1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gruner SM et al. | X-ray diffraction study of the polymorphic behavior of N-methylated dioleoylphosphatidylethanolamine. | 1988 | Biochemistry | pmid:3401452 |
| Benz R | Structural requirement for the rapid movement of charged molecules across membranes. Experiments with tetraphenylborate analogues. | 1988 | Biophys. J. | pmid:3416031 |
| Munkonge F et al. | Positions of the sites labeled by N-cyclohexyl-N'-(4-dimethylamino-1-naphthyl)carbodiimide on the (Ca2+ + Mg2+)-ATPase. | 1989 | Biochim. Biophys. Acta | pmid:2521797 |
| Subczynski WK et al. | Oxygen permeability of phosphatidylcholine--cholesterol membranes. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2543978 |
| Ruggiero A and Hudson B | Analysis of the anisotropy decay of trans-parinaric acid in lipid bilayers. | 1989 | Biophys. J. | pmid:2765650 |
| Meulendijks GH et al. | The different influences of ether and ester phospholipids on the conformation of gramicidin A. A molecular modelling study. | 1989 | Biochim. Biophys. Acta | pmid:2466485 |
| Scarlata SF | Evaluation of the thermal coefficient of the resistance to fluorophore rotation in model membranes. | 1989 | Biophys. J. | pmid:2765657 |
| Tate MW and Gruner SM | Temperature dependence of the structural dimensions of the inverted hexagonal (HII) phase of phosphatidylethanolamine-containing membranes. | 1989 | Biochemistry | pmid:2765485 |
| Whyte BS et al. | Amphotericin B and Nystatin show different activities on sterol-free vesicles. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2818579 |
| Pinnaduwage P and Huang L | The role of protein-linked oligosaccharide in the bilayer stabilization activity of glycophorin A for dioleoylphosphatidylethanolamine liposomes. | 1989 | Biochim. Biophys. Acta | pmid:2819088 |