4-hydroxy-butyric acid

4-hydroxy-butyric acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 8613 references associated with 4-hydroxy-butyric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 4-hydroxy-butyric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-hydroxy-butyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Per page 10 20 50 100 | Total 113

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 4-hydroxy-butyric acid

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Per page 10 20 50 100 | Total 3045
Authors Title Published Journal PubMed Link
Mignot EJ A practical guide to the therapy of narcolepsy and hypersomnia syndromes. 2012 Neurotherapeutics pmid:23065655
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Alshaikh MK et al. Sodium oxybate for narcolepsy with cataplexy: systematic review and meta-analysis. 2012 J Clin Sleep Med pmid:22893778
Lau NS and Sudesh K Revelation of the ability of Burkholderia sp. USM (JCM 15050) PHA synthase to polymerize 4-hydroxybutyrate monomer. 2012 AMB Express pmid:22877240
Vienne J et al. Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory. 2012 Sleep pmid:22851803
Goodson SG et al. Metabolic substrates exhibit differential effects on functional parameters of mouse sperm capacitation. 2012 Biol. Reprod. pmid:22837480
Roll JM et al. Preference for gamma-hydroxybutyrate (GHB) in current users. 2012 J Exp Anal Behav pmid:22693361
Kornhauser A et al. Effects of cosmetic formulations containing hydroxyacids on sun-exposed skin: current applications and future developments. 2012 Dermatol Res Pract pmid:22675344
McElroy SL et al. Pharmacological management of binge eating disorder: current and emerging treatment options. 2012 Ther Clin Risk Manag pmid:22654518
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Baglioni S et al. Functional differences in visceral and subcutaneous fat pads originate from differences in the adipose stem cell. 2012 PLoS ONE pmid:22574183
Wong J et al. Linking oviposition site choice to offspring fitness in Aedes aegypti: consequences for targeted larval control of dengue vectors. 2012 PLoS Negl Trop Dis pmid:22563512
Grenier V et al. Enzymatic assay for GHB determination in forensic matrices. 2012 J Anal Toxicol pmid:22722059
Dematteis M et al. [Current knowledge on gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL) and 1 ,4-butanediol (1,4-BD)]. 2012 Rev Prat pmid:22730800
Absalom N et al. α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22753476
van Amsterdam JG et al. Risk assessment of gamma-hydroxybutyric acid (GHB) in the Netherlands. 2012 Regul. Toxicol. Pharmacol. pmid:22440552
Zhou Q et al. [Application of high efficiency promoters in microbial production of 4-hydroxybutyric acid]. 2012 Sheng Wu Gong Cheng Xue Bao pmid:22667108
Sałat K et al. Analgesic and anticonvulsant activity of new derivatives of 2-substituted 4-hydroxybutanamides in mice. 2012 Pharmacol Rep pmid:22580526
Van Havere T et al. Illicit drug use in the flemish nightlife scene between 2003 and 2009. 2012 Eur Addict Res pmid:22398749
Enna SJ Extrasynaptic site of action for γ-hydroxybutyrate. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22851768
Hertz L Metabolic studies in brain slices - past, present, and future. 2012 Front Pharmacol pmid:22408619
Cao S et al. A mitochondria-dependent pathway mediates the apoptosis of GSE-induced yeast. 2012 PLoS ONE pmid:22403727
Fujii M et al. Acquisition of aluminium tolerance by modification of a single gene in barley. 2012 Nat Commun pmid:22395604
van Amsterdam JG et al. [Cognitive impairment due to intensive use and overdoses of gammahydroxybutyric acid (GHB)]. 2012 Tijdschr Psychiatr pmid:23250641
Allegrini G et al. Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers. 2012 Angiogenesis pmid:22382585
Robert Valeri C and Veech RL The unrecognized effects of the volume and composition of the resuscitation fluid used during the administration of blood products. 2012 Transfus. Apher. Sci. pmid:22364841
Wu J et al. Transcriptional repressor NIR functions in the ribosome RNA processing of both 40S and 60S subunits. 2012 PLoS ONE pmid:22363708
Aromatario M et al. New "lethal highs": a case of a deadly cocktail of GHB and Mephedrone. 2012 Forensic Sci. Int. pmid:23088826
Roelfsema F et al. Prolactin secretion in healthy adults is determined by gender, age and body mass index. 2012 PLoS ONE pmid:22363612
Loche A et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. 2012 Front Psychiatry pmid:22347868
Kong LA et al. Different chitin synthase genes are required for various developmental and plant infection processes in the rice blast fungus Magnaporthe oryzae. 2012 PLoS Pathog. pmid:22346755
Ogata Y et al. ECOMICS: a web-based toolkit for investigating the biomolecular web in ecosystems using a trans-omics approach. 2012 PLoS ONE pmid:22319563
Koek W et al. Effects of the GABAB receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons. 2012 J. Pharmacol. Exp. Ther. pmid:22319197
Boyd JJ et al. Temporal differences in γ-hydroxybutyrate overdoses involving injecting drug users versus recreational drug users in Helsinki: a retrospective study. 2012 Scand J Trauma Resusc Emerg Med pmid:22296777
Spaeth M et al. Sodium oxybate therapy provides multidimensional improvement in fibromyalgia: results of an international phase 3 trial. 2012 Ann. Rheum. Dis. pmid:22294641
Lang C et al. Impaired chromatin remodelling at STAT1-regulated promoters leads to global unresponsiveness of Toxoplasma gondii-infected macrophages to IFN-γ. 2012 PLoS Pathog. pmid:22275866
Liu Z et al. The cysteine rich necrotrophic effector SnTox1 produced by Stagonospora nodorum triggers susceptibility of wheat lines harboring Snn1. 2012 PLoS Pathog. pmid:22241993
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Saadeh M et al. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. 2012 PLoS ONE pmid:22272304
Krueger T and Melendez P Effect of ghrelin on feed intake and metabolites in lambs. 2012 Appetite pmid:22280977
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Bosch OG et al. Reconsidering GHB: orphan drug or new model antidepressant? 2012 J. Psychopharmacol. (Oxford) pmid:21926421
Marinetti LJ et al. Gamma butyrolactone (GBL) and gamma valerolactone (GVL): similarities and differences in their effects on the acoustic startle reflex and the conditioned enhancement of startle in the rat. 2012 Pharmacol. Biochem. Behav. pmid:22349589
Macieira S et al. Crystal structure of the complex between 4-hydroxybutyrate CoA-transferase from Clostridium aminobutyricum and CoA. 2012 Arch. Microbiol. pmid:21833509
Dickerson DL and Johnson CL Mental health and substance abuse characteristics among a clinical sample of urban American Indian/Alaska native youths in a large California metropolitan area: a descriptive study. 2012 Community Ment Health J pmid:21161379
Wanders RJ et al. Enzymology of the branched-chain amino acid oxidation disorders: the valine pathway. 2012 J. Inherit. Metab. Dis. pmid:21104317
Mao C et al. The effect of folic acid on ovine fetuses in utero during late gestation. 2012 Drug Chem Toxicol pmid:21848402