4-hydroxy-butyric acid

4-hydroxy-butyric acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 8613 references associated with 4-hydroxy-butyric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for 4-hydroxy-butyric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-hydroxy-butyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Per page 10 20 50 100 | Total 113

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 4-hydroxy-butyric acid

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Authors Title Published Journal PubMed Link
Elian AA and Hackett J Anion exchange SPE and liquid chromatography-tandem mass spectrometry in GHB analysis. 2011 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:22055831
Ingels AS et al. Dried blood spot punches for confirmation of suspected γ-hydroxybutyric acid intoxications: validation of an optimized GC-MS procedure. 2011 Bioanalysis pmid:22011175
Thondorf I et al. Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1). 2011 Bioorg. Med. Chem. pmid:21955456
Zhou Q et al. Production of 3-hydroxypropionate homopolymer and poly(3-hydroxypropionate-co-4-hydroxybutyrate) copolymer by recombinant Escherichia coli. 2011 Metab. Eng. pmid:22024131
Hartley S et al. Sodium oxybate and sleep apnea: a clinical case. 2011 J Clin Sleep Med pmid:22171208
Langford J and Gross WL Psychosis in the context of sodium oxybate therapy. 2011 J Clin Sleep Med pmid:22171207
Vindrieux D et al. Down-regulation of DcR2 sensitizes androgen-dependent prostate cancer LNCaP cells to TRAIL-induced apoptosis. 2011 Cancer Cell Int. pmid:22136382
Aryal UK et al. Dynamic proteomic profiling of a unicellular cyanobacterium Cyanothece ATCC51142 across light-dark diurnal cycles. 2011 BMC Syst Biol pmid:22133144
Davis MM et al. Wild-type Drosophila melanogaster as a model host to analyze nitrogen source dependent virulence of Candida albicans. 2011 PLoS ONE pmid:22110651
Bowen MT et al. Adolescent oxytocin exposure causes persistent reductions in anxiety and alcohol consumption and enhances sociability in rats. 2011 PLoS ONE pmid:22110618
Kogoj D et al. Alpe adria report 2010 - conclusions and recommendations for the treatment of alcohol dependence. 2011 Front Psychiatry pmid:22065959
Rice MW et al. Neurochemical characterization of the tree shrew dorsal striatum. 2011 Front Neuroanat pmid:21887131
Sircar R et al. GHB-Induced Cognitive Deficits During Adolescence and the Role of NMDA Receptor. 2011 Curr Neuropharmacol pmid:21886597
Binienda ZK et al. Analysis of electrical brain waves in neurotoxicology: γ-hydroxybutyrate. 2011 Curr Neuropharmacol pmid:21886596
Chao Y and Zhang T Optimization of fixation methods for observation of bacterial cell morphology and surface ultrastructures by atomic force microscopy. 2011 Appl. Microbiol. Biotechnol. pmid:21881891
Yoshida K et al. B chromosomes have a functional effect on female sex determination in Lake Victoria cichlid fishes. 2011 PLoS Genet. pmid:21876673
Peng CH et al. A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma. 2011 PLoS ONE pmid:21853135
Francis L et al. Controlled delivery of gentamicin using poly(3-hydroxybutyrate) microspheres. 2011 Int J Mol Sci pmid:21845079
Asad M et al. 2-[(E)-(2,4-Dichloro-benzyl-idene)amino]-isoindoline-1,3-dione. 2011 Acta Crystallogr Sect E Struct Rep Online pmid:21837105
Mendes AA et al. Immobilization of a Commercial Lipase from Penicillium camembertii (Lipase G) by Different Strategies. 2011 Enzyme Res pmid:21811674
Villela Filho M et al. Chemistry based on renewable raw materials: perspectives for a sugar cane-based biorefinery. 2011 Enzyme Res pmid:21637329
He JH et al. Allelic interaction of F1 pollen sterility loci and abnormal chromosome behaviour caused pollen sterility in intersubspecific autotetraploid rice hybrids. 2011 J. Exp. Bot. pmid:21624978
Park A and Stacy M Dopamine-induced nonmotor symptoms of Parkinson's disease. 2011 Parkinsons Dis pmid:21603184
Hunziker L et al. Rac1 deletion causes thymic atrophy. 2011 PLoS ONE pmid:21559396
Huang K et al. HYR1-mediated detoxification of reactive oxygen species is required for full virulence in the rice blast fungus. 2011 PLoS Pathog. pmid:21533213
El-Ansary AK et al. Plasma fatty acids as diagnostic markers in autistic patients from Saudi Arabia. 2011 Lipids Health Dis pmid:21510882
White H and Venkatesh B Clinical review: ketones and brain injury. 2011 Crit Care pmid:21489321
Chen X et al. Three homologous genes encoding sn-glycerol-3-phosphate acyltransferase 4 exhibit different expression patterns and functional divergence in Brassica napus. 2011 Plant Physiol. pmid:21173024
Engstrom EM et al. Arabidopsis homologs of the petunia hairy meristem gene are required for maintenance of shoot and root indeterminacy. 2011 Plant Physiol. pmid:21173022
Oleszczuk S et al. Aneuploidy among androgenic progeny of hexaploid triticale (XTriticosecale Wittmack). 2011 Plant Cell Rep. pmid:21170716
Ellison CT et al. XAP5 CIRCADIAN TIMEKEEPER regulates ethylene responses in aerial tissues of Arabidopsis. 2011 Plant Physiol. pmid:21163961
Löbler M et al. Polymers and drugs suitable for the development of a drug delivery drainage system in glaucoma surgery. 2011 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:21432996
Hasan L et al. An enzymatic method to determine γ-hydroxybutyric acid in serum and urine. 2011 Ther Drug Monit pmid:22105594
Lesar CT et al. Report on the analysis of common beverages spiked with gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) using NMR and the PURGE solvent-suppression technique. 2011 Forensic Sci. Int. pmid:21775083
Maremmani AG et al. Long-term γ-hydroxybutyric acid (GHB) and disulfiram combination therapy in GHB treatment-resistant chronic alcoholics. 2011 Int J Environ Res Public Health pmid:21845160
George CF et al. A 2-week, polysomnographic, safety study of sodium oxybate in obstructive sleep apnea syndrome. 2011 Sleep Breath pmid:20082240
Spitzer AR and Broadman M Treatment of the narcoleptiform sleep disorder in chronic fatigue syndrome and fibromyalgia with sodium oxybate. 2010 Jan-Feb Pain Pract pmid:20629967
Singh H et al. Antidepressant/anxiolytic and anti-nociceptive effects of novel 2-substituted 1,4-benzodiazepine-2-ones. 2010 Apr-Jun Sci Pharm pmid:21179341
Baeza C et al. Comparative karyotypic analysis in the Alstroemeria hookeri Lodd. (Alstroemeriaceae) complex sensu Bayer (1987). 2010 Genet. Mol. Biol. pmid:21637614
Mehdi SH et al. 2,2,4-Trimethyl-7-nitro-2,3-dihydro-1H-1,5-benzodiazepin-5-ium perchlorate. 2010 Acta Crystallogr Sect E Struct Rep Online pmid:21588044
Mehdi SH et al. 1,3,3-Trimethyl-1,2,3,4-tetra-hydro-pyrido[1,2-a]benzimidazol-1-ol. 2010 Acta Crystallogr Sect E Struct Rep Online pmid:21588036
Oh SA et al. The tobacco MAP215/Dis1-family protein TMBP200 is required for the functional organization of microtubule arrays during male germline establishment. 2010 J. Exp. Bot. pmid:20022922
Lora J et al. The progamic phase of an early-divergent angiosperm, Annona cherimola (Annonaceae). 2010 Ann. Bot. pmid:19939980
Ramo DE et al. Typology of club drug use among young adults recruited using time-space sampling. 2010 Drug Alcohol Depend pmid:19939585
Caputo F and Bernardi M Medications acting on the GABA system in the treatment of alcoholic patients. 2010 Curr. Pharm. Des. pmid:20482512
Feldman NT Clinical perspective: monitoring sodium oxybate-treated narcolepsy patients for the development of sleep-disordered breathing. 2010 Sleep Breath pmid:19626356
Watson J et al. Gamma-hydroxybutyrate does not maintain self-administration but induces conditioned place preference when injected in the ventral tegmental area. 2010 Int. J. Neuropsychopharmacol. pmid:19573264
Kato O et al. Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate. 2010 BMC Microbiol. pmid:21159175
Ren Q et al. Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives. 2010 Appl. Microbiol. Biotechnol. pmid:20393709
Earley B et al. Effect of road transport for up to 24 hours followed by twenty-four hour recovery on live weight and physiological responses of bulls. 2010 BMC Vet. Res. pmid:20646269
Purrucker JC et al. HDAC inhibition radiosensitizes human normal tissue cells and reduces DNA Double-Strand Break repair capacity. 2010 Oncol. Rep. pmid:19956891
Ide T Enzymatic-HPLC method to analyze D-3-hydroxybutyric acid in rat serum. 2010 Biosci. Biotechnol. Biochem. pmid:20699574
Mountassif D et al. Structural and catalytic properties of the D-3-hydroxybutyrate dehydrogenase from Pseudomonas aeruginosa. 2010 Curr. Microbiol. pmid:20052585
Kirmse K et al. GABA depolarizes immature neocortical neurons in the presence of the ketone body ß-hydroxybutyrate. 2010 J. Neurosci. pmid:21106838
Lahnsteiner F et al. Composition and metabolism of carbohydrates and lipids in Sparus aurata semen and its relation to viability expressed as sperm motility when activated. 2010 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:20441800
García de María C and Hueso Domínguez KB Simultaneous kinetic determination of 3-hydroxybutyrate and 3-hydroxyvalerate in biopolymer degradation processes. 2010 Talanta pmid:20006110
Likić VA et al. Systems biology: the next frontier for bioinformatics. 2010 Adv Bioinformatics pmid:21331364
Merz H et al. Interleukin-9 (IL-9) and NPM-ALK each generate mast cell hyperplasia as single 'hit' and cooperate in producing a mastocytosis-like disease in mice. 2010 Oncotarget pmid:21297223
La Cono V et al. Genomic signatures of fifth autotrophic carbon assimilation pathway in bathypelagic Crenarchaeota. 2010 Microb Biotechnol pmid:21255356
Ingels AS et al. Determination of gamma-hydroxybutyric acid in dried blood spots using a simple GC-MS method with direct "on spot" derivatization. 2010 Anal Bioanal Chem pmid:20835862
Brown MT et al. Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. 2010 PLoS ONE pmid:21209835
Li S et al. Efficacy of manual jet ventilation using Manujet III for bronchoscopic airway foreign body removal in children. 2010 Int. J. Pediatr. Otorhinolaryngol. pmid:20951443
Sciotti MA et al. Development and characterization of an enzymatic method for the rapid determination of gamma hydroxybutyric acid. 2010 Chimia (Aarau) pmid:21197843
Peng Q et al. 1A6/DRIM, a novel t-UTP, activates RNA polymerase I transcription and promotes cell proliferation. 2010 PLoS ONE pmid:21151873
Pérez-García C et al. Chromosomal mapping of rRNA genes, core histone genes and telomeric sequences in Brachidontes puniceus and Brachidontes rodriguezi (Bivalvia, Mytilidae). 2010 BMC Genet. pmid:21143946
Skovran E et al. A systems biology approach uncovers cellular strategies used by Methylobacterium extorquens AM1 during the switch from multi- to single-carbon growth. 2010 PLoS ONE pmid:21124828
Mandáková T et al. Island species radiation and karyotypic stasis in Pachycladon allopolyploids. 2010 BMC Evol. Biol. pmid:21114825
Aran A et al. Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children. 2010 Sleep pmid:21102987
Victório SC et al. Absence of IFNγ expression induces neuronal degeneration in the spinal cord of adult mice. 2010 J Neuroinflammation pmid:21073708
Li H et al. Production of gamma-aminobutyric acid by Lactobacillus brevis NCL912 using fed-batch fermentation. 2010 Microb. Cell Fact. pmid:21070676
Pichini S et al. Immunomodulating properties of gamma-hydroxybutyrate (GHB), flunitrazepam and ethanol in 'club drugs' users. 2010 Addict Biol pmid:20456291
Berg IA et al. Study of the distribution of autotrophic CO2 fixation cycles in Crenarchaeota. 2010 Microbiology (Reading, Engl.) pmid:19850614
Escalera GI et al. [Succinic semialdehyde dehydrogenase deficiency: decrease in 4-OH-butyric acid levels with low doses of vigabatrin]. 2010 An Pediatr (Barc) pmid:20018576
Lam WK et al. Monocarboxylate transporter-mediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells. 2010 Drug Metab. Dispos. pmid:19952290
Janssen PJ et al. The complete genome sequence of Cupriavidus metallidurans strain CH34, a master survivalist in harsh and anthropogenic environments. 2010 PLoS ONE pmid:20463976
Yallapu MM et al. Scope of nanotechnology in ovarian cancer therapeutics. 2010 J Ovarian Res pmid:20691083
Young SA and Smith TK The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei. 2010 Mol. Microbiol. pmid:20398210
Moldofsky H et al. Effects of sodium oxybate on sleep physiology and sleep/wake-related symptoms in patients with fibromyalgia syndrome: a double-blind, randomized, placebo-controlled study. 2010 J. Rheumatol. pmid:20682669
Nasrallah FA et al. γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB. 2010 J. Neurochem. pmid:20681954
Ding SL et al. The tig1 histone deacetylase complex regulates infectious growth in the rice blast fungus Magnaporthe oryzae. 2010 Plant Cell pmid:20675574
Dew BJ Toward a Better Understanding of Non-Addicted, Methamphetamine-Using, Men who Have Sex with Men (MSM) in Atlanta. 2010 Open AIDS J pmid:20657718
Bjornaas MA et al. Suicidal intention, psychosocial factors and referral to further treatment: a one-year cross-sectional study of self-poisoning. 2010 BMC Psychiatry pmid:20653986
Mandáková T et al. Fast diploidization in close mesopolyploid relatives of Arabidopsis. 2010 Plant Cell pmid:20639445
Sadhukhan S et al. Using isotopic tools to dissect and quantitate parallel metabolic pathways. 2010 J. Am. Chem. Soc. pmid:20408520
Zeng W et al. A glucurono(arabino)xylan synthase complex from wheat contains members of the GT43, GT47, and GT75 families and functions cooperatively. 2010 Plant Physiol. pmid:20631319
Koek W et al. GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo. 2010 J. Pharmacol. Exp. Ther. pmid:20628000
Girish TS and Gopal B Crystal structure of Staphylococcus aureus metallopeptidase (Sapep) reveals large domain motions between the manganese-bound and apo-states. 2010 J. Biol. Chem. pmid:20610394
Morsy MD et al. A potential protective effect of alpha-tocopherol on vascular complication in spinal cord reperfusion injury in rats. 2010 J. Biomed. Sci. pmid:20609232
Exempt chemical mixtures containing gamma-butyrolactone. Final rule. 2010 Fed Regist pmid:20608286
Hirose T et al. Disruption of a gene for rice sucrose transporter, OsSUT1, impairs pollen function but pollen maturation is unaffected. 2010 J. Exp. Bot. pmid:20603282
Li H et al. Misexpression of miR482, miR1512, and miR1515 increases soybean nodulation. 2010 Plant Physiol. pmid:20508137
Yamamiya I et al. Formation pathways of gamma-butyrolactone from the furan ring of tegafur during its conversion to 5-fluorouracil. 2010 Drug Metab. Dispos. pmid:20463005
Arnoult N et al. Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization. 2010 PLoS Genet. pmid:20421929
Carland F et al. The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products. 2010 Plant Physiol. pmid:20421456
Cornille E et al. Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury. 2010 BMC Neurosci pmid:20416081
Covey PA et al. A pollen-specific RALF from tomato that regulates pollen tube elongation. 2010 Plant Physiol. pmid:20388667
Koo BS et al. Improvement of coenzyme Q(10) production by increasing the NADH/NAD(+) ratio in Agrobacterium tumefaciens. 2010 Biosci. Biotechnol. Biochem. pmid:20378960
Bortolato M et al. GABAB receptor activation exacerbates spontaneous spike-and-wave discharges in DBA/2J mice. 2010 Seizure pmid:20233662
Felmlee MA et al. Concentration-effect relationships for the drug of abuse gamma-hydroxybutyric acid. 2010 J. Pharmacol. Exp. Ther. pmid:20215411
Juarez E et al. Differential expression of Toll-like receptors on human alveolar macrophages and autologous peripheral monocytes. 2010 Respir. Res. pmid:20051129