1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| van Liempd JP et al. | Nonselective squeeze-out of dioleoylphosphatidylcholine and dioleoylphosphatidylglycerol from binary mixed monolayers with dipalmitoylphosphatidylcholine. | 1987 | Biochim. Biophys. Acta | pmid:3814598 |
| Kulig W et al. | Experimental determination and computational interpretation of biophysical properties of lipid bilayers enriched by cholesteryl hemisuccinate. | 2015 | Biochim. Biophys. Acta | pmid:25450348 |
| Janas T and Walińska K | The effect of hexadecaprenyl diphosphate on phospholipid membranes. | 2000 | Biochim. Biophys. Acta | pmid:10727614 |
| Fenske DB and Cullis PR | Chemical exchange between lamellar and non-lamellar lipid phases. A one- and two-dimensional 31P-NMR study. | 1992 | Biochim. Biophys. Acta | pmid:1637844 |
| Choucair A et al. | Preferential accumulation of Abeta(1-42) on gel phase domains of lipid bilayers: an AFM and fluorescence study. | 2007 | Biochim. Biophys. Acta | pmid:17052685 |
| Addona GH et al. | Where does cholesterol act during activation of the nicotinic acetylcholine receptor? | 1998 | Biochim. Biophys. Acta | pmid:9545586 |
| Francius G et al. | Nanoscale membrane activity of surfactins: influence of geometry, charge and hydrophobicity. | 2008 | Biochim. Biophys. Acta | pmid:18455997 |
| Sanders JC et al. | Formation of non-bilayer structures induced by M13 coat protein depends on the conformation of the protein. | 1992 | Biochim. Biophys. Acta | pmid:1390851 |
| Schagina LV et al. | Sterol specific inactivation of gramicidin A induced membrane cation permeability. | 1992 | Biochim. Biophys. Acta | pmid:1380301 |
| Berquand A et al. | Real-time imaging of drug-membrane interactions by atomic force microscopy. | 2004 | Biochim. Biophys. Acta | pmid:15328052 |
| Raines DE and Krishnan NS | Agonist binding and affinity state transitions in reconstituted nicotinic acetylcholine receptors revealed by single and sequential mixing stopped-flow fluorescence spectroscopies. | 1998 | Biochim. Biophys. Acta | pmid:9814855 |
| Kaneshina S et al. | Barotropic phase transitions of dioleoylphosphatidylcholine and stearoyl-oleoylphosphatidylcholine bilayer membranes. | 1998 | Biochim. Biophys. Acta | pmid:9814847 |
| Christ K et al. | The role of lipid II in membrane binding of and pore formation by nisin analyzed by two combined biosensor techniques. | 2007 | Biochim. Biophys. Acta | pmid:17254547 |
| Oliver AE et al. | Interactions of arbutin with dry and hydrated bilayers. | 1998 | Biochim. Biophys. Acta | pmid:9518563 |
| Abadji VC et al. | The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles. | 1993 | Biochim. Biophys. Acta | pmid:8466926 |
| Bouchard M et al. | Comparison between the dynamics of lipid/gramicidin A systems in the lamellar and hexagonal phases: a solid-state 13C NMR study. | 1998 | Biochim. Biophys. Acta | pmid:9858726 |
| Besenicar MP et al. | Kinetics of cholesterol extraction from lipid membranes by methyl-beta-cyclodextrin--a surface plasmon resonance approach. | 2008 | Biochim. Biophys. Acta | pmid:18068686 |
| Ottaviani MF et al. | The macroscopic organization of reconstituted M13 coat protein-phospholipid systems. An EPR spectroscopy and polarizing microscope study. | 1993 | Biochim. Biophys. Acta | pmid:8399296 |
| Murata M et al. | Fusion of dioleoylphosphatidylcholine vesicles induced by an amphiphilic cationic peptide and oligophosphates at neutral pH. | 1993 | Biochim. Biophys. Acta | pmid:8399311 |
| Marquês JT et al. | Ethanol effects on binary and ternary supported lipid bilayers with gel/fluid domains and lipid rafts. | 2011 | Biochim. Biophys. Acta | pmid:20955684 |
| Kapoor S et al. | Temperature-pressure phase diagram of a heterogeneous anionic model biomembrane system: results from a combined calorimetry, spectroscopy and microscopy study. | 2011 | Biochim. Biophys. Acta | pmid:21262194 |
| Duff KC et al. | The location of amantadine hydrochloride and free base within phospholipid multilayers: a neutron and X-ray diffraction study. | 1993 | Biochim. Biophys. Acta | pmid:8422405 |
| Nelson A et al. | Interaction of hydrophobic organic compounds with mercury adsorbed dioleoylphosphatidylcholine monolayers. | 1990 | Biochim. Biophys. Acta | pmid:1967949 |
| Michelangeli F et al. | The conformation of pyrethroids bound to lipid bilayers. | 1990 | Biochim. Biophys. Acta | pmid:2207119 |
| In 't Veld G et al. | Acidic phospholipids are required during solubilization of amino acid transport systems of Lactococcus lactis. | 1992 | Biochim. Biophys. Acta | pmid:1547262 |
| Freudenthal O et al. | Nanoscale investigation of the interaction of colistin with model phospholipid membranes by Langmuir technique, and combined infrared and force spectroscopies. | 2016 | Biochim. Biophys. Acta | pmid:27480806 |
| Harrison PL et al. | Phospholipid dependent mechanism of smp24, an α-helical antimicrobial peptide from scorpion venom. | 2016 | Biochim. Biophys. Acta | pmid:27480803 |
| Killian JA et al. | Phase separation and hexagonal HII phase formation by gramicidins A, B and C in dioleoylphosphatidylcholine model membranes. A study on the role of the tryptophan residues. | 1987 | Biochim. Biophys. Acta | pmid:2434129 |
| Demel RA et al. | Insect apolipophorin III: interaction of locust apolipophorin III with diacylglycerol. | 1992 | Biochim. Biophys. Acta | pmid:1543737 |
| Bonneau S et al. | Dynamics of pH-dependent self-association and membrane binding of a dicarboxylic porphyrin: a study with small unilamellar vesicles. | 2004 | Biochim. Biophys. Acta | pmid:14967478 |
| Sakamoto S et al. | Investigation of interfacial behavior of glycyrrhizin with a lipid raft model via a Langmuir monolayer study. | 2013 | Biochim. Biophys. Acta | pmid:23333324 |
| Petruzielo RS et al. | Phase behavior and domain size in sphingomyelin-containing lipid bilayers. | 2013 | Biochim. Biophys. Acta | pmid:23337475 |
| Webb MS et al. | Effects of plant sterols on the hydration and phase behavior of DOPE/DOPC mixtures. | 1995 | Biochim. Biophys. Acta | pmid:7488628 |
| Mavromoustakos T et al. | Effects of the anesthetic steroid alphaxalone and its inactive delta 16-analog on the thermotropic properties of membrane bilayers. A model for membrane perturbation. | 1995 | Biochim. Biophys. Acta | pmid:7488631 |
| Wacklin HP et al. | Distribution of reaction products in phospholipase A2 hydrolysis. | 2007 | Biochim. Biophys. Acta | pmid:17355873 |
| Becucci L et al. | Channel-forming activity of syringomycin E in two mercury-supported biomimetic membranes. | 2015 | Biochim. Biophys. Acta | pmid:25554594 |
| Zhao J et al. | Phase studies of model biomembranes: complex behavior of DSPC/DOPC/cholesterol. | 2007 | Biochim. Biophys. Acta | pmid:17825247 |
| Lhor M et al. | Structure of the N-terminal segment of human retinol dehydrogenase 11 and its preferential lipid binding using model membranes. | 2015 | Biochim. Biophys. Acta | pmid:25542782 |
| Bulacu M and Sevink GJ | Computational insight in the role of fusogenic lipopeptides at the onset of liposome fusion. | 2015 | Biochim. Biophys. Acta | pmid:25528473 |
| Norris FA and Powell GL | The apparent permeability coefficient for proton flux through phosphatidylcholine vesicles is dependent on the direction of flux. | 1990 | Biochim. Biophys. Acta | pmid:2176102 |
| Brewer J et al. | Multiphoton excitation fluorescence microscopy in planar membrane systems. | 2010 | Biochim. Biophys. Acta | pmid:20226161 |
| Haldar S et al. | Membrane interaction of the N-terminal domain of chemokine receptor CXCR1. | 2010 | Biochim. Biophys. Acta | pmid:20226759 |
| Nomura SM et al. | Changes in the morphology of cell-size liposomes in the presence of cholesterol: formation of neuron-like tubes and liposome networks. | 2005 | Biochim. Biophys. Acta | pmid:15893519 |
| Drolle E et al. | Effect of melatonin and cholesterol on the structure of DOPC and DPPC membranes. | 2013 | Biochim. Biophys. Acta | pmid:23714288 |
| Busi E et al. | On the mechanism of ion transport through lipid membranes mediated by PEGylated cyclic oligosaccharides (CyPLOS): an ESR study. | 2013 | Biochim. Biophys. Acta | pmid:23714289 |
| Booker RD and Sum AK | Biophysical changes induced by xenon on phospholipid bilayers. | 2013 | Biochim. Biophys. Acta | pmid:23376329 |
| Pompeo G et al. | AFM characterization of solid-supported lipid multilayers prepared by spin-coating. | 2005 | Biochim. Biophys. Acta | pmid:15869743 |
| Gomide AB et al. | Disrupting membrane raft domains by alkylphospholipids. | 2013 | Biochim. Biophys. Acta | pmid:23376656 |
| Buckland AG et al. | Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2. | 1998 | Biochim. Biophys. Acta | pmid:9487141 |
| Shynkar VV et al. | Two-color fluorescent probes for imaging the dipole potential of cell plasma membranes. | 2005 | Biochim. Biophys. Acta | pmid:15921656 |