1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wu F et al. | Stability of annexin V in ternary complexes with Ca2+ and anionic phospholipids: IR studies of monolayer and bulk phases. | 1999 | Biochemistry | pmid:9888820 |
| Pécheur EI et al. | Lipid headgroup spacing and peptide penetration, but not peptide oligomerization, modulate peptide-induced fusion. | 1999 | Biochemistry | pmid:9890918 |
| Thérond P et al. | Copper oxidation of in vitro dioleolylphosphatidylcholine-enriched high-density lipoproteins: physicochemical features and cholesterol effluxing capacity. | 1999 | Arch. Biochem. Biophys. | pmid:9917338 |
| Takei J et al. | Generalised bilayer perturbation from peptide helix dimerisation at membrane surfaces: vesicle lysis induced by disulphide-dimerised melittin analogues. | 1999 | FEBS Lett. | pmid:9923594 |
| Van Mau N et al. | Lipid-induced organization of a primary amphipathic peptide: a coupled AFM-monolayer study. | 1999 | J. Membr. Biol. | pmid:9929376 |
| Hunter GW et al. | Phosphatidylethanolamine modulates Ca-ATPase function and dynamics. | 1999 | Biochemistry | pmid:9930998 |
| Epand RF et al. | The ectodomain of HA2 of influenza virus promotes rapid pH dependent membrane fusion. | 1999 | J. Mol. Biol. | pmid:9973566 |