1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Benz R | Structural requirement for the rapid movement of charged molecules across membranes. Experiments with tetraphenylborate analogues. | 1988 | Biophys. J. | pmid:3416031 |
| Finean JB and Hutchinson AL | X-ray diffraction studies of lipid phase transitions in cholesterol-rich membranes at sub-zero temperatures. | 1988 | Chem. Phys. Lipids | pmid:3338100 |
| Goodrich RP et al. | Modification of lipid phase behavior with membrane-bound cryoprotectants. | 1988 | Biochim. Biophys. Acta | pmid:3342228 |
| Janas T and Tien HT | Influence of dolichyl phosphate on permeability and stability of bilayer lipid membranes. | 1988 | Biochim. Biophys. Acta | pmid:3355837 |
| Gong EL et al. | Transformation of large discoidal complexes of apolipoprotein A-I and phosphatidylcholine by lecithin-cholesterol acyltransferase. | 1988 | Biochim. Biophys. Acta | pmid:3132984 |
| Stankowski S et al. | Voltage-dependent pore activity of the peptide alamethicin correlated with incorporation in the membrane: salt and cholesterol effects. | 1988 | Biochim. Biophys. Acta | pmid:2453215 |
| Yoshikawa K et al. | Electrical oscillation and fluctuation in phospholipid membranes. Phospholipids can form a channel without protein. | 1988 | Biophys. Chem. | pmid:2455554 |
| Van Mau N et al. | Mixed monolayers of linear gramicidins and phospholipid. Surface pressure and surface potential studies. | 1988 | Biophys. J. | pmid:2462931 |
| Grasso P et al. | Reconstitution of hormone-responsive detergent-solubilized follicle stimulating hormone receptors into liposomes. | 1988 | Mol. Endocrinol. | pmid:3138532 |
| González JE and Wisnieski BJ | An endosomal model for acid triggering of diphtheria toxin translocation. | 1988 | J. Biol. Chem. | pmid:3139667 |