12-hydroxy-5,8,10-heptadecatrienoic acid

12-hydroxy-5,8,10-heptadecatrienoic acid is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 466 references associated with 12-hydroxy-5,8,10-heptadecatrienoic acid in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 12-hydroxy-5,8,10-heptadecatrienoic acid

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 12-hydroxy-5,8,10-heptadecatrienoic acid

MeSH term MeSH ID Detail
Uremia D014511 33 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Pleurisy D010998 20 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Seizures D012640 87 associated lipids
Weight Loss D015431 56 associated lipids
Total 6

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All references with 12-hydroxy-5,8,10-heptadecatrienoic acid

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Authors Title Published Journal PubMed Link
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Eling T et al. Separation of prostaglandins, thromboxane, hydroxy fatty acids and arachidonic acid by high pressure liquid chromatography. 1980 Prostaglandins Med pmid:6779300
Vincent JE et al. Determination of the formation of thromboxane B2 (TxB2), 12L-hydroxy-5,8,10 heptadecatrienoic acid (HHT) and 12L-hydroxy-5,8,10,14 eicosatrienoic acid (HETE) from arachidonic acid and of the TxB2 :HHT, TxB2 :HETE and (TxB2 +HHT) :HETE ratio in human platelets. Possible use in diagnostic purposes. 1980 Prostaglandins Med pmid:7413847
Kinoshita K et al. Bioconversion of arachidonic acid in human amnion during pregnancy and labor. 1980 Adv Prostaglandin Thromboxane Res pmid:7376992
Best LC et al. Thromboxane B2 production and lipid peroxidation in human blood platelets. 1980 Adv Prostaglandin Thromboxane Res pmid:7386271
Vincent JE et al. Effect of an inhibitor of TXA2 synthesis and of PGE2 on the formation of 12-L-hydroxy-5,8,10-heptadecatrienoic acid in human platelets. 1980 Adv Prostaglandin Thromboxane Res pmid:7386279
Stenson WF et al. Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. 1981 Prostaglandins pmid:6803301
Siegel MI et al. The production of 5-HETE and leukotriene B in rat neutrophils from carrageenan pleural exudates. 1981 Prostaglandins pmid:6259697
Defreyn G et al. Familial bleeding tendency with partial platelet thromboxane synthetase deficiency: reorientation of cyclic endoperoxide metabolism. 1981 Br. J. Haematol. pmid:6268139
Hall ER and Tai HH Purification of thromboxane synthetase and evidence of two distinct mechanisms for the formation of 12-L-hydroxy-5,8,10-heptadecatrienoic acid by porcine lung microsomes. 1981 Biochim. Biophys. Acta pmid:7197552
Greenwald JE et al. Argentation thin layer chromatography of arachidonic acid metabolites isolated from human platelets. 1981 Prostaglandins pmid:7208953
Morrison AR et al. Thromboxane A2 is the major arachidonic acid metabolite of human cortical hydronephrotic tissue. 1981 Prostaglandins pmid:6894498
She HS et al. Metabolism of prostaglandin endoperoxide by microsomes from cat lung. 1981 Prostaglandins pmid:6894797
Stuart MJ and Allen JB Arachidonic acid metabolism in the neonatal platelet. 1982 Pediatrics pmid:6804924
Powell WS Formation of 6-oxoprostaglandin F1 alpha, 6,15-dioxoprostaglandin F1 alpha, and monohydroxyicosatetraenoic acids from arachidonic acid by fetal calf aorta and ductus arteriosus. 1982 J. Biol. Chem. pmid:6809737
Rao GH et al. Simple method for the separation of monohydroxy fatty acid metabolites of arachidonate metabolism. 1982 J. Chromatogr. pmid:7142327
Graeber JE et al. Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism. 1982 Pediatr. Res. pmid:6808450
Miller JL et al. Arachidonic acid metabolism in guinea pig megakaryocytes. 1982 Biochem. Biophys. Res. Commun. pmid:6812584
Johnsen SA et al. Conversion of arachidonic acid in human maternal and neonatal mononuclear leukocytes. 1983 Immunol. Lett. pmid:6411611
Stuart MJ The effect of irradiation on platelet arachidonic acid metabolism. 1983 Mar-Apr Transfusion pmid:6404019
Driss F et al. Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid. 1984 Thromb. Res. pmid:6098051
Liu Y et al. 12-L-hydroxy-5,8,10-heptadecatrienoic acid (HHT) is an excellent substrate for NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. 1985 Biochem. Biophys. Res. Commun. pmid:4004878
Halenda SP et al. Phorbol esters and oleoyl acetoyl glycerol enhance release of arachidonic acid in platelets stimulated by Ca2+ ionophore A23187. 1985 J. Biol. Chem. pmid:3930496
Kimura Y et al. Effects of stilbene derivatives on arachidonate metabolism in leukocytes. 1985 Biochim. Biophys. Acta pmid:3931689
Hamsten A et al. Shortened megakaryocyte-platelet regeneration time in young survivors of myocardial infarction. 1985 Am. Heart J. pmid:2866703
Zulak IM et al. A fast, nondestructive purification scheme for prostaglandin H2 using a nonaqueous, bonded-phase high-performance liquid chromatography system. 1986 Anal. Biochem. pmid:3085539
Rousson D et al. Acute myocardial infarction: measurement of arachidonate end-products in whole blood as an index of platelet cyclo-oxygenase activity in vivo. 1987 Thromb. Res. pmid:3122356
Sweeney FJ et al. The use of 12-hydroxyheptadecatrienoic acid (HHT) as an HPLC/spectrophotometric marker for cyclooxygenase pathway activity in resident rat peritoneal cells. 1987 Prostaglandins Leukot Med pmid:3033686
Leis HJ et al. Quantitative measurement of 5-, 12-, and 15-hydroxyeicosatetraenoic acid together with 12-hydroxyheptadecatrienoic acid by stable isotope dilution gas chromatography-negative ion chemical ionization-mass spectrometry. 1987 Anal. Biochem. pmid:3300415
Sadowitz PD et al. The platelet cyclooxygenase metabolite 12-L-hydroxy-5, 8, 10-hepta-decatrienoic acid (HHT) may modulate primary hemostasis by stimulating prostacyclin production. 1987 Prostaglandins pmid:3124219
Yue TL et al. [Effects of anisodamine on the metabolism of arachidonic acid by rat pleural neutrophils]. 1988 Yao Xue Xue Bao pmid:2855772
Vericel E et al. Platelets and aging. I--Aggregation, arachidonate metabolism and antioxidant status. 1988 Thromb. Res. pmid:3129819
Yg G et al. [Effect of Allium cepa L. var. agrogatum Don and Allium macrostemon Bunge on arachidonic acid metabolism]. 1988 Yao Xue Xue Bao pmid:3400480
Hall ER et al. Immobilization of catalytically active thromboxane synthase. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3406040
Campbell PB and Tolson TA Modulation of human monocyte leukotactic responsiveness by thromboxane A2 and 12-hydroxyheptadecatrienoic acid (12-HHT). 1988 J. Leukoc. Biol. pmid:3422086
Hecker M and Ullrich V 12(S)-Hydroxy-5,8,10 (Z,E,E)-heptadecatrienoic acid (HHT) is preferentially metabolized to its 12-keto derivative by human erythrocytes in vitro. 1988 Eicosanoids pmid:3272822
Kouzan S et al. Stimulation of arachidonic acid metabolism by adherence of alveolar macrophages to a plastic substrate. Modulation by fetal bovine serum. 1988 Am. Rev. Respir. Dis. pmid:2827547
Hamasaki Y and Miyazaki S [Characterization of 12-L-hydroxy 5, 8, 10-heptadecatrienoic acid produced by rat basophilic leukemia-2H3 cells]. 1989 Nippon Ketsueki Gakkai Zasshi pmid:2618543
Yue TL et al. [Effects of anisodamine on the metabolism of arachidonic acid by washed rat platelets]. 1989 Yao Xue Xue Bao pmid:2618712
Yue TL and Tong L [Effects of dauricine on the metabolism of arachidonic acid in rat pleural neutrophils]. 1989 Zhongguo Yao Li Xue Bao pmid:2558500
Li NY [Selective inhibitory effects of flufenamic acid on metabolic pathways of arachidonate 5-lipoxygenase and cyclooxygenase]. 1989 Sheng Li Ke Xue Jin Zhan pmid:2561227
Guichardant M et al. Metabolism of endogenous arachidonic acid in weakly activated platelets. Absence of leukocyte cooperative products in whole blood. 1989 Eicosanoids pmid:2516743
Tong L and Yue TL [Effect of dauricine on rat and human platelet aggregation and metabolism of arachidonic acid in washed rat platelets]. 1989 Yao Xue Xue Bao pmid:2801142
Tornhamre S et al. Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products. 1989 Eur. J. Pharmacol. pmid:2572437
Engels W et al. Influence of a cytomegalovirus infection on functions and arachidonic acid metabolism of rat peritoneal macrophages. 1989 J. Leukoc. Biol. pmid:2540258
Ozaki Y et al. Correlation of intracellular and extracellular calcium ion concentrations with synergy between 1,2-dioctanoyl-sn-glycerol and ionomycin in platelet arachidonic acid mobilization. 1989 Biochim. Biophys. Acta pmid:2499357
Abbate R et al. Activity of dipyrone on intraplatelet arachidonic acid metabolism: an in vitro study. 1989 Jan-Feb Pharmacol. Res. pmid:2726664
Panosian AG et al. [Action of adaptogens: cucurbitacin R diglucoside as a stimulator of arachidonic acid metabolism in the rat adrenal gland]. 1989 Mar-Apr Probl Endokrinol (Mosk) pmid:2544873
Engels F et al. Modulation of the release of 9-hydroxy-octadecadienoic acid and other fatty acid derived mediators from guinea-pig pulmonary macrophages. 1990 Int. J. Immunopharmacol. pmid:2329013
Hofmann U et al. Measurement of 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid and its metabolite 12-oxo-5Z,8E,10E-heptadecatrienoic acid in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. 1990 Anal. Biochem. pmid:2281869
Beving H et al. Effects on cyclo-oxygenase of low and high dose aspirin. 1990 Thromb. Res. pmid:2122535
O'Keefe SF et al. Trans n-3 eicosapentaenoic and docosahexaenoic acid isomers exhibit different inhibitory effects on arachidonic acid metabolism in human platelets compared to the respective cis fatty acids. 1990 J. Lipid Res. pmid:2144870
Duncan EM and Lloyd JV Interference caused by acid extraction in the study of diacylglycerol in platelets. 1991 Blood Coagul. Fibrinolysis pmid:1893058
Chevy F et al. A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets. 1991 Lipids pmid:1819690
Stenke L et al. Deficient lipoxin synthesis: a novel platelet dysfunction in myeloproliferative disorders with special reference to blastic crisis of chronic myelogenous leukemia. 1991 Blood pmid:1659470
Engels F et al. Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism. 1992 FEBS Lett. pmid:1299626
Tawata M et al. Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice. 1992 Eur. J. Pharmacol. pmid:1555643
O'Sullivan BP et al. Reduction of eicosanoid production by essential fatty acid depletion does not attenuate the inflammatory response induced by Pseudomonas aeruginosa pneumonia in rat lung. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1324504
Pruimboom WM et al. Eicosanoid production by density-defined human peritoneal macrophages during inflammation. 1992 Agents Actions pmid:1332454
Dannhardt G and Lehr M In-vitro evaluation of 5-lipoxygenase and cyclo-oxygenase inhibitors using bovine neutrophils and platelets and HPLC. 1992 J. Pharm. Pharmacol. pmid:1359057
Gecse A and Telegdy G Captopril as a modifier of the arachidonate cascade of rat platelets. 1992 Agents Actions Suppl. pmid:1462859
Zijlstra FJ et al. Species differences in the pattern of eicosanoids produced by inflamed and non-inflamed tissue. 1992 Agents Actions pmid:1442338
Guichardant M et al. Effects of 9, 12, 15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on platelet aggregation. 1992 Thromb. Res. pmid:1636161
Linssen MC et al. Production of arachidonic acid metabolites in adult rat cardiac myocytes, endothelial cells, and fibroblast-like cells. 1993 Am. J. Physiol. pmid:8456996
Yokoyama C et al. Expression of human thromboxane synthase using a baculovirus system. 1993 FEBS Lett. pmid:8436233
Höhl W et al. Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z, 8E, 10E, 12S)-12-hydroxy-5,8,10-heptadecatrienoic acid as substrate. 1993 Eur. J. Biochem. pmid:8508808
Sumiya T et al. Effects of reactive oxygen species on arachidonic acid metabolism in rabbit platelets. 1993 Free Radic. Biol. Med. pmid:8359708
Satoh K et al. Effects of sulfonylurea agents on platelet arachidonic acid metabolism; study on platelet homogenates. 1994 Biochem. Pharmacol. pmid:8093094
Chabannes B et al. Decreased arachidonic acid metabolism in human platelets by autologous neutrophils: possible role of cell adhesion. 1994 Biochem. J. pmid:7516654
Beving H et al. Inter-individual variations of the effect of low dose aspirin regime on platelet cyclooxygenase activity. 1994 Thromb. Res. pmid:8029807
Fujimoto Y et al. High density lipoprotein inhibits platelet 12-lipoxygenase activity. 1994 Res. Commun. Mol. Pathol. Pharmacol. pmid:7827811
Teissier E et al. Interactions of alpha Ni3S2 with guinea pig alveolar macrophages and liberation of inflammatory mediators. 1994 May-Jun J Appl Toxicol pmid:8083477
Kimura Y et al. Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. 1995 J Ethnopharmacol pmid:7776662
Muller M and Sorrell TC Inhibition of the human platelet cyclooxygenase response by the naturally occurring phenazine derivative, 1-hydroxyphenazine. 1995 Nov-Dec Prostaglandins pmid:8838240
Berdeaux O et al. Effects of a trans isomer of arachidonic acid on rat platelet aggregation and eicosanoid production. 1996 J. Lipid Res. pmid:8906600
Rosolowsky M et al. Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites. 1996 Biochim. Biophys. Acta pmid:8652640
Köller M et al. Effect of the PAF-receptor antagonist SM-12502 on human platelets. 1996 Inflammation pmid:8926050
Beving H et al. Abnormally high platelet activity after discontinuation of acetylsalicylic acid treatment. 1996 Blood Coagul. Fibrinolysis pmid:8845467
Tsunomori M et al. 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. 1996 Biochim. Biophys. Acta pmid:8679681
Calzada C et al. Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. 1997 Biochem. J. pmid:9230133
Mezei Z et al. Platelet eicosanoids and the effect of captopril in blood pressure regulation. 1997 Eur. J. Pharmacol. pmid:9527508
Kis B et al. The effect of substance P on the arachidonate cascade of rat platelets. 1997-1998 Acta Physiol Hung pmid:9706302
Ruf A et al. Characterization of the thromboxane synthase pathway product 12-oxoheptadeca-5(Z)-8(E)-10(E)-trienoic acid as a thromboxane A2 receptor antagonist with minimal intrinsic activity. 1998 Br. J. Haematol. pmid:9576182
Sakuma S et al. Effects of daphnodorin A, B and C, new flavans isolated from traditional Chinese medicine, on the 12-lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9578153
Fujimoto Y et al. Comparison of the effects of nitric oxide and peroxynitrite on the 12-lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774172
John H et al. Development and review of radioimmunoassay of 12-S-hydroxyheptadecatrienoic acid. 1998 Prostaglandins Other Lipid Mediat. pmid:9785378
John H and Schlegel W Thermodynamic and structural characterization of cis-trans isomerization of 12-(S)-hydroxy-(5Z, 8E, 10E)-heptadecatrienoic acid by high-performance liquid chromatography and gaschromatography-mass spectrometry. 1998 Chem. Phys. Lipids pmid:11458962
Margalit A et al. Regulation of prostaglandin biosynthesis in vivo by glutathione. 1998 Am. J. Physiol. pmid:9486284
Fujimoto Y et al. Sphingomyelin inhibits platelet 12-lipoxygenase activity. 1999 Eur. J. Pharmacol. pmid:10478636
John H and Schlegel W Determination of the pK(a) of 12-S-hydroxyheptadecatrienoic acid by studies of its vial surface adsorption using high-performance liquid chromatography and liquid scintillation technique. 1999 Chem. Phys. Lipids pmid:11458961
Margalit A et al. Regulation of in vivo prostaglandin biosynthesis by glutathione. 1999 Adv. Exp. Med. Biol. pmid:10667326
Plastaras JP et al. Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. 2000 J. Biol. Chem. pmid:10766802
Camacho M and Vila L Transcellular formation of thromboxane A(2) in mixed incubations of endothelial cells and aspirin-treated platelets strongly depends on the prostaglandin I-synthase activity. 2000 Thromb. Res. pmid:10946089
Mezei Z et al. Platelet arachidonate cascade of migraineurs in the interictal phase. 2000 Platelets pmid:10938901
Fujimoto Y et al. Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide. 2001 Nitric Oxide pmid:11178940
Beck-Speier I et al. Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages. 2001 Environ. Health Perspect. pmid:11544173
Shyue SK et al. Selective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer. 2001 Circulation pmid:11319200
Vecino AM et al. Phospholipase A2 activity in platelets of patients with uremia. 2002 Platelets pmid:12487789