1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is a lipid of Glycerophospholipids (GP) class. 1,2-dioleoyl-sn-glycero-3-phosphocholine is associated with abnormalities such as Exanthema, Renal tubular disorder, Nodule, Gigantism and Mycoses. The involved functions are known as Lysis, Encapsulation, Process, Uptake and Flow or discharge. 1,2-dioleoyl-sn-glycero-3-phosphocholine often locates in Cytoplasmic matrix, Endosomes, soluble, Endoplasmic Reticulum and Membrane. The associated genes with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine are P4HTM gene, synthetic peptide, BCAR1 gene, PCNA gene and CNTNAP1 gene. The related lipids are Liposomes, 1,2-oleoylphosphatidylcholine, 1,2-distearoylphosphatidylethanolamine, Butanols and Cardiolipins. The related experimental models are Mouse Model and Xenograft Model.
To understand associated biological information of 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
1,2-Dioleoyl-sn-Glycero-3-Phosphocholine is suspected in Gigantism, Nodule, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Exanthema, Renal tubular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 1,2-Dioleoyl-sn-Glycero-3-Phosphocholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Ovarian Neoplasms | D010051 | 10 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Celiac Disease | D002446 | 16 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Xenograft Model are used in the study 'Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis.' (Chakravarty D et al., 2011).
Mouse Model are used in the study 'Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery.' (Landen CN et al., 2005).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Beattie ME et al. | Sterol structure determines miscibility versus melting transitions in lipid vesicles. | 2005 | Biophys. J. | pmid:15951379 |
| van Lengerich B et al. | Individual vesicle fusion events mediated by lipid-anchored DNA. | 2013 | Biophys. J. | pmid:23870262 |
| Yan W et al. | The collapse of monolayers containing pulmonary surfactant phospholipids is kinetically determined. | 2005 | Biophys. J. | pmid:15985424 |
| Marsh D | Intrinsic curvature in normal and inverted lipid structures and in membranes. | 1996 | Biophys. J. | pmid:9172748 |
| Heuvingh J and Bonneau S | Asymmetric oxidation of giant vesicles triggers curvature-associated shape transition and permeabilization. | 2009 | Biophys. J. | pmid:19948119 |
| Cheng KH and Somerharju P | Effects of unsaturation and curvature on the transverse distribution of intramolecular dynamics of dipyrenyl lipids. | 1996 | Biophys. J. | pmid:9172752 |
| Herce HD et al. | Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell-penetrating peptides. | 2009 | Biophys. J. | pmid:19804722 |
| Albersdörfer A et al. | Adhesion-induced domain formation by interplay of long-range repulsion and short-range attraction force: a model membrane study. | 1997 | Biophys. J. | pmid:9199789 |
| Chiantia S et al. | Effects of ceramide on liquid-ordered domains investigated by simultaneous AFM and FCS. | 2006 | Biophys. J. | pmid:16565041 |
| Mi LZ et al. | Interaction of rabbit C-reactive protein with phospholipid monolayers studied by microfluorescence film balance with an externally applied electric field. | 1997 | Biophys. J. | pmid:9199807 |
| Bradshaw JP | Phosphatydylglycerol promotes bilayer insertion of salmon calcitonin. | 1997 | Biophys. J. | pmid:9129820 |
| Raines DE and Miller KW | The role of charge in lipid selectivity for the nicotinic acetylcholine receptor. | 1993 | Biophys. J. | pmid:8386010 |
| Subczynski WK et al. | Oxygen diffusion-concentration product in rhodopsin as observed by a pulse ESR spin labeling method. | 1992 | Biophys. J. | pmid:1330032 |
| Filippov A et al. | The effect of cholesterol on the lateral diffusion of phospholipids in oriented bilayers. | 2003 | Biophys. J. | pmid:12719238 |
| Salesse C et al. | Direct evidence for the formation of a monolayer from a bilayer. An ellipsometric study at the nitrogen-water interface. | 1987 | Biophys. J. | pmid:3663839 |
| Raghuraman H and Chattopadhyay A | Orientation and dynamics of melittin in membranes of varying composition utilizing NBD fluorescence. | 2007 | Biophys. J. | pmid:17114219 |
| Nazarov PV et al. | FRET study of membrane proteins: determination of the tilt and orientation of the N-terminal domain of M13 major coat protein. | 2007 | Biophys. J. | pmid:17114224 |
| Glassinger E and Raphael RM | Influence of thermally driven surface undulations on tethers formed from bilayer membranes. | 2006 | Biophys. J. | pmid:16648163 |
| Scherfeld D et al. | Lipid dynamics and domain formation in model membranes composed of ternary mixtures of unsaturated and saturated phosphatidylcholines and cholesterol. | 2003 | Biophys. J. | pmid:14645066 |
| Victorov AV et al. | Packing constraints and electrostatic surface potentials determine transmembrane asymmetry of phosphatidylethanol. | 1997 | Biophys. J. | pmid:9168034 |
| Alvis SJ et al. | Interactions of anionic phospholipids and phosphatidylethanolamine with the potassium channel KcsA. | 2003 | Biophys. J. | pmid:14645072 |
| Ge M and Freed JH | Hydration, structure, and molecular interactions in the headgroup region of dioleoylphosphatidylcholine bilayers: an electron spin resonance study. | 2003 | Biophys. J. | pmid:14645091 |
| Zawisza I et al. | Electrochemical and photon polarization modulation infrared reflection absorption spectroscopy study of the electric field driven transformations of a phospholipid bilayer supported at a gold electrode surface. | 2003 | Biophys. J. | pmid:14645094 |
| Nazarov PV et al. | FRET study of membrane proteins: simulation-based fitting for analysis of membrane protein embedment and association. | 2006 | Biophys. J. | pmid:16632512 |
| Richter R et al. | Pathways of lipid vesicle deposition on solid surfaces: a combined QCM-D and AFM study. | 2003 | Biophys. J. | pmid:14581204 |
| Veatch SL and Keller SL | Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol. | 2003 | Biophys. J. | pmid:14581208 |
| Holland GP et al. | Distinguishing individual lipid headgroup mobility and phase transitions in raft-forming lipid mixtures with 31P MAS NMR. | 2006 | Biophys. J. | pmid:16533851 |
| Marrink SJ and Mark AE | Molecular view of hexagonal phase formation in phospholipid membranes. | 2004 | Biophys. J. | pmid:15377528 |
| Pandit SA et al. | Simulation of the early stages of nano-domain formation in mixed bilayers of sphingomyelin, cholesterol, and dioleylphosphatidylcholine. | 2004 | Biophys. J. | pmid:15339797 |
| MacCallum JL et al. | Transfer of arginine into lipid bilayers is nonadditive. | 2011 | Biophys. J. | pmid:21723820 |
| Becucci L et al. | Gel-phase microdomains and lipid rafts in monolayers affect the redox properties of ubiquinone-10. | 2011 | Biophys. J. | pmid:21723823 |
| Filippov A et al. | Lipid lateral diffusion in ordered and disordered phases in raft mixtures. | 2004 | Biophys. J. | pmid:14747324 |
| Eriksson PO and Lindblom G | Lipid and water diffusion in bicontinuous cubic phases measured by NMR. | 1993 | Biophys. J. | pmid:8431537 |
| Bradshaw JP et al. | Interaction of substance P with phospholipid bilayers: A neutron diffraction study. | 1998 | Biophys. J. | pmid:9675189 |
| Sun Y et al. | Adhesion and merging of lipid bilayers: a method for measuring the free energy of adhesion and hemifusion. | 2011 | Biophys. J. | pmid:21320443 |
| Gulik A et al. | A conformation transition of lung surfactant lipids probably involved in respiration. | 1994 | Biophys. J. | pmid:7811921 |
| Tristram-Nagle S et al. | Structure and interactions of fully hydrated dioleoylphosphatidylcholine bilayers. | 1998 | Biophys. J. | pmid:9675192 |
| Contino PB et al. | Use of an oriented transmembrane protein to probe the assembly of a supported phospholipid bilayer. | 1994 | Biophys. J. | pmid:7811922 |
| Harvie P et al. | Characterization of lipid DNA interactions. I. Destabilization of bound lipids and DNA dissociation. | 1998 | Biophys. J. | pmid:9675205 |
| Raghuraman H and Chattopadhyay A | Interaction of melittin with membrane cholesterol: a fluorescence approach. | 2004 | Biophys. J. | pmid:15454440 |
| Hristova K and White SH | Determination of the hydrocarbon core structure of fluid dioleoylphosphocholine (DOPC) bilayers by x-ray diffraction using specific bromination of the double-bonds: effect of hydration. | 1998 | Biophys. J. | pmid:9591668 |
| Kürschner M et al. | Interaction of lipophilic ions with the plasma membrane of mammalian cells studies by electrorotation. | 1998 | Biophys. J. | pmid:9635758 |
| de Almeida RF et al. | Complexity of lipid domains and rafts in giant unilamellar vesicles revealed by combining imaging and microscopic and macroscopic time-resolved fluorescence. | 2007 | Biophys. J. | pmid:17449668 |
| Lehtonen JY and Kinnunen PK | Changes in the lipid dynamics of liposomal membranes induced by poly(ethylene glycol): free volume alterations revealed by inter- and intramolecular excimer-forming phospholipid analogs. | 1994 | Biophys. J. | pmid:8075332 |
| Nag K and Keough KM | Epifluorescence microscopic studies of monolayers containing mixtures of dioleoyl- and dipalmitoylphosphatidylcholines. | 1993 | Biophys. J. | pmid:8241382 |
| Mihailescu M et al. | Acyl-chain methyl distributions of liquid-ordered and -disordered membranes. | 2011 | Biophys. J. | pmid:21402027 |
| Siegel DP et al. | The mechanism of lamellar-to-inverted hexagonal phase transitions: a study using temperature-jump cryo-electron microscopy. | 1994 | Biophys. J. | pmid:8161694 |
| Siegel DP | Energetics of intermediates in membrane fusion: comparison of stalk and inverted micellar intermediate mechanisms. | 1993 | Biophys. J. | pmid:8298039 |
| Snitsarev V et al. | Fluorescent detection of Zn(2+)-rich vesicles with Zinquin: mechanism of action in lipid environments. | 2001 | Biophys. J. | pmid:11222314 |
| Murail S et al. | Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor. | 2011 | Biophys. J. | pmid:21463577 |
| Le Saux A et al. | Membrane molecule reorientation in an electric field recorded by attenuated total reflection Fourier-transform infrared spectroscopy. | 2001 | Biophys. J. | pmid:11159405 |
| Hristova K et al. | Structure, location, and lipid perturbations of melittin at the membrane interface. | 2001 | Biophys. J. | pmid:11159447 |
| Mashl RJ et al. | Molecular simulation of dioleoylphosphatidylcholine lipid bilayers at differing levels of hydration. | 2001 | Biophys. J. | pmid:11720971 |
| Pan J et al. | Temperature dependence of structure, bending rigidity, and bilayer interactions of dioleoylphosphatidylcholine bilayers. | 2008 | Biophys. J. | pmid:17827241 |
| Giocondi MC et al. | Use of cyclodextrin for AFM monitoring of model raft formation. | 2004 | Biophys. J. | pmid:14747321 |
| Davis JH et al. | Phase equilibria in DOPC/DPPC-d62/cholesterol mixtures. | 2009 | Biophys. J. | pmid:19167302 |
| Dempsey CE and Handcock LJ | Hydrogen bond stabilities in membrane-reconstituted alamethicin from amide-resolved hydrogen-exchange measurements. | 1996 | Biophys. J. | pmid:8785337 |
| Baoukina S et al. | Molecular structure of membrane tethers. | 2012 | Biophys. J. | pmid:22768942 |
| Moncelli MR et al. | Electrochemical modeling of electron and proton transfer to ubiquinone-10 in a self-assembled phospholipid monolayer. | 1996 | Biophys. J. | pmid:8744309 |
| Oreopoulos J and Yip CM | Probing membrane order and topography in supported lipid bilayers by combined polarized total internal reflection fluorescence-atomic force microscopy. | 2009 | Biophys. J. | pmid:19254557 |
| Mui BL et al. | Influence of transbilayer area asymmetry on the morphology of large unilamellar vesicles. | 1995 | Biophys. J. | pmid:8519993 |
| Wiener MC and White SH | Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. II. Distribution and packing of terminal methyl groups. | 1992 | Biophys. J. | pmid:1547330 |
| Wiener MC and White SH | Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. III. Complete structure. | 1992 | Biophys. J. | pmid:1547331 |
| Murata M et al. | Specificity of amphiphilic anionic peptides for fusion of phospholipid vesicles. | 1993 | Biophys. J. | pmid:8471724 |
| Gordeliy VI and Kiselev MA | Definition of lipid membrane structural parameters from neutronographic experiments with the help of the strip function model. | 1995 | Biophys. J. | pmid:8534812 |
| Konyakhina TM et al. | Control of a nanoscopic-to-macroscopic transition: modulated phases in four-component DSPC/DOPC/POPC/Chol giant unilamellar vesicles. | 2011 | Biophys. J. | pmid:21767476 |
| Szule JA et al. | The effects of acyl chain length and saturation of diacylglycerols and phosphatidylcholines on membrane monolayer curvature. | 2002 | Biophys. J. | pmid:12124279 |
| Ruggiero A and Hudson B | Analysis of the anisotropy decay of trans-parinaric acid in lipid bilayers. | 1989 | Biophys. J. | pmid:2765650 |
| Traïkia M et al. | Asymmetrical membranes and surface tension. | 2002 | Biophys. J. | pmid:12202370 |
| van der Wel PC et al. | Geometry and intrinsic tilt of a tryptophan-anchored transmembrane alpha-helix determined by (2)H NMR. | 2002 | Biophys. J. | pmid:12202373 |
| Scarlata SF | Compression of lipid membranes as observed at varying membrane positions. | 1991 | Biophys. J. | pmid:1912276 |
| Dalton LA and Miller KW | Trans-unsaturated lipid dynamics: modulation of dielaidoylphosphatidylcholine acyl chain motion by ethanol. | 1993 | Biophys. J. | pmid:8274650 |
| Weinberger A et al. | Gel-assisted formation of giant unilamellar vesicles. | 2013 | Biophys. J. | pmid:23823234 |
| Petkova V et al. | How to control the molecular architecture of a monolayer of proteins supported by a lipid bilayer. | 2002 | Biophys. J. | pmid:11751341 |
| Goll J et al. | Photon correlation spectroscopic study of the size distribution of phospholipid vesicles. | 1982 | Biophys. J. | pmid:7074200 |
| Dietrich C et al. | Lipid rafts reconstituted in model membranes. | 2001 | Biophys. J. | pmid:11222302 |
| Salamon Z and Tollin G | Optical anisotropy in lipid bilayer membranes: coupled plasmon-waveguide resonance measurements of molecular orientation, polarizability, and shape. | 2001 | Biophys. J. | pmid:11222316 |
| Van Mau N et al. | Mixed monolayers of linear gramicidins and phospholipid. Surface pressure and surface potential studies. | 1988 | Biophys. J. | pmid:2462931 |
| Lei G and MacDonald RC | Lipid bilayer vesicle fusion: intermediates captured by high-speed microfluorescence spectroscopy. | 2003 | Biophys. J. | pmid:12944275 |
| Yasuda T et al. | Deuterium NMR of raft model membranes reveals domain-specific order profiles and compositional distribution. | 2015 | Biophys. J. | pmid:25992728 |
| McIntosh TJ et al. | Sorting of lipids and transmembrane peptides between detergent-soluble bilayers and detergent-resistant rafts. | 2003 | Biophys. J. | pmid:12944280 |
| Lin Q and London E | Ordered raft domains induced by outer leaflet sphingomyelin in cholesterol-rich asymmetric vesicles. | 2015 | Biophys. J. | pmid:25954879 |
| Szule JA and Rand RP | The effects of gramicidin on the structure of phospholipid assemblies. | 2003 | Biophys. J. | pmid:12944285 |
| Iben IE et al. | Gd3+ vibronic side band spectroscopy. New optical probe of Ca2+ binding sites applied to biological macromolecules. | 1991 | Biophys. J. | pmid:1907866 |
| Gay A et al. | Switch-like responses of two cholesterol sensors do not require protein oligomerization in membranes. | 2015 | Biophys. J. | pmid:25809258 |
| Scarlata SF | Evaluation of the thermal coefficient of the resistance to fluorophore rotation in model membranes. | 1989 | Biophys. J. | pmid:2765657 |
| Wiener MC et al. | Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. I. Scaling of neutron data and the distributions of double bonds and water. | 1991 | Biophys. J. | pmid:1932548 |
| Heberle FA et al. | Comparison of three ternary lipid bilayer mixtures: FRET and ESR reveal nanodomains. | 2010 | Biophys. J. | pmid:21081079 |
| Benz RW et al. | Experimental validation of molecular dynamics simulations of lipid bilayers: a new approach. | 2005 | Biophys. J. | pmid:15533925 |
| Dolan EA et al. | Simulations of membranes and other interfacial systems using P2(1) and Pc periodic boundary conditions. | 2002 | Biophys. J. | pmid:11964222 |
| Stottrup BL et al. | Miscibility of ternary mixtures of phospholipids and cholesterol in monolayers, and application to bilayer systems. | 2005 | Biophys. J. | pmid:15475588 |
| Stefl M et al. | Simultaneous characterization of lateral lipid and prothrombin diffusion coefficients by z-scan fluorescence correlation spectroscopy. | 2009 | Biophys. J. | pmid:19651025 |
| Richter RP et al. | On the kinetics of adsorption and two-dimensional self-assembly of annexin A5 on supported lipid bilayers. | 2005 | Biophys. J. | pmid:16085777 |
| Chakraborty H et al. | pH Alters PEG-mediated fusion of phosphatidylethanolamine-containing vesicles. | 2014 | Biophys. J. | pmid:25229141 |
| McConnell H | Complexes in ternary cholesterol-phospholipid mixtures. | 2005 | Biophys. J. | pmid:15695625 |
| Baoukina S et al. | The mechanism of collapse of heterogeneous lipid monolayers. | 2014 | Biophys. J. | pmid:25185549 |
| Fattal DR and Ben-Shaul A | Mean-field calculations of chain packing and conformational statistics in lipid bilayers: comparison with experiments and molecular dynamics studies. | 1994 | Biophys. J. | pmid:7811955 |
| Zhou Z et al. | 15N NMR study of the ionization properties of the influenza virus fusion peptide in zwitterionic phospholipid dispersions. | 2000 | Biophys. J. | pmid:10777737 |
| Arkhipov A et al. | Membrane-bending mechanism of amphiphysin N-BAR domains. | 2009 | Biophys. J. | pmid:19917226 |
| Gasecka A et al. | Quantitative imaging of molecular order in lipid membranes using two-photon fluorescence polarimetry. | 2009 | Biophys. J. | pmid:19917241 |