1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| McCarthy MP and Moore MA | Effects of lipids and detergents on the conformation of the nicotinic acetylcholine receptor from Torpedo californica. | 1992 | J. Biol. Chem. | pmid:1560000 |
| Chen SG et al. | Phosphatidylcholine-dependent protein kinase C activation. Effects of cis-fatty acid and diacylglycerol on synergism, autophosphorylation and Ca(2+)-dependency. | 1992 | Biochem. J. | pmid:1599399 |
| Janz S et al. | The fluidity of DOPC bilayers and membrane fractions prepared from murine plasmacytoma cells is unchanged after incorporation of pristane (2,6,10,14-tetramethylpentadecane) as assessed by fluorescence polarization analysis. | 1992 | Cancer Biochem. Biophys. | pmid:1343851 |
| Nicholls P et al. | Probe and protein orientations in proteoliposomes: electron microscopy and topobiochemistry. | 1992 | Biochem. Soc. Trans. | pmid:1327894 |
| Rahmann H et al. | Calcium-ganglioside interactions and synaptic plasticity: effect of calcium on specific ganglioside/peptide (valinomycin, gramicidin A)-complexes in mixed mono- and bilayers. | 1992 | Neurochem. Int. | pmid:1284679 |
| Keller RC et al. | Anionic phospholipids are essential for alpha-helix formation of the signal peptide of prePhoE upon interaction with phospholipid vesicles. | 1992 | Biochemistry | pmid:1310616 |
| Naubatova MK et al. | [Lipolysis in model membranes in the presence of positively charged soluble proteins]. | 1992 | Biokhimiia | pmid:1322192 |
| Sanders JC et al. | A small protein in model membranes: a time-resolved fluorescence and ESR study on the interaction of M13 coat protein with lipid bilayers. | 1992 | Eur. Biophys. J. | pmid:1336450 |
| Schagina LV et al. | Sterol specific inactivation of gramicidin A induced membrane cation permeability. | 1992 | Biochim. Biophys. Acta | pmid:1380301 |
| Backlund BM and Gräslund A | Structure and dynamics of motilin. Time-resolved fluorescence of peptide hormone with single tyrosine residue. | 1992 | Biophys. Chem. | pmid:1467441 |
| Simon SA et al. | Modulation of the interbilayer hydration pressure by the addition of dipoles at the hydrocarbon/water interface. | 1992 | Biophys. J. | pmid:1504249 |
| de Wolf FA et al. | Effect of doxorubicin on the order of the acyl chains of anionic and zwitterionic phospholipids in liquid-crystalline mixed model membranes: absence of drug-induced segregation of lipids into extended domains. | 1992 | Biochemistry | pmid:1390711 |
| Tilcock C et al. | Nuclear magnetic relaxation dispersion and 31P-NMR studies of the effect of covalent modification of membrane surfaces with poly(ethylene glycol). | 1992 | Biochim. Biophys. Acta | pmid:1390847 |
| Habiger RG et al. | Influence of stigmastanol and stigmastanyl-phosphorylcholine, two plasma cholesterol lowering substances, on synthetic phospholipid membranes. A 2H- and 31P-NMR study. | 1992 | Biochim. Biophys. Acta | pmid:1730022 |
| In 't Veld G et al. | Acidic phospholipids are required during solubilization of amino acid transport systems of Lactococcus lactis. | 1992 | Biochim. Biophys. Acta | pmid:1547262 |
| Riley DE and Krieger JN | Rapid and practical DNA isolation from Trichomonas vaginalis and other nuclease-rich protozoa. | 1992 | Mol. Biochem. Parasitol. | pmid:1565132 |
| Chen SY et al. | Quantitation of lateral stress in lipid layer containing nonbilayer phase preferring lipids by frequency-domain fluorescence spectroscopy. | 1992 | Biochemistry | pmid:1567830 |
| Noy N et al. | The kinetics of interactions of bilirubin with lipid bilayers and with serum albumin. | 1992 | Biophys. Chem. | pmid:1567989 |
| Demel RA et al. | Insect apolipophorin III: interaction of locust apolipophorin III with diacylglycerol. | 1992 | Biochim. Biophys. Acta | pmid:1543737 |
| Teng Q and Scarlata S | Effect of high pressure on the association of melittin to membranes. | 1993 | J. Biol. Chem. | pmid:8509383 |
| Woolley GA and Wallace BA | Temperature dependence of the interaction of alamethicin helices in membranes. | 1993 | Biochemistry | pmid:7690593 |
| Tortorella D et al. | Simple centrifugation method for efficient pelleting of both small and large unilamellar vesicles that allows convenient measurement of protein binding. | 1993 | Biochemistry | pmid:8369285 |
| Keller SL et al. | Probability of alamethicin conductance states varies with nonlamellar tendency of bilayer phospholipids. | 1993 | Biophys. J. | pmid:8369434 |
| Sarmento AB et al. | Partition of dopamine antagonists into synthetic lipid bilayers: the effect of membrane structure and composition. | 1993 | J. Pharm. Pharmacol. | pmid:8105052 |
| Eriksson PO and Lindblom G | Lipid and water diffusion in bicontinuous cubic phases measured by NMR. | 1993 | Biophys. J. | pmid:8431537 |
| Wessels JM et al. | Photodegradation of protoporphyrin-dimethylester in solution and in organized environments. | 1993 | Int. J. Radiat. Biol. | pmid:7902387 |
| Nag K and Keough KM | Epifluorescence microscopic studies of monolayers containing mixtures of dioleoyl- and dipalmitoylphosphatidylcholines. | 1993 | Biophys. J. | pmid:8241382 |
| Abadji VC et al. | The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles. | 1993 | Biochim. Biophys. Acta | pmid:8466926 |
| Leenhouts JM et al. | The membrane potential has no detectable effect on the phosphocholine headgroup conformation in large unilamellar phosphatidylcholine vesicles as determined by 2H-NMR. | 1993 | Biochim. Biophys. Acta | pmid:8274495 |
| Siegel DP | Energetics of intermediates in membrane fusion: comparison of stalk and inverted micellar intermediate mechanisms. | 1993 | Biophys. J. | pmid:8298039 |
| Johansson LB et al. | Phase equilibria and formation of vesicles of dioleoylphosphatidylcholine in glycerol/water mixtures. | 1993 | Biochim. Biophys. Acta | pmid:8391842 |
| Freisleben HJ and Packer L | Free-radical scavenging activities, interactions and recycling of antioxidants. | 1993 | Biochem. Soc. Trans. | pmid:8395425 |
| Abrams FS and London E | Extension of the parallax analysis of membrane penetration depth to the polar region of model membranes: use of fluorescence quenching by a spin-label attached to the phospholipid polar headgroup. | 1993 | Biochemistry | pmid:8399232 |
| Ottaviani MF et al. | The macroscopic organization of reconstituted M13 coat protein-phospholipid systems. An EPR spectroscopy and polarizing microscope study. | 1993 | Biochim. Biophys. Acta | pmid:8399296 |
| Murata M et al. | Fusion of dioleoylphosphatidylcholine vesicles induced by an amphiphilic cationic peptide and oligophosphates at neutral pH. | 1993 | Biochim. Biophys. Acta | pmid:8399311 |
| Schwarz G and Blochmann U | Association of the wasp venom peptide mastoparan with electrically neutral lipid vesicles. Salt effects on partitioning and conformational state. | 1993 | FEBS Lett. | pmid:8440373 |
| Sitaram N and Nagaraj R | Interaction of the 47-residue antibacterial peptide seminalplasmin and its 13-residue fragment which has antibacterial and hemolytic activities with model membranes. | 1993 | Biochemistry | pmid:8457573 |
| Kagiwada S et al. | In vitro fusion of rabbit liver Golgi membranes with liposomes. | 1993 | J. Biol. Chem. | pmid:8419344 |
| Duff KC et al. | The location of amantadine hydrochloride and free base within phospholipid multilayers: a neutron and X-ray diffraction study. | 1993 | Biochim. Biophys. Acta | pmid:8422405 |
| Webb MS et al. | Dehydration-induced lamellar-to-hexagonal-II phase transitions in DOPE/DOPC mixtures. | 1993 | Biochim. Biophys. Acta | pmid:8422415 |
| Breukink E et al. | Nucleotide and negatively charged lipid-dependent vesicle aggregation caused by SecA. Evidence that SecA contains two lipid-binding sites. | 1993 | FEBS Lett. | pmid:8405403 |
| ter Beest MB and Hoekstra D | Interaction of myelin basic protein with artificial membranes. Parameters governing binding, aggregation and dissociation. | 1993 | Eur. J. Biochem. | pmid:7679637 |
| Murata M et al. | Specificity of amphiphilic anionic peptides for fusion of phospholipid vesicles. | 1993 | Biophys. J. | pmid:8471724 |
| Tanfani F et al. | The interaction of phospholipid bilayers with pig heart AMP deaminase: Fourier-transform infrared spectroscopic and kinetic studies. | 1993 | Biochem. J. | pmid:8489518 |
| Hirakata A et al. | Effect of protein kinase C inhibitors and activators on corneal re-epithelialization in the rat. | 1993 | Invest. Ophthalmol. Vis. Sci. | pmid:8425827 |
| Chattopadhyay A and Mukherjee S | Fluorophore environments in membrane-bound probes: a red edge excitation shift study. | 1993 | Biochemistry | pmid:8466919 |
| Dalton LA and Miller KW | Trans-unsaturated lipid dynamics: modulation of dielaidoylphosphatidylcholine acyl chain motion by ethanol. | 1993 | Biophys. J. | pmid:8274650 |
| Rand RP and Fang Y | Structure and energetics of phospholipid and diacylglycerol assemblies relative to membrane fusion. | 1993 | Biochem. Soc. Trans. | pmid:8359478 |
| Beck A et al. | Influence of the length of the spacer on the partitioning properties of amphiphilic fluorescent membrane probes. | 1993 | Chem. Phys. Lipids | pmid:8118914 |
| Nok AJ et al. | Phospholipase A2 from Trypanosoma congolense: characterization and haematological properties. | 1993 | Cell Biochem. Funct. | pmid:8324881 |