1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kol MA et al. | Phospholipid flop induced by transmembrane peptides in model membranes is modulated by lipid composition. | 2003 | Biochemistry | pmid:12515559 |
| Veatch SL and Keller SL | A closer look at the canonical 'Raft Mixture' in model membrane studies. | 2003 | Biophys. J. | pmid:12524324 |
| Persson D et al. | Application of a novel analysis to measure the binding of the membrane-translocating peptide penetratin to negatively charged liposomes. | 2003 | Biochemistry | pmid:12525169 |
| Akiyoshi K et al. | Induction of neuron-like tubes and liposome networks by cooperative effect of gangliosides and phospholipids. | 2003 | FEBS Lett. | pmid:12527358 |
| Jiao X et al. | Modulation of cellular immune response against hepatitis C virus nonstructural protein 3 by cationic liposome encapsulated DNA immunization. | 2003 | Hepatology | pmid:12540796 |
| Pfeiffer H et al. | Hydration pressure and phase transitions of phospholipids. I. Piezotropic approach. | 2003 | Biochim. Biophys. Acta | pmid:12543374 |
| Addona GH et al. | Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site. | 2003 | Biochim. Biophys. Acta | pmid:12543379 |
| Mayer PT et al. | A hydrophobicity scale for the lipid bilayer barrier domain from peptide permeabilities: nonadditivities in residue contributions. | 2003 | Biochemistry | pmid:12578376 |
| Lindholm-Sethson B et al. | Gramicidin A interaction at a dioleoyl phosphatidylcholine monolayer on a mercury drop electrode. | 2003 | Anal Bioanal Chem | pmid:12589498 |
| Debnath D et al. | Phospholipid assisted folding of a denatured heme protein: effect of phosphatidylethanolamine. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12589809 |
| Karatekin E et al. | Cascades of transient pores in giant vesicles: line tension and transport. | 2003 | Biophys. J. | pmid:12609875 |
| Lawrence JC et al. | Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy. | 2003 | Biophys. J. | pmid:12609884 |
| Fradin C et al. | Fluorescence correlation spectroscopy close to a fluctuating membrane. | 2003 | Biophys. J. | pmid:12609903 |
| Go ML and Li QT | Interaction of the antimalarial agents halofantrine and lumefantrine with lipid bilayers. | 2003 | Chem. Pharm. Bull. | pmid:12612404 |
| Francescangeli O et al. | Structure of self-assembled liposome-DNA-metal complexes. | 2003 | Phys Rev E Stat Nonlin Soft Matter Phys | pmid:12636529 |
| Becucci L et al. | Pore formation by 6-ketocholestanol in phospholipid monolayers and its interpretation by a general nucleation-and-growth model accounting for the sigmoidal shape of voltage-clamp curves of ion channels. | 2003 | J. Am. Chem. Soc. | pmid:12656611 |
| Kooijman EE et al. | Modulation of membrane curvature by phosphatidic acid and lysophosphatidic acid. | 2003 | Traffic | pmid:12656989 |
| UhrÃková D et al. | Small-angle neutron scattering study of the lipid bilayer thickness in unilamellar dioleoylphosphatidylcholine vesicles prepared by the cholate dilution method: n-decane effect. | 2003 | Biochim. Biophys. Acta | pmid:12659942 |
| Puech PH et al. | Line thermodynamics: adsorption at a membrane edge. | 2003 | Phys. Rev. Lett. | pmid:12688911 |
| Hianik T et al. | Hybridization of DNA at the surface of phospholipid monolayers. Effect of orientation of oligonucleotide chains. | 2003 | Bioelectrochemistry | pmid:12699817 |
| Filippov A et al. | The effect of cholesterol on the lateral diffusion of phospholipids in oriented bilayers. | 2003 | Biophys. J. | pmid:12719238 |
| Yang L et al. | New phases of phospholipids and implications to the membrane fusion problem. | 2003 | Biochemistry | pmid:12779317 |
| Tieleman DP et al. | Simulation of pore formation in lipid bilayers by mechanical stress and electric fields. | 2003 | J. Am. Chem. Soc. | pmid:12785774 |
| Rahmann H et al. | Calcium-ganglioside interactions and synaptic plasticity: effect of calcium on specific ganglioside/peptide (valinomycin, gramicidin A)-complexes in mixed mono- and bilayers. | 1992 | Neurochem. Int. | pmid:1284679 |
| van Duyl BY et al. | Sphingomyelin is much more effective than saturated phosphatidylcholine in excluding unsaturated phosphatidylcholine from domains formed with cholesterol. | 2003 | FEBS Lett. | pmid:12860394 |
| Ramprasad MP et al. | The sustained granulopoietic effect of progenipoietin encapsulated in multivesicular liposomes. | 2003 | Int J Pharm | pmid:12878398 |
| Pons T et al. | Mechanisms of membrane potential sensing with second-harmonic generation microscopy. | 2003 | J Biomed Opt | pmid:12880348 |
| Aliste MP et al. | Molecular dynamics simulations of pentapeptides at interfaces: salt bridge and cation-pi interactions. | 2003 | Biochemistry | pmid:12885230 |
| Silvius JR | Fluorescence energy transfer reveals microdomain formation at physiological temperatures in lipid mixtures modeling the outer leaflet of the plasma membrane. | 2003 | Biophys. J. | pmid:12885650 |
| Maaloum M | A close encounter with DNA. | 2003 | Eur. Biophys. J. | pmid:12908089 |
| Lei G and MacDonald RC | Lipid bilayer vesicle fusion: intermediates captured by high-speed microfluorescence spectroscopy. | 2003 | Biophys. J. | pmid:12944275 |
| McIntosh TJ et al. | Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. | 2003 | Biophys. J. | pmid:12944280 |
| Szule JA and Rand RP | The effects of gramicidin on the structure of phospholipid assemblies. | 2003 | Biophys. J. | pmid:12944285 |
| Epand RF et al. | Specificity of membrane binding of the neuronal protein NAP-22. | 2003 | J. Membr. Biol. | pmid:12962277 |
| Clark EH et al. | The role of tryptophan residues in an integral membrane protein: diacylglycerol kinase. | 2003 | Biochemistry | pmid:12974643 |
| Keller RC et al. | Anionic phospholipids are essential for alpha-helix formation of the signal peptide of prePhoE upon interaction with phospholipid vesicles. | 1992 | Biochemistry | pmid:1310616 |
| Naubatova MK et al. | [Lipolysis in model membranes in the presence of positively charged soluble proteins]. | 1992 | Biokhimiia | pmid:1322192 |
| Nicholls P et al. | Probe and protein orientations in proteoliposomes: electron microscopy and topobiochemistry. | 1992 | Biochem. Soc. Trans. | pmid:1327894 |
| Subczynski WK et al. | Oxygen diffusion-concentration product in rhodopsin as observed by a pulse ESR spin labeling method. | 1992 | Biophys. J. | pmid:1330032 |
| Sanders JC et al. | A small protein in model membranes: a time-resolved fluorescence and ESR study on the interaction of M13 coat protein with lipid bilayers. | 1992 | Eur. Biophys. J. | pmid:1336450 |
| Janz S et al. | The fluidity of DOPC bilayers and membrane fractions prepared from murine plasmacytoma cells is unchanged after incorporation of pristane (2,6,10,14-tetramethylpentadecane) as assessed by fluorescence polarization analysis. | 1992 | Cancer Biochem. Biophys. | pmid:1343851 |
| ALLEN RH and TONKS DB | Pure phosphatides and the serodiagnosis of syphilis: relation of chemical structure to reactivity. | 1958 | Bull. World Health Organ. | pmid:13596881 |
| Schagina LV et al. | Sterol specific inactivation of gramicidin A induced membrane cation permeability. | 1992 | Biochim. Biophys. Acta | pmid:1380301 |
| de Wolf FA et al. | Effect of doxorubicin on the order of the acyl chains of anionic and zwitterionic phospholipids in liquid-crystalline mixed model membranes: absence of drug-induced segregation of lipids into extended domains. | 1992 | Biochemistry | pmid:1390711 |
| Tilcock C et al. | Nuclear magnetic relaxation dispersion and 31P-NMR studies of the effect of covalent modification of membrane surfaces with poly(ethylene glycol). | 1992 | Biochim. Biophys. Acta | pmid:1390847 |
| Sanders JC et al. | Formation of non-bilayer structures induced by M13 coat protein depends on the conformation of the protein. | 1992 | Biochim. Biophys. Acta | pmid:1390851 |
| Duff KC et al. | The secondary structure of influenza A M2 transmembrane domain. A circular dichroism study. | 1992 | FEBS Lett. | pmid:1397324 |
| Mindham MA and Mayes PA | Removal of cholesterol from the rat spleen by phospholipid-apolipoprotein mixtures. | 1992 | Biochem. Soc. Trans. | pmid:1397515 |
| Tsuchiya M et al. | Antioxidant radical-scavenging activity of carotenoids and retinoids compared to alpha-tocopherol. | 1992 | Meth. Enzymol. | pmid:1435314 |
| Rhodes DG et al. | Equilibrium and kinetic studies of the interactions of salmeterol with membrane bilayers. | 1992 | Mol. Pharmacol. | pmid:1435738 |