1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Edema | D004487 | 152 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Potvin-Fournier K et al. | Membrane fluidity is a driving force for recoverin myristoyl immobilization in zwitterionic lipids. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28684313 |
| Heitz F and Spach G | Ionic channels of some glycine-rich synthetic polypeptides. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6284141 |
| Epand RM and Epand RF | Factors contributing to the fusogenic potency of foamy virus. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11409874 |
| Sindelar P and Valtersson C | A dolichol acyltransferase present in rat and human postheparin plasma. | 1992 | Biochem. Cell Biol. | pmid:1449712 |
| Chen SG et al. | Phosphatidylcholine-dependent protein kinase C activation. Effects of cis-fatty acid and diacylglycerol on synergism, autophosphorylation and Ca(2+)-dependency. | 1992 | Biochem. J. | pmid:1599399 |
| Sharpe M et al. | Fatty acids as modulators of cytochrome c oxidase in proteoliposomes. | 1996 | Biochem. J. | pmid:8973566 |
| Geisse NA et al. | Targeting of Helicobacter pylori vacuolating toxin to lipid raft membrane domains analysed by atomic force microscopy. | 2004 | Biochem. J. | pmid:15128269 |
| Tanfani F et al. | The interaction of phospholipid bilayers with pig heart AMP deaminase: Fourier-transform infrared spectroscopic and kinetic studies. | 1993 | Biochem. J. | pmid:8489518 |
| ter Beest MB et al. | Reconstitution of proteolipid protein: some properties and its role in interlamellar attachment. | 1994 | Biochem. J. | pmid:7516154 |
| Verkade HJ et al. | Differential hepatic processing and biliary secretion of head-group and acyl chains of liposomal phosphatidylcholines. | 1991 | Biochem. J. | pmid:2018469 |