1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Evans KO et al. | Octadecyl ferulate behavior in 1,2-Dioleoylphosphocholine liposomes. | 2016 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:26332862 |
| Mikhalyov I et al. | Donor-donor energy migration (DDEM) as a tool for studying aggregation in lipid phases. | 2001 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:11506035 |
| Halder A et al. | Lipid chain saturation and the cholesterol in the phospholipid membrane affect the spectroscopic properties of lipophilic dye nile red. | 2018 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:28992460 |
| Li GC et al. | Solid-state NMR analysis of steroidal conformation of 17α- and 17β-estradiol in the absence and presence of lipid environment. | 2012 | Steroids | pmid:22155023 |
| Leyrat C et al. | Structure and self-assembly of the calcium binding matrix protein of human metapneumovirus. | 2014 | Structure | pmid:24316400 |
| Du J et al. | Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding. | 2015 | Thromb. Haemost. | pmid:25354705 |
| Finlayson-Pitts BJ et al. | A Fourier transform infrared spectrometry study of the reactions of phosphatidylcholines with gaseous N2O5 and NO2. | 1987 | Toxicol. Appl. Pharmacol. | pmid:3603571 |
| Razpotnik A et al. | A new cytolytic protein from the sea anemone Urticina crassicornis that binds to cholesterol- and sphingomyelin-rich membranes. | 2009 | Toxicon | pmid:19232528 |
| Takahashi T et al. | Multiple membrane interactions and versatile vesicle deformations elicited by melittin. | 2013 | Toxins (Basel) | pmid:23594437 |
| Kooijman EE et al. | Modulation of membrane curvature by phosphatidic acid and lysophosphatidic acid. | 2003 | Traffic | pmid:12656989 |