4-hydroxy-butyric acid

4-hydroxy-butyric acid is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 8613 references associated with 4-hydroxy-butyric acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 4-hydroxy-butyric acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 4-hydroxy-butyric acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Per page 10 20 50 100 | Total 113

PubChem Associated disorders and diseases

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with 4-hydroxy-butyric acid

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Per page 10 20 50 100 | Total 3045
Authors Title Published Journal PubMed Link
Lee CR Evidence for the beta-oxidation of orally administered 4-hydroxybutyrate in humans. 1977 Biochem Med pmid:869940
Hori M et al. A method for the estimation of peak serum LDH activity based on a single post-peak level after acute myocardial infarction. 1977 Jpn Heart J pmid:870728
KochubeÄ­ NM [Histochemical and morphometric changes in the adrenal cortex under conditions of acute vascular insufficiency]. 1977 Biull Eksp Biol Med pmid:884274
Kurilin AP [Microspectrophotometric characteristics of renal enzymes under conditions of acute vascular insufficiency]. 1977 Biull Eksp Biol Med pmid:884275
Vidal JC et al. Purification of apo-3-D-(-) hydroxybutyrate dehydrogenase from rat liver mitochondria. 1977 Mol. Cell. Biochem. pmid:887087
Taylor JR Massive creatine phosphokinase elevation with acute psychosis. 1977 Biol. Psychiatry pmid:889988
Barron KD et al. Quantitative cytochemistry of RNA in axotomized feline rubral neurons. 1977 Brain Res. pmid:890445
Miraglia T et al. Histochemical studies on the adrenal glands of the marmosets (Callithrix jacchus and Callithrix penicillata). 1976 Acta Anat (Basel) pmid:8944
Papa B et al. [The relationship between enzymatic changes and the clinical picture of acute myocardial infarction (author's transl)]. 1977 Lijec Vjesn pmid:895333
Pasquinucci C and Pittino R [Enzymatic and biochemical parameters in the diagnosis of malignant ovarian neoplasms]. 1977 Minerva Ginecol pmid:896086
Rabow L and Tibbling G Serum activities of hydroxybutyrate dehydrogenase (HBD) and the isoenzymes of lactate dehydrogenase (LD) as an index of traumatic brain injury. 1977 Acta Neurochir (Wien) pmid:906904
Ragan CI The interaction of reduced nicotinamide--adenine dinucleotide phosphate with reduced nicotinamide--adenine dinucleotide--ubiquinone reductase from bovine heart mitochondria. 1976 Biochem. J. pmid:9075
Chéramy A et al. Stimulating effects of gamma-hydroxybutyrate on dopamine release from the caudate nucleus and the substantia nigra of the cat. 1977 J. Pharmacol. Exp. Ther. pmid:909063
PertsovskiÄ­ AL and BalakleevskiÄ­ AI [Distribution of gamma-hydroxybutyric acid in different portions of the brain and in the serum of rats during anesthesia]. 1977 Biull Eksp Biol Med pmid:912056
Maas AI Cerebrospinal fluid enzymes in acute brain injury. 1. Dynamics of changes in CSF enzyme activity after acute experimental brain injury. 1977 J. Neurol. Neurosurg. Psychiatr. pmid:915509
Maas AI Cerebrospinal fluid enzymes in acute brain injury. 2. Relation of CSF enzyme activity to extent of brain injury. 1977 J. Neurol. Neurosurg. Psychiatr. pmid:915510
Vidal JC et al. 3-D-(-) Hydroxybutyrate dehydrogenase from rat liver mitochondria--purification and interaction with phospholipids. 1977 Adv. Exp. Med. Biol. pmid:920458
Krafft J et al. Serum enzymes and isoenzymes after surgery. 1977 Ann. Clin. Biochem. pmid:921211
Roth RH and Nowycky MC Dopaminergic neurons: effects elicited by gamma-hydroxybutyrate are reversed by picrotoxin. 1977 Biochem. Pharmacol. pmid:921818
Rumigny JF et al. Evidence that a specific succinic semialdehyde reductase is responsible for gamma-hydroxybutyrate synthesis in brain tissue slices. 1981 FEBS Lett. pmid:9222333
Beyer TV et al. [Cytochemical study of various stages of the life cycle of Toxoplasma gondii. 4. Dehydrogenases in the endozoa]. 1977 Tsitologiia pmid:929690
Lettieri J and Fung HL Absorption and first-pass metabolism of 14C-gamma-hydroxybutyric acid. 1976 Res. Commun. Chem. Pathol. Pharmacol. pmid:935634
Snead OC et al. Gamma hydroxybutyrate. Correlation of serum and cerebrospinal fluid levels with electroencephalographic and behavioral effects. 1976 Neurology pmid:942770
Burov IuV et al. [The tranquilizing properties of sodium hydroxybutyrate]. 1976 Biull Eksp Biol Med pmid:945087
Möhler H et al. Gamma-hydroxybutyrate degradation in the brain in vivo: negligible direct conversion to GABA. 1976 J. Neurochem. pmid:956829
Tabakoff B and Radulovacki M Gamma-hydroxybutyrate in CSF during sleep and wakefulness. 1976 Res. Commun. Chem. Pathol. Pharmacol. pmid:959660
Tuszkiewicz-Misztal E et al. [Lactic dehydrogenase and alpha-hydroxybutyric dehydrogenase activity in children with juvenile diabetes]. 1976 Pediatr Pol pmid:967594
Chambliss KL et al. Two exon-skipping mutations as the molecular basis of succinic semialdehyde dehydrogenase deficiency (4-hydroxybutyric aciduria). 1998 Am. J. Hum. Genet. pmid:9683595
Sudesh K et al. Genetic analysis of Comamonas acidovorans polyhydroxyalkanoate synthase and factors affecting the incorporation of 4-hydroxybutyrate monomer. 1998 Appl. Environ. Microbiol. pmid:9726894
Snead OC Gamma hydroxybutyrate in the monkey. I. Electroencephalographic, behavioral, and pharmacokinetic studies. 1978 Neurology pmid:97574
Snead OC Gamma hydroxybutyrate in the monkey. II. Effect of chronic oral anticonvulsant drugs. 1978 Neurology pmid:97575
Taberner PV The anticonvulsant activity of ketamine agains siezures induced by pentylenetetrazol and mercaptopropionic acid. 1976 Eur. J. Pharmacol. pmid:976326
Tunnicliff G Centrally-acting drugs and the formation of brain gamma-aminobutyric acid. 1976 Gen. Pharmacol. pmid:976740
Berg G et al. [Fasting values of carbohydrate--and lipid metabolism in healthy subjects and in patients with diabetes mellitus]. 1976 Fortschr. Med. pmid:976926
Snead OC Ganaxolone, a selective, high-affinity steroid modulator of the gamma-aminobutyric acid-A receptor, exacerbates seizures in animal models of absence. 1998 Ann. Neurol. pmid:9778270
Menon K et al. Pharmacological evidence for a selective antidopaminergic action of gamma-hydroxybutyric acid. 1976 J. Neural Transm. pmid:978199
Banerjee PK et al. Absence seizures decrease steroid modulation of t-[35S]butylbicyclophosphorothionate binding in thalamic relay nuclei. 1998 J. Pharmacol. Exp. Ther. pmid:9808708
Agabio R et al. Gamma-hydroxybutyric acid reducing effect on ethanol intake: evidence in favour of a substitution mechanism. 1998 Sep-Oct Alcohol Alcohol. pmid:9811198
Banerjee PK and Snead OC Neuroactive steroids exacerbate gamma-hydroxybutyric acid-induced absence seizures in rats. 1998 Eur. J. Pharmacol. pmid:9831291
Henderson RS and Holmes CM Reversal of the anaesthetic action of sodium gamma-hydroxybutyrate. 1976 Anaesth Intensive Care pmid:984396
Novitskaia AV [Activity of certain erythrocyte enzymes in hemolytic disease of the newborn]. 1976 Vopr Okhr Materin Det pmid:987642
Martellotta MC et al. Intravenous self-administration of gamma-hydroxybutyric acid in drug-naive mice. 1998 Eur Neuropsychopharmacol pmid:9928919
Cox RB and Quayle JR The growth of Pseudomonas AM1 on 4-hydroxybutyrate. 1976 J. Gen. Microbiol. pmid:993785
Da Prada M and Keller HH Baclofen and gamma-hydroxybutyrate: similar effects on cerebral dopamine neurones. 1976 Life Sci. pmid:994724
Isaev IuO [Use of sodium hydroxybutyrate for combined anesthesia in gynecologic surgery]. 1976 Sep-Oct Pediatr Akus Ginekol pmid:995491