1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sharmin S et al. | Effects of Lipid Composition on the Entry of Cell-Penetrating Peptide Oligoarginine into Single Vesicles. | 2016 | Biochemistry | pmid:27420912 |
| Niu SL et al. | Trans fatty acid derived phospholipids show increased membrane cholesterol and reduced receptor activation as compared to their cis analogs. | 2005 | Biochemistry | pmid:15766276 |
| Willems GM et al. | Competition of annexin V and anticardiolipin antibodies for binding to phosphatidylserine containing membranes. | 2000 | Biochemistry | pmid:10684648 |
| Islam MZ et al. | Entry of cell-penetrating peptide transportan 10 into a single vesicle by translocating across lipid membrane and its induced pores. | 2014 | Biochemistry | pmid:24397335 |
| Lee J and Lentz BR | Outer leaflet-packing defects promote poly(ethylene glycol)-mediated fusion of large unilamellar vesicles. | 1997 | Biochemistry | pmid:9003195 |
| Tatulian SA et al. | Uncovering a calcium-regulated membrane-binding mechanism for soybean lipoxygenase-1. | 1998 | Biochemistry | pmid:9799511 |
| Siminovitch DJ et al. | Effects of cis and trans unsaturation on the structure of phospholipid bilayers: a high-pressure infrared spectroscopic study. | 1987 | Biochemistry | pmid:3651382 |
| Buffy JJ et al. | Two-dimensional solid-state NMR reveals two topologies of sarcolipin in oriented lipid bilayers. | 2006 | Biochemistry | pmid:16953579 |
| Earnest JP et al. | Binding of local anesthetics to reconstituted acetylcholine receptors: effect of protein surface potential. | 1986 | Biochemistry | pmid:3022805 |
| Curran AR et al. | Modulation of folding and assembly of the membrane protein bacteriorhodopsin by intermolecular forces within the lipid bilayer. | 1999 | Biochemistry | pmid:10413507 |
| Willems GM et al. | Transient high affinity binding of tissue factor pathway inhibitor-factor Xa complexes to negatively charged phospholipid membranes. | 1998 | Biochemistry | pmid:9521652 |
| Lew S et al. | The effects of polar and/or ionizable residues in the core and flanking regions of hydrophobic helices on transmembrane conformation and oligomerization. | 2000 | Biochemistry | pmid:10933779 |
| Caputo GA and London E | Position and ionization state of Asp in the core of membrane-inserted alpha helices control both the equilibrium between transmembrane and nontransmembrane helix topography and transmembrane helix positioning. | 2004 | Biochemistry | pmid:15236588 |
| Caesar CE et al. | Membrane interactions of cell-penetrating peptides probed by tryptophan fluorescence and dichroism techniques: correlations of structure to cellular uptake. | 2006 | Biochemistry | pmid:16768464 |
| Persson D et al. | Vesicle membrane interactions of penetratin analogues. | 2004 | Biochemistry | pmid:15323563 |
| BaÅŸaran N et al. | Effect of lipid unsaturation on the binding of native and a mutant form of cytochrome b5 to membranes. | 1999 | Biochemistry | pmid:10563808 |
| Woolley GA and Wallace BA | Temperature dependence of the interaction of alamethicin helices in membranes. | 1993 | Biochemistry | pmid:7690593 |
| Tortorella D et al. | Simple centrifugation method for efficient pelleting of both small and large unilamellar vesicles that allows convenient measurement of protein binding. | 1993 | Biochemistry | pmid:8369285 |
| Ganchev DN et al. | Size and orientation of the lipid II headgroup as revealed by AFM imaging. | 2006 | Biochemistry | pmid:16681392 |
| Abe M et al. | Molecular mechanisms for the induction of peroxidase activity of the cytochrome c-cardiolipin complex. | 2011 | Biochemistry | pmid:21877718 |
| van den Brink-van der Laan E et al. | Small alcohols destabilize the KcsA tetramer via their effect on the membrane lateral pressure. | 2004 | Biochemistry | pmid:15147177 |
| Rutkowski CA et al. | The elasticity of synthetic phospholipid vesicles obtained by photon correlation spectroscopy. | 1991 | Biochemistry | pmid:2043611 |
| Miller CR et al. | Liposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes. | 1998 | Biochemistry | pmid:9737866 |
| Wu F et al. | Stability of annexin V in ternary complexes with Ca2+ and anionic phospholipids: IR studies of monolayer and bulk phases. | 1999 | Biochemistry | pmid:9888820 |
| Liu F and Chong PL | Evidence for a regulatory role of cholesterol superlattices in the hydrolytic activity of secretory phospholipase A2 in lipid membranes. | 1999 | Biochemistry | pmid:10194297 |
| Gomez B and Robinson NC | Phospholipase digestion of bound cardiolipin reversibly inactivates bovine cytochrome bc1. | 1999 | Biochemistry | pmid:10413476 |
| Ostroski M et al. | Analysis of a novel diacylglycerol kinase from Dictyostelium discoideum: DGKA. | 2005 | Biochemistry | pmid:16042397 |
| Bavdek A et al. | Sterol and pH interdependence in the binding, oligomerization, and pore formation of Listeriolysin O. | 2007 | Biochemistry | pmid:17358050 |
| Clayton JC et al. | The cytoplasmic domains of phospholamban and phospholemman associate with phospholipid membrane surfaces. | 2005 | Biochemistry | pmid:16363815 |
| Subczynski WK et al. | Hydrophobic barriers of lipid bilayer membranes formed by reduction of water penetration by alkyl chain unsaturation and cholesterol. | 1994 | Biochemistry | pmid:8011634 |
| Alford D et al. | Fusion of influenza virus with sialic acid-bearing target membranes. | 1994 | Biochemistry | pmid:8117654 |
| Lewis JR and Cafiso DS | Correlation between the free energy of a channel-forming voltage-gated peptide and the spontaneous curvature of bilayer lipids. | 1999 | Biochemistry | pmid:10231547 |
| Hockin MF et al. | A model describing the inactivation of factor Va by APC: bond cleavage, fragment dissociation, and product inhibition. | 1999 | Biochemistry | pmid:10346914 |
| Hunter GW et al. | Phosphatidylethanolamine modulates Ca-ATPase function and dynamics. | 1999 | Biochemistry | pmid:9930998 |
| Antollini SS and Barrantes FJ | Disclosure of discrete sites for phospholipid and sterols at the protein-lipid interface in native acetylcholine receptor-rich membrane. | 1998 | Biochemistry | pmid:9843433 |
| Xu X and London E | The effect of sterol structure on membrane lipid domains reveals how cholesterol can induce lipid domain formation. | 2000 | Biochemistry | pmid:10653627 |
| Abrams FS and London E | Extension of the parallax analysis of membrane penetration depth to the polar region of model membranes: use of fluorescence quenching by a spin-label attached to the phospholipid polar headgroup. | 1993 | Biochemistry | pmid:8399232 |
| Kapralov AA et al. | The hierarchy of structural transitions induced in cytochrome c by anionic phospholipids determines its peroxidase activation and selective peroxidation during apoptosis in cells. | 2007 | Biochemistry | pmid:18004876 |
| Käsbauer M and Bayerl TM | Formation of domains of cationic or anionic lipids in binary lipid mixtures increases the electrostatic coupling strength of water-soluble proteins to supported bilayers. | 1999 | Biochemistry | pmid:10563810 |
| Sitaram N and Nagaraj R | Interaction of the 47-residue antibacterial peptide seminalplasmin and its 13-residue fragment which has antibacterial and hemolytic activities with model membranes. | 1993 | Biochemistry | pmid:8457573 |
| Pécheur EI et al. | Lipid headgroup spacing and peptide penetration, but not peptide oligomerization, modulate peptide-induced fusion. | 1999 | Biochemistry | pmid:9890918 |
| Wang T et al. | Nanomechanical recognition of sphingomyelin-rich membrane domains by atomic force microscopy. | 2012 | Biochemistry | pmid:22148674 |
| Noy N and Blaner WS | Interactions of retinol with binding proteins: studies with rat cellular retinol-binding protein and with rat retinol-binding protein. | 1991 | Biochemistry | pmid:2054343 |
| Grosse W et al. | Structure-based engineering of a minimal porin reveals loop-independent channel closure. | 2014 | Biochemistry | pmid:24988371 |
| Lamparski H et al. | Photoinduced destabilization of liposomes. | 1992 | Biochemistry | pmid:1731924 |
| Chattopadhyay A and McNamee MG | Average membrane penetration depth of tryptophan residues of the nicotinic acetylcholine receptor by the parallax method. | 1991 | Biochemistry | pmid:1854727 |
| Kaetzel MA et al. | Phosphorylation mutants elucidate the mechanism of annexin IV-mediated membrane aggregation. | 2001 | Biochemistry | pmid:11300800 |
| Meijer AB et al. | Configurations of the N-terminal amphipathic domain of the membrane-bound M13 major coat protein. | 2001 | Biochemistry | pmid:11305925 |
| Thibado JK et al. | Influence of High pH and Cholesterol on Single Arginine-Containing Transmembrane Peptide Helices. | 2016 | Biochemistry | pmid:27782382 |
| Wolf DE et al. | Determination of the transbilayer distribution of fluorescent lipid analogues by nonradiative fluorescence resonance energy transfer. | 1992 | Biochemistry | pmid:1550813 |
| Srivastava A et al. | Soluble phosphatidylserine binds to a single identified site in the C2 domain of human factor Va. | 2001 | Biochemistry | pmid:11444970 |
| Chattopadhyay A and Mukherjee S | Fluorophore environments in membrane-bound probes: a red edge excitation shift study. | 1993 | Biochemistry | pmid:8466919 |
| Massey JB and Pownall HJ | The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I. | 2005 | Biochemistry | pmid:16042420 |
| van de Waart P et al. | Interaction of bovine blood clotting factor Va and its subunits with phospholipid vesicles. | 1983 | Biochemistry | pmid:6860639 |
| Patel GJ et al. | The periplasmic chaperone Skp facilitates targeting, insertion, and folding of OmpA into lipid membranes with a negative membrane surface potential. | 2009 | Biochemistry | pmid:19780589 |
| Yu BZ et al. | Structural basis of the anionic interface preference and kcat* activation of pancreatic phospholipase A2. | 2000 | Biochemistry | pmid:11015210 |
| Madden TD et al. | Lipid requirements for coupled cytochrome oxidase vesicles. | 1983 | Biochemistry | pmid:6303398 |
| Hayashibara M and London E | Topography of diphtheria toxin A chain inserted into lipid vesicles. | 2005 | Biochemistry | pmid:15697244 |
| van Kan EJ et al. | Clavanin permeabilizes target membranes via two distinctly different pH-dependent mechanisms. | 2002 | Biochemistry | pmid:12056883 |
| Killian JA and de Kruijff B | Importance of hydration for gramicidin-induced hexagonal HII phase formation in dioleoylphosphatidylcholine model membranes. | 1985 | Biochemistry | pmid:2418875 |
| Yang L et al. | New phases of phospholipids and implications to the membrane fusion problem. | 2003 | Biochemistry | pmid:12779317 |
| Rock P et al. | Ganglioside GM1 and asialo-GM1 at low concentration are preferentially incorporated into the gel phase in two-component, two-phase phosphatidylcholine bilayers. | 1991 | Biochemistry | pmid:1988021 |
| Thorén PE et al. | Membrane binding and translocation of cell-penetrating peptides. | 2004 | Biochemistry | pmid:15035618 |
| Haque ME and Lentz BR | Roles of curvature and hydrophobic interstice energy in fusion: studies of lipid perturbant effects. | 2004 | Biochemistry | pmid:15035621 |
| Nilsson A et al. | Fourier-transform infrared spectroscopy study of dioleoylphosphatidylcholine and monooleoylglycerol in lamellar and cubic liquid crystals. | 1991 | Biochemistry | pmid:1998673 |
| Clark EH et al. | The role of tryptophan residues in an integral membrane protein: diacylglycerol kinase. | 2003 | Biochemistry | pmid:12974643 |
| Kropp TJ et al. | The mipafox-inhibited catalytic domain of human neuropathy target esterase ages by reversible proton loss. | 2004 | Biochemistry | pmid:15035642 |
| Mukherjee S and Chattopadhyay A | Motionally restricted tryptophan environments at the peptide-lipid interface of gramicidin channels. | 1994 | Biochemistry | pmid:7513554 |
| Dhariwal MS et al. | Cytochrome P-450scc induces vesicle aggregation through a secondary interaction at the adrenodoxin binding sites (in competition with protein exchange. | 1991 | Biochemistry | pmid:2036362 |
| Lindblom G et al. | Effect of head-group structure and counterion condensation on phase equilibria in anionic phospholipid-water systems studied by 2H, 23Na, and 31P NMR and X-ray diffraction. | 1991 | Biochemistry | pmid:1932019 |
| Billy D et al. | Inhibition of prothrombinase at macroscopic lipid membranes: competition between antithrombin and prothrombin. | 1995 | Biochemistry | pmid:7577961 |
| Wright CS et al. | Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity. | 2005 | Biochemistry | pmid:16216074 |
| Méthot N et al. | Structure of both the ligand- and lipid-dependent channel-inactive states of the nicotinic acetylcholine receptor probed by FTIR spectroscopy and hydrogen exchange. | 1995 | Biochemistry | pmid:7578128 |
| Mach H and Middaugh CR | Interaction of partially structured states of acidic fibroblast growth factor with phospholipid membranes. | 1995 | Biochemistry | pmid:7543282 |
| Koshy SS et al. | Hydrogen exchange differences between chemoreceptor signaling complexes localize to functionally important subdomains. | 2014 | Biochemistry | pmid:25420045 |
| East JM et al. | Exchange rates and numbers of annular lipids for the calcium and magnesium ion dependent adenosinetriphosphatase. | 1985 | Biochemistry | pmid:2992571 |
| Aliste MP et al. | Molecular dynamics simulations of pentapeptides at interfaces: salt bridge and cation-pi interactions. | 2003 | Biochemistry | pmid:12885230 |
| Moniruzzaman M et al. | Entry of a Six-Residue Antimicrobial Peptide Derived from Lactoferricin B into Single Vesicles and Escherichia coli Cells without Damaging their Membranes. | 2017 | Biochemistry | pmid:28752991 |
| Kahya N et al. | Raft partitioning and dynamic behavior of human placental alkaline phosphatase in giant unilamellar vesicles. | 2005 | Biochemistry | pmid:15895991 |
| Meijer AB et al. | Membrane assembly of the bacteriophage Pf3 major coat protein. | 2000 | Biochemistry | pmid:10821689 |
| Hathcock JJ et al. | Phospholipid regulates the activation of factor X by tissue factor/factor VIIa (TF/VIIa) via substrate and product interactions. | 2005 | Biochemistry | pmid:15924438 |
| Isaacs BS et al. | A domain of membrane-bound blood coagulation factor Va is located far from the phospholipid surface. A fluorescence energy transfer measurement. | 1986 | Biochemistry | pmid:3768326 |
| Ellens H et al. | Fusion of phosphatidylethanolamine-containing liposomes and mechanism of the L alpha-HII phase transition. | 1986 | Biochemistry | pmid:3741846 |
| Providence LL et al. | Gramicidin channel function does not depend on phospholipid chirality. | 1995 | Biochemistry | pmid:8845367 |
| Raja MM and Kinne RK | Interaction of C-terminal loop 13 of sodium-glucose cotransporter SGLT1 with lipid bilayers. | 2005 | Biochemistry | pmid:15966736 |
| Kisel MA et al. | Influence of ethanol and phosphatidylethanol on the activity of pancreatic phospholipase A2. | 2001 | Biochemistry Mosc. | pmid:11255124 |
| Abbott BM et al. | Probing the extended lipid anchorage with cytochrome c and liposomes containing diacylphosphatidylglycerol lipids. | 2018 | Biochim Biophys Acta Biomembr | pmid:29432713 |
| Adhyapak PR et al. | Cholesterol induced asymmetry in DOPC bilayers probed by AFM force spectroscopy. | 2018 | Biochim Biophys Acta Biomembr | pmid:29408513 |
| Fan X et al. | Ib-AMP4 insertion causes surface rearrangement in the phospholipid bilayer of biomembranes: Implications from quartz-crystal microbalance with dissipation. | 2018 | Biochim Biophys Acta Biomembr | pmid:29106975 |
| Mobarak E et al. | How to minimize dye-induced perturbations while studying biomembrane structure and dynamics: PEG linkers as a rational alternative. | 2018 | Biochim Biophys Acta Biomembr | pmid:30028957 |
| Bacellar IOL et al. | Permeability of DOPC bilayers under photoinduced oxidation: Sensitivity to photosensitizer. | 2018 | Biochim Biophys Acta Biomembr | pmid:29886032 |
| Mukherjee P et al. | Lipid and membrane recognition by the oxysterol binding protein and its phosphomimetic mutant using dual polarization interferometry. | 2018 | Biochim Biophys Acta Biomembr | pmid:29879417 |
| Zuidam NJ and Barenholz Y | Electrostatic parameters of cationic liposomes commonly used for gene delivery as determined by 4-heptadecyl-7-hydroxycoumarin. | 1997 | Biochim. Biophys. Acta | pmid:9371413 |
| Taniguchi Y et al. | Rapid phase change of lipid microdomains in giant vesicles induced by conversion of sphingomyelin to ceramide. | 2006 | Biochim. Biophys. Acta | pmid:16580624 |
| Szabó Z et al. | Molecular dynamics of the cyclic lipodepsipeptides' action on model membranes: effects of syringopeptin22A, syringomycin E, and syringotoxin studied by EPR technique. | 2004 | Biochim. Biophys. Acta | pmid:14757227 |
| Marzorati M et al. | Interactions between selected photosensitizers and model membranes: an NMR classification. | 2011 | Biochim. Biophys. Acta | pmid:21334303 |
| Terakawa MS et al. | Membrane-induced initial structure of α-synuclein control its amyloidogenesis on model membranes. | 2018 | Biochim. Biophys. Acta | pmid:29273335 |
| Lindberg DJ et al. | Lipid membranes catalyse the fibril formation of the amyloid-β (1-42) peptide through lipid-fibril interactions that reinforce secondary pathways. | 2017 | Biochim. Biophys. Acta | pmid:28564579 |
| Wu Y and Fletcher GL | Efficacy of antifreeze protein types in protecting liposome membrane integrity depends on phospholipid class. | 2001 | Biochim. Biophys. Acta | pmid:11078953 |
| Hwang F et al. | Anisodamine induces the hexagonal phase in phospholipid liposomes. | 1986 | Biochim. Biophys. Acta | pmid:3741870 |