1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chattopadhyay A et al. | Photophysics of a neurotransmitter: ionization and spectroscopic properties of serotonin. | 1996 | Biophys. J. | pmid:8889169 |
| Beattie ME et al. | Sterol structure determines miscibility versus melting transitions in lipid vesicles. | 2005 | Biophys. J. | pmid:15951379 |
| Chattopadhyay A et al. | Ionization, partitioning, and dynamics of tryptophan octyl ester: implications for membrane-bound tryptophan residues. | 1997 | Biophys. J. | pmid:9251800 |
| Yan W et al. | The collapse of monolayers containing pulmonary surfactant phospholipids is kinetically determined. | 2005 | Biophys. J. | pmid:15985424 |
| Speijer H et al. | Critical micelle concentrations and stirring are rate limiting in the loss of lipid mass during membrane degradation by phospholipase A2. | 1996 | Biophys. J. | pmid:9172747 |
| Marsh D | Intrinsic curvature in normal and inverted lipid structures and in membranes. | 1996 | Biophys. J. | pmid:9172748 |
| Cheng KH and Somerharju P | Effects of unsaturation and curvature on the transverse distribution of intramolecular dynamics of dipyrenyl lipids. | 1996 | Biophys. J. | pmid:9172752 |
| King GI and White SH | Determining bilayer hydrocarbon thickness from neutron diffraction measurements using strip-function models. | 1986 | Biophys. J. | pmid:3708089 |
| Filippov A et al. | The effect of cholesterol on the lateral diffusion of phospholipids in oriented bilayers. | 2003 | Biophys. J. | pmid:12719238 |
| Chen Z and Rand RP | The influence of cholesterol on phospholipid membrane curvature and bending elasticity. | 1997 | Biophys. J. | pmid:9199791 |
| Benz RW et al. | Diffraction-based density restraints for membrane and membrane-peptide molecular dynamics simulations. | 2006 | Biophys. J. | pmid:16950837 |
| Klösgen B and Helfrich W | Cryo-transmission electron microscopy of a superstructure of fluid dioleoylphosphatidylcholine (DOPC) membranes. | 1997 | Biophys. J. | pmid:9414216 |
| Morein S et al. | Influence of membrane-spanning alpha-helical peptides on the phase behavior of the dioleoylphosphatidylcholine/water system. | 1997 | Biophys. J. | pmid:9414221 |
| Denisov G et al. | Binding of basic peptides to membranes produces lateral domains enriched in the acidic lipids phosphatidylserine and phosphatidylinositol 4,5-bisphosphate: an electrostatic model and experimental results. | 1998 | Biophys. J. | pmid:9533686 |
| Kragh-Hansen U et al. | The mechanism of detergent solubilization of liposomes and protein-containing membranes. | 1998 | Biophys. J. | pmid:9826614 |
| Chen Z and Rand RP | Comparative study of the effects of several n-alkanes on phospholipid hexagonal phases. | 1998 | Biophys. J. | pmid:9533705 |
| Edmiston PL and Saavedra SS | Molecular orientation distributions in protein films: III. Yeast cytochrome c immobilized on pyridyl disulfide-capped phospholipid bilayers. | 1998 | Biophys. J. | pmid:9533712 |
| van den Bogaart G et al. | On the decrease in lateral mobility of phospholipids by sugars. | 2007 | Biophys. J. | pmid:17142271 |
| Raghuraman H and Chattopadhyay A | Orientation and dynamics of melittin in membranes of varying composition utilizing NBD fluorescence. | 2007 | Biophys. J. | pmid:17114219 |
| Nazarov PV et al. | FRET study of membrane proteins: determination of the tilt and orientation of the N-terminal domain of M13 major coat protein. | 2007 | Biophys. J. | pmid:17114224 |
| Glassinger E and Raphael RM | Influence of thermally driven surface undulations on tethers formed from bilayer membranes. | 2006 | Biophys. J. | pmid:16648163 |
| Victorov AV et al. | Packing constraints and electrostatic surface potentials determine transmembrane asymmetry of phosphatidylethanol. | 1997 | Biophys. J. | pmid:9168034 |
| Bakás L et al. | Reversible adsorption and nonreversible insertion of Escherichia coli alpha-hemolysin into lipid bilayers. | 1996 | Biophys. J. | pmid:8889162 |
| Fernandes F et al. | Quantification of Protein-Lipid Selectivity using FRET: Application to the M13 Major Coat Protein. | 2004 | Biophys. J. | pmid:15240469 |
| Wagner K et al. | Interactions of the human calcitonin fragment 9-32 with phospholipids: a monolayer study. | 2004 | Biophys. J. | pmid:15240473 |
| MacCallum JL et al. | Transfer of arginine into lipid bilayers is nonadditive. | 2011 | Biophys. J. | pmid:21723820 |
| Becucci L et al. | Gel-phase microdomains and lipid rafts in monolayers affect the redox properties of ubiquinone-10. | 2011 | Biophys. J. | pmid:21723823 |
| Bradshaw JP et al. | Interaction of substance P with phospholipid bilayers: A neutron diffraction study. | 1998 | Biophys. J. | pmid:9675189 |
| Gulik A et al. | A conformation transition of lung surfactant lipids probably involved in respiration. | 1994 | Biophys. J. | pmid:7811921 |
| Tristram-Nagle S et al. | Structure and interactions of fully hydrated dioleoylphosphatidylcholine bilayers. | 1998 | Biophys. J. | pmid:9675192 |
| Contino PB et al. | Use of an oriented transmembrane protein to probe the assembly of a supported phospholipid bilayer. | 1994 | Biophys. J. | pmid:7811922 |
| Harvie P et al. | Characterization of lipid DNA interactions. I. Destabilization of bound lipids and DNA dissociation. | 1998 | Biophys. J. | pmid:9675205 |
| Hristova K and White SH | Determination of the hydrocarbon core structure of fluid dioleoylphosphocholine (DOPC) bilayers by x-ray diffraction using specific bromination of the double-bonds: effect of hydration. | 1998 | Biophys. J. | pmid:9591668 |
| Ben-Tal N et al. | Binding of small basic peptides to membranes containing acidic lipids: theoretical models and experimental results. | 1996 | Biophys. J. | pmid:8842196 |
| Sun Y et al. | The bound states of amphipathic drugs in lipid bilayers: study of curcumin. | 2008 | Biophys. J. | pmid:18515370 |
| Barranger-Mathys M and Cafiso DS | Collisions between helical peptides in membranes monitored using electron paramagnetic resonance: evidence that alamethicin is monomeric in the absence of a membrane potential. | 1994 | Biophys. J. | pmid:7918984 |
| Weinreb G and Lentz BR | Analysis of membrane fusion as a two-state sequential process: evaluation of the stalk model. | 2007 | Biophys. J. | pmid:17369418 |
| Larsen JB et al. | Membrane Curvature and Lipid Composition Synergize To Regulate N-Ras Anchor Recruitment. | 2017 | Biophys. J. | pmid:28738989 |
| Gudheti MV et al. | Imaging and shape analysis of GUVs as model plasma membranes: effect of trans DOPC on membrane properties. | 2007 | Biophys. J. | pmid:17513374 |
| Ulrich AS and Watts A | Molecular response of the lipid headgroup to bilayer hydration monitored by 2H-NMR. | 1994 | Biophys. J. | pmid:8061193 |
| Cambrea LR et al. | Effect of ions on the organization of phosphatidylcholine/phosphatidic acid bilayers. | 2007 | Biophys. J. | pmid:17483164 |
| Epand RM and Epand RF | Calorimetric detection of curvature strain in phospholipid bilayers. | 1994 | Biophys. J. | pmid:8061194 |
| de Almeida RF et al. | Complexity of lipid domains and rafts in giant unilamellar vesicles revealed by combining imaging and microscopic and macroscopic time-resolved fluorescence. | 2007 | Biophys. J. | pmid:17449668 |
| Klösgen B et al. | Dielectric spectroscopy as a sensor of membrane headgroup mobility and hydration. | 1996 | Biophys. J. | pmid:8968595 |
| Snitsarev V et al. | Fluorescent detection of Zn(2+)-rich vesicles with Zinquin: mechanism of action in lipid environments. | 2001 | Biophys. J. | pmid:11222314 |
| Le Saux A et al. | Membrane molecule reorientation in an electric field recorded by attenuated total reflection Fourier-transform infrared spectroscopy. | 2001 | Biophys. J. | pmid:11159405 |
| Hristova K et al. | Structure, location, and lipid perturbations of melittin at the membrane interface. | 2001 | Biophys. J. | pmid:11159447 |
| Lehtonen JY et al. | Characteristics of the binding of tacrine to acidic phospholipids. | 1996 | Biophys. J. | pmid:9172742 |
| Nicolini C et al. | Pressure tuning of the morphology of heterogeneous lipid vesicles: a two-photon-excitation fluorescence microscopy study. | 2006 | Biophys. J. | pmid:16877511 |
| Mashl RJ et al. | Molecular simulation of dioleoylphosphatidylcholine lipid bilayers at differing levels of hydration. | 2001 | Biophys. J. | pmid:11720971 |
| Cheng CY et al. | DMSO induces dehydration near lipid membrane surfaces. | 2015 | Biophys. J. | pmid:26200868 |
| Chiantia S et al. | Asymmetric GUVs prepared by MβCD-mediated lipid exchange: an FCS study. | 2011 | Biophys. J. | pmid:21190650 |
| Moring J et al. | Interaction of the NMDA receptor noncompetitive antagonist MK-801 with model and native membranes. | 1994 | Biophys. J. | pmid:7696477 |
| Portet T and Dimova R | A new method for measuring edge tensions and stability of lipid bilayers: effect of membrane composition. | 2010 | Biophys. J. | pmid:21081074 |
| Coorssen JR and Rand RP | Structural effects of neutral lipids on divalent cation-induced interactions of phosphatidylserine-containing bilayers. | 1995 | Biophys. J. | pmid:7756521 |
| Olsen BN et al. | The structural basis of cholesterol accessibility in membranes. | 2013 | Biophys. J. | pmid:24138860 |
| Giocondi MC et al. | Use of cyclodextrin for AFM monitoring of model raft formation. | 2004 | Biophys. J. | pmid:14747321 |
| Davis JH et al. | Phase equilibria in DOPC/DPPC-d62/cholesterol mixtures. | 2009 | Biophys. J. | pmid:19167302 |
| Mertins O et al. | Physical damage on giant vesicles membrane as a result of methylene blue photoirradiation. | 2014 | Biophys. J. | pmid:24411248 |
| Nelson A | Conducting gramicidin channel activity in phospholipid monolayers. | 2001 | Biophys. J. | pmid:11371445 |
| Tekle E et al. | Selective field effects on intracellular vacuoles and vesicle membranes with nanosecond electric pulses. | 2005 | Biophys. J. | pmid:15821165 |
| Sciacca MF et al. | The Role of Cholesterol in Driving IAPP-Membrane Interactions. | 2016 | Biophys. J. | pmid:27410742 |
| Szule JA et al. | The effects of acyl chain length and saturation of diacylglycerols and phosphatidylcholines on membrane monolayer curvature. | 2002 | Biophys. J. | pmid:12124279 |
| Savić F et al. | Geometry of the Contact Zone between Fused Membrane-Coated Beads Mimicking Cell-Cell Fusion. | 2016 | Biophys. J. | pmid:27224487 |
| Traïkia M et al. | Asymmetrical membranes and surface tension. | 2002 | Biophys. J. | pmid:12202370 |
| Ariola FS et al. | Membrane fluidity and lipid order in ternary giant unilamellar vesicles using a new bodipy-cholesterol derivative. | 2009 | Biophys. J. | pmid:19348752 |
| Wang H et al. | Coherent anti-stokes Raman scattering imaging of axonal myelin in live spinal tissues. | 2005 | Biophys. J. | pmid:15834003 |
| Dalton LA and Miller KW | Trans-unsaturated lipid dynamics: modulation of dielaidoylphosphatidylcholine acyl chain motion by ethanol. | 1993 | Biophys. J. | pmid:8274650 |
| Weinberger A et al. | Gel-assisted formation of giant unilamellar vesicles. | 2013 | Biophys. J. | pmid:23823234 |
| Haque ME et al. | Properties and structures of the influenza and HIV fusion peptides on lipid membranes: implications for a role in fusion. | 2005 | Biophys. J. | pmid:16183890 |
| Chen Z et al. | Regulation of membrane-shape transitions induced by I-BAR domains. | 2015 | Biophys. J. | pmid:26200865 |
| Chavarha M et al. | Hydrophobic surfactant proteins strongly induce negative curvature. | 2015 | Biophys. J. | pmid:26153706 |
| Lei G and MacDonald RC | Lipid bilayer vesicle fusion: intermediates captured by high-speed microfluorescence spectroscopy. | 2003 | Biophys. J. | pmid:12944275 |
| Yasuda T et al. | Deuterium NMR of raft model membranes reveals domain-specific order profiles and compositional distribution. | 2015 | Biophys. J. | pmid:25992728 |
| McIntosh TJ et al. | Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. | 2003 | Biophys. J. | pmid:12944280 |
| Lin Q and London E | Ordered raft domains induced by outer leaflet sphingomyelin in cholesterol-rich asymmetric vesicles. | 2015 | Biophys. J. | pmid:25954879 |
| Szule JA and Rand RP | The effects of gramicidin on the structure of phospholipid assemblies. | 2003 | Biophys. J. | pmid:12944285 |
| Wunderlich B et al. | Phase-state dependent current fluctuations in pure lipid membranes. | 2009 | Biophys. J. | pmid:19486681 |
| Yesylevskyy S et al. | Alternative mechanisms for the interaction of the cell-penetrating peptides penetratin and the TAT peptide with lipid bilayers. | 2009 | Biophys. J. | pmid:19580742 |
| Alves ID et al. | Phosphatidylethanolamine enhances rhodopsin photoactivation and transducin binding in a solid supported lipid bilayer as determined using plasmon-waveguide resonance spectroscopy. | 2005 | Biophys. J. | pmid:15501933 |
| Siegel DP et al. | Intermediates in membrane fusion and bilayer/nonbilayer phase transitions imaged by time-resolved cryo-transmission electron microscopy. | 1989 | Biophys. J. | pmid:2752086 |
| Jo S et al. | CHARMM-GUI Membrane Builder for mixed bilayers and its application to yeast membranes. | 2009 | Biophys. J. | pmid:19580743 |
| Benz RW et al. | Experimental validation of molecular dynamics simulations of lipid bilayers: a new approach. | 2005 | Biophys. J. | pmid:15533925 |
| Kucerka N et al. | Structure of fully hydrated fluid phase DMPC and DLPC lipid bilayers using X-ray scattering from oriented multilamellar arrays and from unilamellar vesicles. | 2005 | Biophys. J. | pmid:15665131 |
| Garcia-Manyes S et al. | Effect of ion-binding and chemical phospholipid structure on the nanomechanics of lipid bilayers studied by force spectroscopy. | 2005 | Biophys. J. | pmid:15980180 |
| Chakraborty H et al. | pH Alters PEG-mediated fusion of phosphatidylethanolamine-containing vesicles. | 2014 | Biophys. J. | pmid:25229141 |
| Cornell CE et al. | n-Alcohol Length Governs Shift in L-L Mixing Temperatures in Synthetic and Cell-Derived Membranes. | 2017 | Biophys. J. | pmid:28801104 |
| Volke F et al. | Hydration force parameters of phosphatidylcholine lipid bilayers as determined from 2H-NMR studies of deuterated water. | 1994 | Biophys. J. | pmid:7858124 |
| Lee MT et al. | Molecular State of the Membrane-Active Antibiotic Daptomycin. | 2017 | Biophys. J. | pmid:28700928 |
| Ritzmann N et al. | Fusion Domains Guide the Oriented Insertion of Light-Driven Proton Pumps into Liposomes. | 2017 | Biophys. J. | pmid:28697898 |
| Fattal DR and Ben-Shaul A | Mean-field calculations of chain packing and conformational statistics in lipid bilayers: comparison with experiments and molecular dynamics studies. | 1994 | Biophys. J. | pmid:7811955 |
| Tielrooij KJ et al. | Dielectric relaxation dynamics of water in model membranes probed by terahertz spectroscopy. | 2009 | Biophys. J. | pmid:19883591 |
| Mok KW and Cullis PR | Structural and fusogenic properties of cationic liposomes in the presence of plasmid DNA. | 1997 | Biophys. J. | pmid:9370447 |
| Koklic T et al. | Factor XA binding to phosphatidylserine-containing membranes produces an inactive membrane-bound dimer. | 2009 | Biophys. J. | pmid:19843455 |
| Zhou Z et al. | 15N NMR study of the ionization properties of the influenza virus fusion peptide in zwitterionic phospholipid dispersions. | 2000 | Biophys. J. | pmid:10777737 |
| Holt A et al. | Tilt and rotation angles of a transmembrane model peptide as studied by fluorescence spectroscopy. | 2009 | Biophys. J. | pmid:19843458 |
| Yoo J and Cui Q | Curvature generation and pressure profile modulation in membrane by lysolipids: insights from coarse-grained simulations. | 2009 | Biophys. J. | pmid:19843459 |
| Hui SW et al. | The role of helper lipids in cationic liposome-mediated gene transfer. | 1996 | Biophys. J. | pmid:8842198 |
| Arkhipov A et al. | Membrane-bending mechanism of amphiphysin N-BAR domains. | 2009 | Biophys. J. | pmid:19917226 |
| Gasecka A et al. | Quantitative imaging of molecular order in lipid membranes using two-photon fluorescence polarimetry. | 2009 | Biophys. J. | pmid:19917241 |