1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Resseguie WD and Hughes BL | Catabolism of phospholipids by chicken seminal components after storage. | 1984 | Poult. Sci. | pmid:6483728 |
| Stein Y et al. | Metabolism of liposomes prepared from a labelled ether analog of 1,2-dioleoyl-sn-glycero-3-phosphocholine in the rat. | 1984 | Biochim. Biophys. Acta | pmid:6712973 |
| Chong PL and Cossins AR | Interacting effects of temperature, pressure and cholesterol content upon the molecular order of dioleoylphosphatidylcholine vesicles. | 1984 | Biochim. Biophys. Acta | pmid:6722144 |
| Madden TD and Cullis PR | Detergent-induced solubilization of cytochrome c oxidase as detected in a novel reconstituted system. | 1984 | J. Biol. Chem. | pmid:6330068 |
| Gambale F et al. | GM1 micelles modify the transport properties of the ionophore gramicidin D in artificial planar bilayers. | 1984 | J. Neurosci. Res. | pmid:6209414 |
| Killian JA et al. | The tryptophans of gramicidin are essential for the lipid structure modulating effect of the peptide. | 1985 | Biochim. Biophys. Acta | pmid:2413889 |
| Killian JA and de Kruijff B | Importance of hydration for gramicidin-induced hexagonal HII phase formation in dioleoylphosphatidylcholine model membranes. | 1985 | Biochemistry | pmid:2418875 |
| Apell HJ et al. | Optical study of active ion transport in lipid vesicles containing reconstituted Na,K-ATPase. | 1985 | J. Membr. Biol. | pmid:2991528 |
| East JM et al. | Exchange rates and numbers of annular lipids for the calcium and magnesium ion dependent adenosinetriphosphatase. | 1985 | Biochemistry | pmid:2992571 |
| Limbacher HP et al. | Multiequilibrium binding of a spin-labeled local anesthetic in phosphatidylcholine bilayers. | 1985 | Biochim. Biophys. Acta | pmid:2981545 |