12-hydroxy-5,8,10-heptadecatrienoic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with 12-hydroxy-5,8,10-heptadecatrienoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Weight Loss | D015431 | 56 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Yue TL et al. | [Effects of anisodamine on the metabolism of arachidonic acid by rat pleural neutrophils]. | 1988 | Yao Xue Xue Bao | pmid:2855772 |
| Yg G et al. | [Effect of Allium cepa L. var. agrogatum Don and Allium macrostemon Bunge on arachidonic acid metabolism]. | 1988 | Yao Xue Xue Bao | pmid:3400480 |
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| Li NY | [Selective inhibitory effects of flufenamic acid on metabolic pathways of arachidonate 5-lipoxygenase and cyclooxygenase]. | 1989 | Sheng Li Ke Xue Jin Zhan | pmid:2561227 |
| Fujimoto Y et al. | High density lipoprotein inhibits platelet 12-lipoxygenase activity. | 1994 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:7827811 |
| John H et al. | Development and review of radioimmunoassay of 12-S-hydroxyheptadecatrienoic acid. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9785378 |
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| Eling T et al. | Separation of prostaglandins, thromboxane, hydroxy fatty acids and arachidonic acid by high pressure liquid chromatography. | 1980 | Prostaglandins Med | pmid:6779300 |
| Vincent JE et al. | Determination of the formation of thromboxane B2 (TxB2), 12L-hydroxy-5,8,10 heptadecatrienoic acid (HHT) and 12L-hydroxy-5,8,10,14 eicosatrienoic acid (HETE) from arachidonic acid and of the TxB2 :HHT, TxB2 :HETE and (TxB2 +HHT) :HETE ratio in human platelets. Possible use in diagnostic purposes. | 1980 | Prostaglandins Med | pmid:7413847 |
| Hall ER et al. | Immobilization of catalytically active thromboxane synthase. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3406040 |
| Sakuma S et al. | Perfluorinated carboxylic acids inhibit cyclooxygenase pathway more potently than 12-lipoxygenase pathway in rat platelets. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20678909 |
| O'Sullivan BP et al. | Reduction of eicosanoid production by essential fatty acid depletion does not attenuate the inflammatory response induced by Pseudomonas aeruginosa pneumonia in rat lung. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1324504 |
| Sakuma S et al. | Effects of daphnodorin A, B and C, new flavans isolated from traditional Chinese medicine, on the 12-lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578153 |
| Fujimoto Y et al. | Comparison of the effects of nitric oxide and peroxynitrite on the 12-lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9774172 |
| Espada CE et al. | Effect of Chia oil (Salvia Hispanica) rich in omega-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17618100 |
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| Stenson WF et al. | Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. | 1981 | Prostaglandins | pmid:6803301 |
| Sadowitz PD et al. | The platelet cyclooxygenase metabolite 12-L-hydroxy-5, 8, 10-hepta-decatrienoic acid (HHT) may modulate primary hemostasis by stimulating prostacyclin production. | 1987 | Prostaglandins | pmid:3124219 |
| Siegel MI et al. | The production of 5-HETE and leukotriene B in rat neutrophils from carrageenan pleural exudates. | 1981 | Prostaglandins | pmid:6259697 |
| Greenwald JE et al. | Argentation thin layer chromatography of arachidonic acid metabolites isolated from human platelets. | 1981 | Prostaglandins | pmid:7208953 |
| Muller M and Sorrell TC | Inhibition of the human platelet cyclooxygenase response by the naturally occurring phenazine derivative, 1-hydroxyphenazine. | 1995 Nov-Dec | Prostaglandins | pmid:8838240 |
| Morrison AR et al. | Thromboxane A2 is the major arachidonic acid metabolite of human cortical hydronephrotic tissue. | 1981 | Prostaglandins | pmid:6894498 |
| She HS et al. | Metabolism of prostaglandin endoperoxide by microsomes from cat lung. | 1981 | Prostaglandins | pmid:6894797 |
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| Vecino AM et al. | Phospholipase A2 activity in platelets of patients with uremia. | 2002 | Platelets | pmid:12487789 |
| Mezei Z et al. | Platelet arachidonate cascade of migraineurs in the interictal phase. | 2000 | Platelets | pmid:10938901 |
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| Abbate R et al. | Activity of dipyrone on intraplatelet arachidonic acid metabolism: an in vitro study. | 1989 Jan-Feb | Pharmacol. Res. | pmid:2726664 |
| Csanyi G et al. | Lack of endothelium-derived hyperpolarizing factor (EDHF) up-regulation in endothelial dysfunction in aorta in diabetic rats. | 2007 Jul-Aug | Pharmacol Rep | pmid:17901574 |
| Csányi G et al. | Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis. | 2008 May-Jun | Pharmacol Rep | pmid:18622059 |
| Stuart MJ and Allen JB | Arachidonic acid metabolism in the neonatal platelet. | 1982 | Pediatrics | pmid:6804924 |
| Graeber JE et al. | Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism. | 1982 | Pediatr. Res. | pmid:6808450 |
| Fujimoto Y et al. | Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide. | 2001 | Nitric Oxide | pmid:11178940 |
| Hamasaki Y and Miyazaki S | [Characterization of 12-L-hydroxy 5, 8, 10-heptadecatrienoic acid produced by rat basophilic leukemia-2H3 cells]. | 1989 | Nippon Ketsueki Gakkai Zasshi | pmid:2618543 |
| Chevy F et al. | A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets. | 1991 | Lipids | pmid:1819690 |
| Dannhardt G and Lehr M | In-vitro evaluation of 5-lipoxygenase and cyclo-oxygenase inhibitors using bovine neutrophils and platelets and HPLC. | 1992 | J. Pharm. Pharmacol. | pmid:1359057 |
| Berdeaux O et al. | Effects of a trans isomer of arachidonic acid on rat platelet aggregation and eicosanoid production. | 1996 | J. Lipid Res. | pmid:8906600 |
| O'Keefe SF et al. | Trans n-3 eicosapentaenoic and docosahexaenoic acid isomers exhibit different inhibitory effects on arachidonic acid metabolism in human platelets compared to the respective cis fatty acids. | 1990 | J. Lipid Res. | pmid:2144870 |
| Matsunobu T et al. | Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. | 2013 | J. Lipid Res. | pmid:24009185 |