1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pohjala LL et al. | Interference by bovine serum albumin in PED6 based phospholipase A2 screening assays. | 2012 | Pharmazie | pmid:23210248 |
| Tsuchiya H | Effects of green tea catechins on membrane fluidity. | 1999 | Pharmacology | pmid:10352424 |
| Parker RJ et al. | Effect of liposome encapsulation of a fluorescent dye on its uptake by the lymphatics of the rat. | 1981 | Pharmacology | pmid:7280007 |
| Garcia MT et al. | Transdermal delivery of ketoprofen: the influence of drug-dioleylphosphatidylcholine interactions. | 2006 | Pharm. Res. | pmid:16858649 |
| Pierrat P et al. | Bioresponsive deciduous-charge amphiphiles for liposomal delivery of DNA and siRNA. | 2013 | Pharm. Res. | pmid:23371513 |
| Souza AC et al. | Development and characterization of multilamellar liposomes containing pyridostigmine. | 2014 | Pharm Dev Technol | pmid:23682846 |
| Abrami L et al. | Glycerol permeability of mutant aquaporin 1 and other AQP-MIP proteins: inhibition studies. | 1996 | Pflugers Arch. | pmid:8584435 |
| Saint N et al. | The antibacterial peptide ceratotoxin A displays alamethicin-like behavior in lipid bilayers. | 2003 | Peptides | pmid:15019210 |
| Notter RH et al. | Bilirubin interactions with phospholipid components of lung surfactant. | 1982 | Pediatr. Res. | pmid:6895780 |
| Dods RH et al. | The innate reactivity of a membrane associated peptide towards lipids: acyl transfer to melittin without enzyme catalysis. | 2012 | Org. Biomol. Chem. | pmid:22407502 |
| Klijn JE and Engberts JB | The Kemp elimination in membrane mimetic reaction media. Probing catalytic properties of cationic vesicles formed from a double-tailed amphiphile and linear long-tailed alcohols or alkyl pyranosides. | 2004 | Org. Biomol. Chem. | pmid:15188048 |
| Poznik M et al. | The interface makes a difference: lanthanide ion coated vesicles hydrolyze phosphodiesters. | 2015 | Org. Biomol. Chem. | pmid:26269206 |
| Bruni P et al. | Fe2+ promoted peroxidation of 1,2-diacyl-sn-glycero-3-phosphocholine liposomes in the presence of calf thymus DNA. | 2005 | Org. Biomol. Chem. | pmid:16172690 |
| Shatursky OY et al. | Anion carrier formation by calix[4]arene-bis-hydroxymethylphosphonic acid in bilayer membranes. | 2014 | Org. Biomol. Chem. | pmid:25335911 |
| You L et al. | Anion transport properties of amine and amide-sidechained peptides are affected by charge and phospholipid composition. | 2008 | Org. Biomol. Chem. | pmid:18688484 |
| Poznik M and König B | Cooperative hydrolysis of aryl esters on functionalized membrane surfaces and in micellar solutions. | 2014 | Org. Biomol. Chem. | pmid:24722623 |
| Rupaimoole R et al. | Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression. | 2016 | Oncogene | pmid:26725326 |
| Murphy EA et al. | Compaction of DNA in an anionic micelle environment followed by assembly into phosphatidylcholine liposomes. | 2000 | Nucleic Acids Res. | pmid:10908363 |
| Guilarte TR et al. | Biochemical evidence of an interaction of lead at the zinc allosteric sites of the NMDA receptor complex: effects of neuronal development. | 1995 | Neurotoxicology | pmid:7603646 |
| Rahmann H et al. | Calcium-ganglioside interactions and synaptic plasticity: effect of calcium on specific ganglioside/peptide (valinomycin, gramicidin A)-complexes in mixed mono- and bilayers. | 1992 | Neurochem. Int. | pmid:1284679 |
| Baumgart T et al. | Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension. | 2003 | Nature | pmid:14574408 |
| Stabley DR et al. | Visualizing mechanical tension across membrane receptors with a fluorescent sensor. | 2012 | Nat. Methods | pmid:22037704 |
| Larsen JB et al. | Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases. | 2015 | Nat. Chem. Biol. | pmid:25622090 |
| Hatzakis NS et al. | How curved membranes recruit amphipathic helices and protein anchoring motifs. | 2009 | Nat. Chem. Biol. | pmid:19749743 |
| Gerlach H et al. | HIV-1 Nef membrane association depends on charge, curvature, composition and sequence. | 2010 | Nat. Chem. Biol. | pmid:19935658 |
| Feigenson GW | Phase behavior of lipid mixtures. | 2006 | Nat. Chem. Biol. | pmid:17051225 |
| Hirtz M et al. | Multiplexed biomimetic lipid membranes on graphene by dip-pen nanolithography. | 2013 | Nat Commun | pmid:24107937 |
| Van Lehn RC et al. | Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes. | 2014 | Nat Commun | pmid:25042518 |
| Yang ST et al. | Line tension at lipid phase boundaries as driving force for HIV fusion peptide-mediated fusion. | 2016 | Nat Commun | pmid:27113279 |
| Wu SY et al. | A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. | 2016 | Nat Commun | pmid:27041221 |
| Moser von Filseck J et al. | A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes. | 2015 | Nat Commun | pmid:25849868 |
| Ryu YS et al. | Reconstituting ring-rafts in bud-mimicking topography of model membranes. | 2014 | Nat Commun | pmid:25058275 |
| Vanni S et al. | A sub-nanometre view of how membrane curvature and composition modulate lipid packing and protein recruitment. | 2014 | Nat Commun | pmid:25222832 |
| Liu D et al. | Peptide density targets and impedes triple negative breast cancer metastasis. | 2018 | Nat Commun | pmid:29973594 |
| Kamiya K et al. | Cell-sized asymmetric lipid vesicles facilitate the investigation of asymmetric membranes. | 2016 | Nat Chem | pmid:27554415 |
| Yang Y et al. | Self-assembly of size-controlled liposomes on DNA nanotemplates. | 2016 | Nat Chem | pmid:27102682 |
| Wang F and Liu J | Nanodiamond decorated liposomes as highly biocompatible delivery vehicles and a comparison with carbon nanotubes and graphene oxide. | 2013 | Nanoscale | pmid:24162019 |
| Dols-Perez A et al. | Nanoscale electric polarizability of ultrathin biolayers on insulating substrates by electrostatic force microscopy. | 2015 | Nanoscale | pmid:26488226 |
| Hoffmann I et al. | Softening of phospholipid membranes by the adhesion of silica nanoparticles--as seen by neutron spin-echo (NSE). | 2014 | Nanoscale | pmid:24838980 |
| Dabkowska AP et al. | Assembly of RNA nanostructures on supported lipid bilayers. | 2015 | Nanoscale | pmid:25417592 |
| Janeczek AA et al. | PEGylated liposomes associate with Wnt3A protein and expand putative stem cells in human bone marrow populations. | 2017 | Nanomedicine (Lond) | pmid:28351228 |
| Huang SC et al. | Formation, stability, and mobility of one-dimensional lipid bilayers on polysilicon nanowires. | 2007 | Nano Lett. | pmid:17900161 |
| Spillane KM et al. | High-speed single-particle tracking of GM1 in model membranes reveals anomalous diffusion due to interleaflet coupling and molecular pinning. | 2014 | Nano Lett. | pmid:25133992 |
| Yamamoto Y et al. | Synthesis of novel phospholipids that bind phenylalkanols and hydroquinone via phospholipase D-catalyzed transphosphatidylation. | 2011 | N Biotechnol | pmid:20601268 |
| Aye M et al. | Genotoxic and mutagenic effects of lipid-coated CdSe/ZnS quantum dots. | 2013 | Mutat. Res. | pmid:23147700 |
| Kohn EM et al. | Role of Cationic Side Chains in the Antimicrobial Activity of C18G. | 2018 | Molecules | pmid:29401708 |
| Wasif Baig M et al. | Orientation of Laurdan in Phospholipid Bilayers Influences Its Fluorescence: Quantum Mechanics and Classical Molecular Dynamics Study. | 2018 | Molecules | pmid:30011800 |
| Rhodes DG et al. | Equilibrium and kinetic studies of the interactions of salmeterol with membrane bilayers. | 1992 | Mol. Pharmacol. | pmid:1435738 |
| Gunawan RC and Auguste DT | Immunoliposomes that target endothelium in vitro are dependent on lipid raft formation. | 2010 | Mol. Pharm. | pmid:20666515 |
| Cao Y et al. | Development of structure-lipid bilayer permeability relationships for peptide-like small organic molecules. | 2008 May-Jun | Mol. Pharm. | pmid:18355031 |