1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
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| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pal S et al. | Effect of Phospholipid Headgroup Charge on the Structure and Dynamics of Water at the Membrane Interface: A Terahertz Spectroscopic Study. | 2018 | J Phys Chem B | pmid:29543460 |
| Paloncýová M et al. | Amphiphilic drug-like molecules accumulate in a membrane below the head group region. | 2014 | J Phys Chem B | pmid:24417480 |
| Pérez S et al. | Influence of the saturation chain and head group charge of phospholipids in the interaction of hepatitis G virus synthetic peptides. | 2005 | J Phys Chem B | pmid:16853582 |
| Alwarawrah M et al. | A molecular view of the cholesterol condensing effect in DOPC lipid bilayers. | 2010 | J Phys Chem B | pmid:20469902 |
| Vácha R et al. | Mechanism of interaction of monovalent ions with phosphatidylcholine lipid membranes. | 2010 | J Phys Chem B | pmid:20593888 |
| Yan W and Hall SB | Distribution of coexisting solid and fluid phases alters the kinetics of collapse from phospholipid monolayers. | 2006 | J Phys Chem B | pmid:17078641 |
| Fernández ML et al. | Structural and kinetic molecular dynamics study of electroporation in cholesterol-containing bilayers. | 2010 | J Phys Chem B | pmid:20429602 |
| Coll EP et al. | The distribution and conformation of very long-chain plant wax components in a lipid bilayer. | 2007 | J Phys Chem B | pmid:17608528 |
| Terama E et al. | Influence of ethanol on lipid membranes: from lateral pressure profiles to dynamics and partitioning. | 2008 | J Phys Chem B | pmid:18341314 |
| Costard R et al. | Ultrafast vibrational dynamics of water confined in phospholipid reverse micelles. | 2012 | J Phys Chem B | pmid:22546057 |
| Baron R et al. | Comparison of atomic-level and coarse-grained models for liquid hydrocarbons from molecular dynamics configurational entropy estimates. | 2006 | J Phys Chem B | pmid:16623533 |
| Pisani M et al. | Biophysical characterization of complexes of DNA with mixtures of the neutral lipids 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-hexanoylamine or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-dodecanoylamine and 1,2-dioleoyl-sn-glycero-3-phosphocholine in the presence of bivalent metal cations for DNA transfection. | 2011 | J Phys Chem B | pmid:21790167 |
| Zhang L et al. | Ionic Hydrogen Bonds and Lipid Packing Defects Determine the Binding Orientation and Insertion Depth of RecA on Multicomponent Lipid Bilayers. | 2016 | J Phys Chem B | pmid:27095675 |
| Mirjanian D et al. | Splaying of aliphatic tails plays a central role in barrier crossing during liposome fusion. | 2010 | J Phys Chem B | pmid:20701307 |
| Cicuta P et al. | Diffusion of liquid domains in lipid bilayer membranes. | 2007 | J Phys Chem B | pmid:17388499 |
| Lucero A et al. | Effect of hydrocarbon chain and pH on structural and topographical characteristics of phospholipid monolayers. | 2008 | J Phys Chem B | pmid:18517243 |
| Shimobayashi SF and Ichikawa M | Emergence of DNA-encapsulating liposomes from a DNA-lipid blend film. | 2014 | J Phys Chem B | pmid:25133311 |
| Ragoonanan V et al. | Characterization of the effect of NaCl and trehalose on the thermotropic hysteresis of DOPC lipids during freeze/thaw. | 2010 | J Phys Chem B | pmid:21090771 |
| Falkman P et al. | Lyotropic lipid phases confined in cylindrical pores: structure and permeability. | 2011 | J Phys Chem B | pmid:22007791 |
| Klauda JB et al. | Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types. | 2010 | J Phys Chem B | pmid:20496934 |
| Bao R et al. | Atomic force microscopy study of ganglioside GM1 concentration effect on lateral phase separation of sphingomyelin/dioleoylphosphatidylcholine/cholesterol bilayers. | 2011 | J Phys Chem B | pmid:21526782 |
| Nagarajan A et al. | The effects of flanking sequences in the interaction of polyglutamine peptides with a membrane bilayer. | 2014 | J Phys Chem B | pmid:24354677 |
| Kurniawan Y et al. | n-Butanol partitioning and phase behavior in DPPC/DOPC membranes. | 2012 | J Phys Chem B | pmid:22546177 |
| Jurak M | Effect of Lauryl Gallate on Wetting Properties of Organized Thin Phospholipid Films on Mica. | 2016 | J Phys Chem B | pmid:27332889 |
| Toscano-Flores LG et al. | Experimental Determination of High-Order Bending Elastic Constants of Lipid Bilayers. | 2016 | J Phys Chem B | pmid:27267752 |
| Raghunathan M et al. | Structure and elasticity of lipid membranes with genistein and daidzein bioflavinoids using X-ray scattering and MD simulations. | 2012 | J Phys Chem B | pmid:22324769 |
| Hughes ZE et al. | Molecular dynamics simulations of the interactions of DMSO with DPPC and DOPC phospholipid membranes. | 2012 | J Phys Chem B | pmid:22947053 |
| Pan J and Khadka NK | Kinetic Defects Induced by Melittin in Model Lipid Membranes: A Solution Atomic Force Microscopy Study. | 2016 | J Phys Chem B | pmid:27167473 |
| Perlo J et al. | Temperature and size-dependence of membrane molecular dynamics in unilamellar vesicles by fast field-cycling NMR relaxometry. | 2011 | J Phys Chem B | pmid:21405038 |
| Dai J et al. | Simulation of the lo-ld phase boundary in DSPC/DOPC/cholesterol ternary mixtures using pairwise interactions. | 2011 | J Phys Chem B | pmid:21271714 |
| Negishi M et al. | Emergence of superstructures from a homogeneous lipid sphere. | 2009 | J Phys Chem B | pmid:19243102 |
| Lamberson ER et al. | Path dependence of three-phase or two-phase end points in fluid binary lipid mixtures. | 2009 | J Phys Chem B | pmid:19243147 |
| Lim JB et al. | Update of the cholesterol force field parameters in CHARMM. | 2012 | J Phys Chem B | pmid:22136112 |
| Gillmor SD and Weiss PS | Dimpled vesicles: the interplay between energetics and transient pores. | 2008 | J Phys Chem B | pmid:18837538 |
| Bernchou U et al. | Growth of solid domains in model membranes: quantitative image analysis reveals a strong correlation between domain shape and spatial position. | 2009 | J Phys Chem B | pmid:19296622 |
| Hughes ZE et al. | The effects of cryosolvents on DOPC-β-sitosterol bilayers determined from molecular dynamics simulations. | 2013 | J Phys Chem B | pmid:23445456 |
| Zidovska A et al. | The role of cholesterol and structurally related molecules in enhancing transfection of cationic liposome-DNA complexes. | 2009 | J Phys Chem B | pmid:19354307 |
| Bailey KA and Schultz ZD | Tracking Bulk and Interfacial Diffusion Using Multiplex Coherent Anti-Stokes Raman Scattering Correlation Spectroscopy. | 2016 | J Phys Chem B | pmid:27322504 |
| Fu D et al. | Hyperspectral imaging with stimulated Raman scattering by chirped femtosecond lasers. | 2013 | J Phys Chem B | pmid:23256635 |
| Lu L and Voth GA | Systematic coarse-graining of a multicomponent lipid bilayer. | 2009 | J Phys Chem B | pmid:19138138 |
| Polyansky AA et al. | Adaptation of a membrane-active peptide to heterogeneous environment. II. The role of mosaic nature of the membrane surface. | 2009 | J Phys Chem B | pmid:19125636 |
| Kardash ME et al. | Heterogeneities in Cholesterol-Containing Model Membranes Observed by Pulsed Electron Paramagnetic Resonance of Spin Labels. | 2015 | J Phys Chem B | pmid:25965099 |
| Polyansky AA et al. | Adaptation of a membrane-active peptide to heterogeneous environment. I. Structural plasticity of the peptide. | 2009 | J Phys Chem B | pmid:19125640 |
| Panahi A and Brooks CL | Membrane environment modulates the pKa values of transmembrane helices. | 2015 | J Phys Chem B | pmid:25734901 |
| Khelashvili G and Harries D | How cholesterol tilt modulates the mechanical properties of saturated and unsaturated lipid membranes. | 2013 | J Phys Chem B | pmid:23323733 |
| Paloncýová M et al. | Molecular insight into affinities of drugs and their metabolites to lipid bilayers. | 2013 | J Phys Chem B | pmid:23387302 |
| Piatkowski L et al. | Probing the distribution of water molecules hydrating lipid membranes with ultrafast Förster vibrational energy transfer. | 2013 | J Phys Chem B | pmid:23360328 |
| Braun AR et al. | Comparing simulations of lipid bilayers to scattering data: the GROMOS 43A1-S3 force field. | 2013 | J Phys Chem B | pmid:23560979 |
| Vogtt K et al. | Microdomains in lipid vesicles: structure and distribution assessed by small-angle neutron scattering. | 2010 | J Phys Chem B | pmid:20369805 |
| Madej BD et al. | A Parameterization of Cholesterol for Mixed Lipid Bilayer Simulation within the Amber Lipid14 Force Field. | 2015 | J Phys Chem B | pmid:26359797 |
| Fernández ML and Reigada R | Effects of dimethyl sulfoxide on lipid membrane electroporation. | 2014 | J Phys Chem B | pmid:25035931 |
| Srividya N et al. | Determination of the line tension of giant vesicles from pore-closing dynamics. | 2008 | J Phys Chem B | pmid:18503265 |
| Scheidt HA et al. | Transmembrane Helix Induces Membrane Fusion through Lipid Binding and Splay. | 2018 | J Phys Chem Lett | pmid:29799756 |
| Donaldson SH and de Aguiar HB | Molecular Imaging of Cholesterol and Lipid Distributions in Model Membranes. | 2018 | J Phys Chem Lett | pmid:29521507 |
| Grau-Campistany A et al. | Extending the Hydrophobic Mismatch Concept to Amphiphilic Membranolytic Peptides. | 2016 | J Phys Chem Lett | pmid:26963560 |
| Sánchez-Murcia PA et al. | Exciton Localization on Ru-Based Photosensitizers Induced by Binding to Lipid Membranes. | 2018 | J Phys Chem Lett | pmid:29363982 |
| Gupta S et al. | Dynamics of Phospholipid Membranes beyond Thermal Undulations. | 2018 | J Phys Chem Lett | pmid:29754484 |
| Yoon YZ et al. | Mechanical properties of ternary lipid membranes near a liquid-liquid phase separation boundary. | 2010 | J Phys Condens Matter | pmid:21389358 |
| Orsi M et al. | Coarse-grain modelling of DMPC and DOPC lipid bilayers. | 2010 | J Phys Condens Matter | pmid:21389551 |
| Zhang HY and Hill RJ | Concentration dependence of lipopolymer self-diffusion in supported bilayer membranes. | 2011 | J R Soc Interface | pmid:20504804 |
| Barnoud J et al. | C₆₀ fullerene promotes lung monolayer collapse. | 2015 | J R Soc Interface | pmid:25589571 |
| Barriga HM et al. | Droplet interface bilayer reconstitution and activity measurement of the mechanosensitive channel of large conductance from Escherichia coli. | 2014 | J R Soc Interface | pmid:25008079 |
| Kent B et al. | Localization of trehalose in partially hydrated DOPC bilayers: insights into cryoprotective mechanisms. | 2014 | J R Soc Interface | pmid:24647907 |
| Andorko JI et al. | Intra-lymph node injection of biodegradable polymer particles. | 2014 | J Vis Exp | pmid:24430972 |
| Unsay JD et al. | Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers. | 2015 | J Vis Exp | pmid:26273958 |
| Chen B et al. | Physical structures in soybean oil and their impact on lipid oxidation. | 2010 | J. Agric. Food Chem. | pmid:20964436 |
| Hane F et al. | Amyloid-β aggregation on model lipid membranes: an atomic force microscopy study. | 2011 | J. Alzheimers Dis. | pmid:21694459 |
| Yu Y et al. | Vesicle budding induced by a pore-forming peptide. | 2010 | J. Am. Chem. Soc. | pmid:20000420 |
| Ivanov I et al. | Characterization of nonbiological antimicrobial polymers in aqueous solution and at water-lipid interfaces from all-atom molecular dynamics. | 2006 | J. Am. Chem. Soc. | pmid:16464062 |
| Osella S and Knippenberg S | Triggering On/Off States of Photoswitchable Probes in Biological Environments. | 2017 | J. Am. Chem. Soc. | pmid:28252300 |
| Shearman GC et al. | A 3-D hexagonal inverse micellar lyotropic phase. | 2009 | J. Am. Chem. Soc. | pmid:19146371 |
| Ewert KK et al. | A columnar phase of dendritic lipid-based cationic liposome-DNA complexes for gene delivery: hexagonally ordered cylindrical micelles embedded in a DNA honeycomb lattice. | 2006 | J. Am. Chem. Soc. | pmid:16551108 |
| Cans AS et al. | Positioning lipid membrane domains in giant vesicles by micro-organization of aqueous cytoplasm mimic. | 2008 | J. Am. Chem. Soc. | pmid:18479139 |
| Avakyan N et al. | Long-Range Ordering of Blunt-Ended DNA Tiles on Supported Lipid Bilayers. | 2017 | J. Am. Chem. Soc. | pmid:28783358 |
| Ristori S et al. | Synthesis and liposome insertion of a new poly(carboranylalkylthio)porphyrazine to improve potentiality in multiple-approach cancer therapy. | 2007 | J. Am. Chem. Soc. | pmid:17298062 |
| Weber ME et al. | Dynamic assessment of bilayer thickness by varying phospholipid and hydraphile synthetic channel chain lengths. | 2005 | J. Am. Chem. Soc. | pmid:15643888 |
| Yang L et al. | Synthetic antimicrobial oligomers induce a composition-dependent topological transition in membranes. | 2007 | J. Am. Chem. Soc. | pmid:17880067 |
| de Joannis J et al. | Atomistic simulation of cholesterol effects on miscibility of saturated and unsaturated phospholipids: implications for liquid-ordered/liquid-disordered phase coexistence. | 2011 | J. Am. Chem. Soc. | pmid:21341653 |
| Stengel G et al. | DNA-induced programmable fusion of phospholipid vesicles. | 2007 | J. Am. Chem. Soc. | pmid:17629277 |
| Ulmschneider MB et al. | Mechanism and kinetics of peptide partitioning into membranes from all-atom simulations of thermostable peptides. | 2010 | J. Am. Chem. Soc. | pmid:20163187 |
| Domene C et al. | The role of conformation in ion permeation in a K+ channel. | 2008 | J. Am. Chem. Soc. | pmid:18293969 |
| Jarroux N et al. | Shape-tunable polymer nodules grown from liposomes via ring-opening metathesis polymerization. | 2004 | J. Am. Chem. Soc. | pmid:15584718 |
| Yu Y and Granick S | Pearling of lipid vesicles induced by nanoparticles. | 2009 | J. Am. Chem. Soc. | pmid:19775107 |
| Rozovsky S et al. | Formation and spatio-temporal evolution of periodic structures in lipid bilayers. | 2005 | J. Am. Chem. Soc. | pmid:15631436 |
| Werts MH et al. | Strong modulation of two-photon excited fluorescence of quadripolar dyes by (de)protonation. | 2004 | J. Am. Chem. Soc. | pmid:15600310 |
| Bernchou U et al. | Texture of lipid bilayer domains. | 2009 | J. Am. Chem. Soc. | pmid:19702259 |
| Li L et al. | Budding dynamics of multicomponent tubular vesicles. | 2005 | J. Am. Chem. Soc. | pmid:16366538 |
| MacCallum JL and Tieleman DP | Computer simulation of the distribution of hexane in a lipid bilayer: spatially resolved free energy, entropy, and enthalpy profiles. | 2006 | J. Am. Chem. Soc. | pmid:16390139 |
| Tieleman DP et al. | Simulation of pore formation in lipid bilayers by mechanical stress and electric fields. | 2003 | J. Am. Chem. Soc. | pmid:12785774 |
| Weise K et al. | Influence of the lipidation motif on the partitioning and association of N-Ras in model membrane subdomains. | 2009 | J. Am. Chem. Soc. | pmid:19133719 |
| Yaroslavov AA et al. | Biomembrane sensitivity to structural changes in bound polymers. | 2009 | J. Am. Chem. Soc. | pmid:19152326 |
| Becucci L et al. | Pore formation by 6-ketocholestanol in phospholipid monolayers and its interpretation by a general nucleation-and-growth model accounting for the sigmoidal shape of voltage-clamp curves of ion channels. | 2003 | J. Am. Chem. Soc. | pmid:12656611 |
| Spurlin TA and Gewirth AA | Charge dependence of a nanoscale supercrystal phase in a supported lipid bilayer. | 2007 | J. Am. Chem. Soc. | pmid:17845046 |
| Liang H et al. | Roles of anionic and cationic template components in biomineralization of CdS nanorods using self-assembled DNA-membrane complexes. | 2004 | J. Am. Chem. Soc. | pmid:15506781 |
| Kapoor S et al. | Pressure modulation of Ras-membrane interactions and intervesicle transfer. | 2013 | J. Am. Chem. Soc. | pmid:23560466 |
| Litt J et al. | Enhancing protein stability by adsorption onto raftlike lipid domains. | 2009 | J. Am. Chem. Soc. | pmid:19385631 |
| Zaitseva E et al. | Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: the Meta II(a) conformational substate. | 2010 | J. Am. Chem. Soc. | pmid:20230054 |
| Banga RJ et al. | Liposomal spherical nucleic acids. | 2014 | J. Am. Chem. Soc. | pmid:24983505 |
| Rottem S et al. | Incorporation and modification of exogenous phosphatidylcholines by mycoplasmas. | 1986 | J. Bacteriol. | pmid:3087959 |
| Kaizu T et al. | A saturation transfer electron spin resonance study on the break in the Arrhenius plot for the rotational motion of Ca2+-dependent adenosine triphosphatase molecules in purified and lipid-replaced preparations of rabbit skeletal muscle sarcoplasmic reticulum. | 1980 | J. Biochem. | pmid:6257672 |