpolyesters from biodiesel industry-derived by-products. 2013 Archaea pmid:24453697
Vogensen SB et al. New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites. 2013 J. Med. Chem. pmid:24053696
Spaeth M et al. Long-term tolerability and maintenance of therapeutic response to sodium oxybate in an open-label extension study in patients with fibromyalgia. 2013 Arthritis Res. Ther. pmid:24286114
Fordahl S et al. Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors. 2012 Jan-Feb Neurotoxicol Teratol pmid:22056924
Wong J et al. Linking oviposition site choice to offspring fitness in Aedes aegypti: consequences for targeted larval control of dengue vectors. 2012 PLoS Negl Trop Dis pmid:22563512
Morse BL et al. γ-Hydroxybutyrate (GHB)-induced respiratory depression: combined receptor-transporter inhibition therapy for treatment in GHB overdose. 2012 Mol. Pharmacol. pmid:22561075
Lecendreux M et al. Tolerance and efficacy of sodium oxybate in childhood narcolepsy with cataplexy: a retrospective study. 2012 Sleep pmid:22547897
Da Ines O et al. Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana. 2012 PLoS Genet. pmid:22532804
Yan X et al. Functional identification and characterization of the Brassica napus transcription factor gene BnAP2, the ortholog of Arabidopsis thaliana APETALA2. 2012 PLoS ONE pmid:22479468
Ulmer A et al. Dihydrocodeine/Agonists for alcohol dependents. 2012 Front Psychiatry pmid:22470353
Lund C et al. Outpatient treatment of acute poisonings in Oslo: poisoning pattern, factors associated with hospitalization, and mortality. 2012 Scand J Trauma Resusc Emerg Med pmid:22217253
Guo YP et al. Nuclear and plastid haplotypes suggest rapid diploid and polyploid speciation in the N Hemisphere Achillea millefolium complex (Asteraceae). 2012 BMC Evol. Biol. pmid:22214230
Medvecky L Microstructure and properties of polyhydroxybutyrate-chitosan-nanohydroxyapatite composite scaffolds. 2012 ScientificWorldJournal pmid:22547987
Stein LA et al. Preliminary web-based measures development for GHB: expectancies, functions, and withdrawal. 2012 Am J Drug Alcohol Abuse pmid:22175869
Macieira S et al. Crystal structure of the complex between 4-hydroxybutyrate CoA-transferase from Clostridium aminobutyricum and CoA. 2012 Arch. Microbiol. pmid:21833509
Zeitzer JM et al. Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey. 2012 J Sleep Res pmid:21910776
Mao C et al. The effect of folic acid on ovine fetuses in utero during late gestation. 2012 Drug Chem Toxicol pmid:21848402