4-hydroxy-butyric acid

4-hydroxy-butyric acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 8613 references associated with 4-hydroxy-butyric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 4-hydroxy-butyric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-hydroxy-butyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Per page 10 20 50 100 | Total 113

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 4-hydroxy-butyric acid

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Per page 10 20 50 100 | Total 3045
Authors Title Published Journal PubMed Link
Grenier V et al. Enzymatic assay for GHB determination in forensic matrices. 2012 J Anal Toxicol pmid:22722059
Dematteis M et al. [Current knowledge on gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL) and 1 ,4-butanediol (1,4-BD)]. 2012 Rev Prat pmid:22730800
Absalom N et al. α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22753476
Hewitt G et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. 2012 Nat Commun pmid:22426229
Hertz L Metabolic studies in brain slices - past, present, and future. 2012 Front Pharmacol pmid:22408619
Cao S et al. A mitochondria-dependent pathway mediates the apoptosis of GSE-induced yeast. 2012 PLoS ONE pmid:22403727
Fujii M et al. Acquisition of aluminium tolerance by modification of a single gene in barley. 2012 Nat Commun pmid:22395604
Dickerson DL and Johnson CL Mental health and substance abuse characteristics among a clinical sample of urban American Indian/Alaska native youths in a large California metropolitan area: a descriptive study. 2012 Community Ment Health J pmid:21161379
Guerreiro DF et al. [Club drugs]. 2011 Sep-Oct Acta Med Port pmid:22525626
Stein LA et al. A web-based study of gamma hydroxybutyrate (GHB): patterns, experiences, and functions of use. 2011 Jan-Feb Am J Addict pmid:21175918
Lane T et al. High HIV prevalence among men who have sex with men in Soweto, South Africa: results from the Soweto Men's Study. 2011 AIDS Behav pmid:19662523
Swick TJ Sodium oxybate: a potential new pharmacological option for the treatment of fibromyalgia syndrome. 2011 Ther Adv Musculoskelet Dis pmid:22870476
Zhang X and Chen G [Enzymes related with NAD synthesis promote conversion of 1,4-butanediol to 4-hydroxybutyrate]. 2011 Sheng Wu Gong Cheng Xue Bao pmid:22506415
Alzeer S and Ellis EM The role of aldehyde reductase AKR1A1 in the metabolism of γ-hydroxybutyrate in 1321N1 human astrocytoma cells. 2011 Chem. Biol. Interact. pmid:21276435
Bramness JG and Haugland S [Abuse of γ-hydroxybutyrate]. 2011 Tidsskr. Nor. Laegeforen. pmid:22048208
Arendt EK et al. Medical nutrition therapy: use of sourdough lactic acid bacteria as a cell factory for delivering functional biomolecules and food ingredients in gluten free bread. 2011 Microb. Cell Fact. pmid:21995616
Sharakhova MV et al. Imaginal discs--a new source of chromosomes for genome mapping of the yellow fever mosquito Aedes aegypti. 2011 PLoS Negl Trop Dis pmid:21991400
Kamberov YG et al. Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells. 2011 BMC Res Notes pmid:21974968
Molnár T et al. Calcium signals in the nucleus accumbens: activation of astrocytes by ATP and succinate. 2011 BMC Neurosci pmid:21967230
Payne CM et al. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. 2011 Clin Exp Gastroenterol pmid:21753893
Poli A et al. Synthesis, production, and biotechnological applications of exopolysaccharides and polyhydroxyalkanoates by archaea. 2011 Archaea pmid:22007151
Yelamanchili SV et al. Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism. 2011 Mol Neurodegener pmid:21777416
Li W and Liu M Distribution of 5-hydroxymethylcytosine in different human tissues. 2011 J Nucleic Acids pmid:21772996
Smith HS et al. Pharmacotherapy for fibromyalgia. 2011 Front Pharmacol pmid:21772818
Alves LI et al. Chromosome characterization and variability in some Iridaceae from Northeastern Brazil. 2011 Genet. Mol. Biol. pmid:21734827
de França Rocha M et al. Comparative cytogenetic analysis of two grasshopper species of the tribe Abracrini (Ommatolampinae, Acrididae). 2011 Genet. Mol. Biol. pmid:21734819
Schmidt M et al. Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial. 2011 Nutr Metab (Lond) pmid:21794124
Wei YH et al. Biodegradable and biocompatible biomaterial, polyhydroxybutyrate, produced by an indigenous Vibrio sp. BM-1 isolated from marine environment. 2011 Mar Drugs pmid:21731553
Utsumi Y et al. Functional diversity of isoamylase oligomers: the ISA1 homo-oligomer is essential for amylopectin biosynthesis in rice endosperm. 2011 Plant Physiol. pmid:21436381
Moldofsky H and Patcai J Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study. 2011 BMC Neurol pmid:21435231
Soo JK et al. Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression. 2011 Pigment Cell Melanoma Res pmid:21418545
Urquhart W et al. The cyclic nucleotide-gated channels AtCNGC11 and 12 are involved in multiple Ca²⁺-dependent physiological responses and act in a synergistic manner. 2011 J. Exp. Bot. pmid:21414958
De Paoli G et al. Endogenous γ-hydroxybutyric acid concentrations in saliva determined by gas chromatography-mass spectrometry. 2011 J Anal Toxicol pmid:21439150
Poryazova R et al. Sodium oxybate in narcolepsy with cataplexy: Zurich sleep center experience. 2011 Eur. Neurol. pmid:21389728
Meyer MR et al. A validated GC-MS procedure for fast, simple, and cost-effective quantification of glycols and GHB in human plasma and their identification in urine and plasma developed for emergency toxicology. 2011 Anal Bioanal Chem pmid:21336790
Pujalté I et al. Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells. 2011 Part Fibre Toxicol pmid:21371295
Andresen H et al. An overview of gamma-hydroxybutyric acid: pharmacodynamics, pharmacokinetics, toxic effects, addiction, analytical methods, and interpretation of results. 2011 Drug Test Anal pmid:21381220
Sanna E et al. Voluntary Ethanol Consumption Induced by Social Isolation Reverses the Increase of α(4)/δ GABA(A) Receptor Gene Expression and Function in the Hippocampus of C57BL/6J Mice. 2011 Front Neurosci pmid:21347217
Felmlee MA et al. Use of a local sensitivity analysis to inform study design based on a mechanistic toxicokinetic model for γ-hydroxybutyric acid. 2011 AAPS J pmid:21387146
Marclay F et al. Source inference of exogenous gamma-hydroxybutyric acid (GHB) administered to humans by means of carbon isotopic ratio analysis: novel perspectives regarding forensic investigation and intelligence issues. 2011 Anal Bioanal Chem pmid:21455654
Ando Y et al. Two-step cleavage of hairpin RNA with 5' overhangs by human DICER. 2011 BMC Mol. Biol. pmid:21306637
Cagnin A et al. γ-Hydroxybutyric acid-induced psychosis and seizures. 2011 Epilepsy Behav pmid:21530412
Lenz D et al. Inhibition of 1,4-butanediol metabolism in human liver in vitro. 2011 Naunyn Schmiedebergs Arch. Pharmacol. pmid:21533996
Wamelink MM et al. 4-Hydroxybutyric aciduria associated with catheter usage: a diagnostic pitfall in the identification of SSADH deficiency. 2011 Mol. Genet. Metab. pmid:20965758
Kim KJ et al. Succinic semialdehyde dehydrogenase: biochemical-molecular-clinical disease mechanisms, redox regulation, and functional significance. 2011 Antioxid. Redox Signal. pmid:20973619
Shah TD et al. The characterization of a unique Trypanosoma brucei β-hydroxybutyrate dehydrogenase. 2011 Mol. Biochem. Parasitol. pmid:21767577
Maurer GD et al. Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. 2011 BMC Cancer pmid:21791085
Donjacour CE et al. Sodium oxybate increases prolactin secretion in narcolepsy patients and healthy controls. 2011 Eur. J. Endocrinol. pmid:21148631
Juchimiuk-Kwasniewska J et al. FISH in analysis of gamma ray-induced micronuclei formation in barley. 2011 J. Appl. Genet. pmid:21136232
Goodwin AK et al. Intravenous self-administration of γ-hydroxybutyrate (GHB) in baboons. 2011 Drug Alcohol Depend pmid:21112162