4-hydroxy-butyric acid

4-hydroxy-butyric acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 8613 references associated with 4-hydroxy-butyric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 4-hydroxy-butyric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-hydroxy-butyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Per page 10 20 50 100 | Total 113

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 4-hydroxy-butyric acid

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Per page 10 20 50 100 | Total 3045
Authors Title Published Journal PubMed Link
Kamal RM et al. Decision rules for GHB (γ-hydroxybutyric acid) detoxification: a vignette study. 2014 Drug Alcohol Depend pmid:24380737
Goodwin AK et al. Self-administration of gamma-hydroxybutyric acid (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons. 2013 Psychopharmacology (Berl.) pmid:22945514
Johnson MW and Griffiths RR Comparative abuse liability of GHB and ethanol in humans. 2013 Exp Clin Psychopharmacol pmid:23421353
Petersen IN et al. Identification of a new metabolite of GHB: gamma-hydroxybutyric acid glucuronide. 2013 J Anal Toxicol pmid:23612681
Ingels AS et al. Determination of gamma-hydroxybutyric acid in biofluids using a one-step procedure with "in-vial" derivatization and headspace-trap gas chromatography-mass spectrometry. 2013 J Chromatogr A pmid:23664352
Rosi L et al. Determination of GHB and its precursors (GBL and 1,4-BD) in dietary supplements through the synthesis of their isotopologues and analysis by GC-MS method. 2013 J Pharm Biomed Anal pmid:23245230
Hawkins AS et al. Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea. 2013 J. Biol. Chem. pmid:23258541
Munshi T et al. Monitoring of the interconversion of gamma-butyrolactone (GBL) to gamma hydroxybutyric acid (GHB) by Raman spectroscopy. 2013 Drug Test Anal pmid:23225646
Amer B et al. Novel GHB-derived natural products from European mistletoe (Viscum album). 2013 Pharm Biol pmid:23734579
de Jong CA et al. Treatment of GHB withdrawal syndrome: Catch 22 or challenge for addiction medicine? 2013 Addiction pmid:23718746
Choi S et al. Production of 4-hydroxybutyric acid by metabolically engineered Mannheimia succiniciproducens and its conversion to γ-butyrolactone by acid treatment. 2013 Metab. Eng. pmid:24055777
Liu X et al. The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes. 2013 Neuropharmacology pmid:23665355
Forni S et al. Quantitation of gamma-hydroxybutyric acid in dried blood spots: feasibility assessment for newborn screening of succinic semialdehyde dehydrogenase (SSADH) deficiency. 2013 Mol. Genet. Metab. pmid:23742746
Hermann-Krauss C et al. Archaeal production of polyhydroxyalkanoate (PHA) co- and terpolyesters from biodiesel industry-derived by-products. 2013 Archaea pmid:24453697
Vogensen SB et al. New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites. 2013 J. Med. Chem. pmid:24053696
Spaeth M et al. Long-term tolerability and maintenance of therapeutic response to sodium oxybate in an open-label extension study in patients with fibromyalgia. 2013 Arthritis Res. Ther. pmid:24286114
Fordahl S et al. Waterborne manganese exposure alters plasma, brain, and liver metabolites accompanied by changes in stereotypic behaviors. 2012 Jan-Feb Neurotoxicol Teratol pmid:22056924
Roiko SA et al. Brain uptake of the drug of abuse γ-hydroxybutyric acid in rats. 2012 Drug Metab. Dispos. pmid:22019629
Buddhala C et al. Calpain cleavage of brain glutamic acid decarboxylase 65 is pathological and impairs GABA neurotransmission. 2012 PLoS ONE pmid:22427928
Boomershine CS A comprehensive evaluation of standardized assessment tools in the diagnosis of fibromyalgia and in the assessment of fibromyalgia severity. 2012 Pain Res Treat pmid:22110942