12-hydroxy-5,8,10-heptadecatrienoic acid is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with 12-hydroxy-5,8,10-heptadecatrienoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Uremia | D014511 | 33 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ishii Y et al. | Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins. | 2016 | FASEB J. | pmid:26527063 |
| Liu M et al. | 12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor. | 2014 | J. Exp. Med. | pmid:24821912 |
| Gus-Brautbar Y and Panigrahy D | Time heals all wounds--but 12-HHT is faster. | 2014 | J. Exp. Med. | pmid:24890114 |
| Frömel T et al. | Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques. | 2013 | Basic Res. Cardiol. | pmid:23224081 |
| Matsunaga Y et al. | Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. | 2013 | FASEB J. | pmid:23603839 |
| Matsunobu T et al. | Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand. | 2013 | J. Lipid Res. | pmid:24009185 |
| Fan SY et al. | The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo. | 2012 | J Ethnopharmacol | pmid:21619922 |
| Lee JW et al. | 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. | 2012 | Exp. Mol. Med. | pmid:22391335 |
| Bauer J et al. | Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. | 2011 | Biochem. Pharmacol. | pmid:20933508 |
| Sakuma S et al. | Perfluorinated carboxylic acids inhibit cyclooxygenase pathway more potently than 12-lipoxygenase pathway in rat platelets. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20678909 |
| Koeberle A et al. | Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1. | 2009 | Br. J. Pharmacol. | pmid:19298395 |
| Yasuda D et al. | Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum. | 2009 | FASEB J. | pmid:19126593 |
| Csányi G et al. | Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis. | 2008 May-Jun | Pharmacol Rep | pmid:18622059 |
| Okuno T et al. | 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. | 2008 | J. Exp. Med. | pmid:18378794 |
| Csanyi G et al. | Lack of endothelium-derived hyperpolarizing factor (EDHF) up-regulation in endothelial dysfunction in aorta in diabetic rats. | 2007 Jul-Aug | Pharmacol Rep | pmid:17901574 |
| Espada CE et al. | Effect of Chia oil (Salvia Hispanica) rich in omega-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17618100 |
| Li X et al. | Activation of extracellular signal-regulated kinase by 12-hydroxyheptadecatrienoic acid in prostate cancer PC3 cells. | 2007 | Arch. Biochem. Biophys. | pmid:17880908 |
| Fujimoto Y et al. | Monochloramine potently inhibits arachidonic acid metabolism in rat platelets. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16615995 |
| Pataki I et al. | In vivo effects of isatin on rat platelet eicosanoids. | 2005 | Platelets | pmid:15763895 |
| Forsell PK et al. | Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha. | 2005 | Biochem. Pharmacol. | pmid:16290172 |
| Trebino CE et al. | Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages. | 2005 | J. Biol. Chem. | pmid:15722356 |
| Fujimoto Y et al. | Effects of endocrine disruptors on arachidonic acid metabolism in rabbit platelets. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12781627 |
| Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
| Vecino AM et al. | Phospholipase A2 activity in platelets of patients with uremia. | 2002 | Platelets | pmid:12487789 |
| Fujimoto Y et al. | Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide. | 2001 | Nitric Oxide | pmid:11178940 |
| Beck-Speier I et al. | Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages. | 2001 | Environ. Health Perspect. | pmid:11544173 |
| Shyue SK et al. | Selective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer. | 2001 | Circulation | pmid:11319200 |
| Plastaras JP et al. | Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. | 2000 | J. Biol. Chem. | pmid:10766802 |
| Camacho M and Vila L | Transcellular formation of thromboxane A(2) in mixed incubations of endothelial cells and aspirin-treated platelets strongly depends on the prostaglandin I-synthase activity. | 2000 | Thromb. Res. | pmid:10946089 |
| Mezei Z et al. | Platelet arachidonate cascade of migraineurs in the interictal phase. | 2000 | Platelets | pmid:10938901 |
| Fujimoto Y et al. | Sphingomyelin inhibits platelet 12-lipoxygenase activity. | 1999 | Eur. J. Pharmacol. | pmid:10478636 |
| John H and Schlegel W | Determination of the pK(a) of 12-S-hydroxyheptadecatrienoic acid by studies of its vial surface adsorption using high-performance liquid chromatography and liquid scintillation technique. | 1999 | Chem. Phys. Lipids | pmid:11458961 |
| Margalit A et al. | Regulation of in vivo prostaglandin biosynthesis by glutathione. | 1999 | Adv. Exp. Med. Biol. | pmid:10667326 |
| Ruf A et al. | Characterization of the thromboxane synthase pathway product 12-oxoheptadeca-5(Z)-8(E)-10(E)-trienoic acid as a thromboxane A2 receptor antagonist with minimal intrinsic activity. | 1998 | Br. J. Haematol. | pmid:9576182 |
| Sakuma S et al. | Effects of daphnodorin A, B and C, new flavans isolated from traditional Chinese medicine, on the 12-lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578153 |
| Fujimoto Y et al. | Comparison of the effects of nitric oxide and peroxynitrite on the 12-lipoxygenase and cyclooxygenase metabolism of arachidonic acid in rabbit platelets. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9774172 |
| John H et al. | Development and review of radioimmunoassay of 12-S-hydroxyheptadecatrienoic acid. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9785378 |
| John H and Schlegel W | Thermodynamic and structural characterization of cis-trans isomerization of 12-(S)-hydroxy-(5Z, 8E, 10E)-heptadecatrienoic acid by high-performance liquid chromatography and gaschromatography-mass spectrometry. | 1998 | Chem. Phys. Lipids | pmid:11458962 |
| Margalit A et al. | Regulation of prostaglandin biosynthesis in vivo by glutathione. | 1998 | Am. J. Physiol. | pmid:9486284 |
| Kis B et al. | The effect of substance P on the arachidonate cascade of rat platelets. | 1997-1998 | Acta Physiol Hung | pmid:9706302 |
| Calzada C et al. | Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. | 1997 | Biochem. J. | pmid:9230133 |
| Mezei Z et al. | Platelet eicosanoids and the effect of captopril in blood pressure regulation. | 1997 | Eur. J. Pharmacol. | pmid:9527508 |
| Berdeaux O et al. | Effects of a trans isomer of arachidonic acid on rat platelet aggregation and eicosanoid production. | 1996 | J. Lipid Res. | pmid:8906600 |
| Rosolowsky M et al. | Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites. | 1996 | Biochim. Biophys. Acta | pmid:8652640 |
| Köller M et al. | Effect of the PAF-receptor antagonist SM-12502 on human platelets. | 1996 | Inflammation | pmid:8926050 |
| Beving H et al. | Abnormally high platelet activity after discontinuation of acetylsalicylic acid treatment. | 1996 | Blood Coagul. Fibrinolysis | pmid:8845467 |
| Tsunomori M et al. | 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. | 1996 | Biochim. Biophys. Acta | pmid:8679681 |
| Muller M and Sorrell TC | Inhibition of the human platelet cyclooxygenase response by the naturally occurring phenazine derivative, 1-hydroxyphenazine. | 1995 Nov-Dec | Prostaglandins | pmid:8838240 |
| Kimura Y et al. | Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. | 1995 | J Ethnopharmacol | pmid:7776662 |
| Teissier E et al. | Interactions of alpha Ni3S2 with guinea pig alveolar macrophages and liberation of inflammatory mediators. | 1994 May-Jun | J Appl Toxicol | pmid:8083477 |
| Satoh K et al. | Effects of sulfonylurea agents on platelet arachidonic acid metabolism; study on platelet homogenates. | 1994 | Biochem. Pharmacol. | pmid:8093094 |
| Chabannes B et al. | Decreased arachidonic acid metabolism in human platelets by autologous neutrophils: possible role of cell adhesion. | 1994 | Biochem. J. | pmid:7516654 |
| Beving H et al. | Inter-individual variations of the effect of low dose aspirin regime on platelet cyclooxygenase activity. | 1994 | Thromb. Res. | pmid:8029807 |
| Fujimoto Y et al. | High density lipoprotein inhibits platelet 12-lipoxygenase activity. | 1994 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:7827811 |
| Linssen MC et al. | Production of arachidonic acid metabolites in adult rat cardiac myocytes, endothelial cells, and fibroblast-like cells. | 1993 | Am. J. Physiol. | pmid:8456996 |
| Yokoyama C et al. | Expression of human thromboxane synthase using a baculovirus system. | 1993 | FEBS Lett. | pmid:8436233 |
| Höhl W et al. | Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z, 8E, 10E, 12S)-12-hydroxy-5,8,10-heptadecatrienoic acid as substrate. | 1993 | Eur. J. Biochem. | pmid:8508808 |
| Sumiya T et al. | Effects of reactive oxygen species on arachidonic acid metabolism in rabbit platelets. | 1993 | Free Radic. Biol. Med. | pmid:8359708 |
| Engels F et al. | Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism. | 1992 | FEBS Lett. | pmid:1299626 |
| Tawata M et al. | Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice. | 1992 | Eur. J. Pharmacol. | pmid:1555643 |
| O'Sullivan BP et al. | Reduction of eicosanoid production by essential fatty acid depletion does not attenuate the inflammatory response induced by Pseudomonas aeruginosa pneumonia in rat lung. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1324504 |
| Pruimboom WM et al. | Eicosanoid production by density-defined human peritoneal macrophages during inflammation. | 1992 | Agents Actions | pmid:1332454 |
| Dannhardt G and Lehr M | In-vitro evaluation of 5-lipoxygenase and cyclo-oxygenase inhibitors using bovine neutrophils and platelets and HPLC. | 1992 | J. Pharm. Pharmacol. | pmid:1359057 |
| Gecse A and Telegdy G | Captopril as a modifier of the arachidonate cascade of rat platelets. | 1992 | Agents Actions Suppl. | pmid:1462859 |
| Zijlstra FJ et al. | Species differences in the pattern of eicosanoids produced by inflamed and non-inflamed tissue. | 1992 | Agents Actions | pmid:1442338 |
| Guichardant M et al. | Effects of 9, 12, 15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on platelet aggregation. | 1992 | Thromb. Res. | pmid:1636161 |
| Duncan EM and Lloyd JV | Interference caused by acid extraction in the study of diacylglycerol in platelets. | 1991 | Blood Coagul. Fibrinolysis | pmid:1893058 |
| Chevy F et al. | A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets. | 1991 | Lipids | pmid:1819690 |
| Stenke L et al. | Deficient lipoxin synthesis: a novel platelet dysfunction in myeloproliferative disorders with special reference to blastic crisis of chronic myelogenous leukemia. | 1991 | Blood | pmid:1659470 |
| Engels F et al. | Modulation of the release of 9-hydroxy-octadecadienoic acid and other fatty acid derived mediators from guinea-pig pulmonary macrophages. | 1990 | Int. J. Immunopharmacol. | pmid:2329013 |
| Hofmann U et al. | Measurement of 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid and its metabolite 12-oxo-5Z,8E,10E-heptadecatrienoic acid in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. | 1990 | Anal. Biochem. | pmid:2281869 |
| Beving H et al. | Effects on cyclo-oxygenase of low and high dose aspirin. | 1990 | Thromb. Res. | pmid:2122535 |
| O'Keefe SF et al. | Trans n-3 eicosapentaenoic and docosahexaenoic acid isomers exhibit different inhibitory effects on arachidonic acid metabolism in human platelets compared to the respective cis fatty acids. | 1990 | J. Lipid Res. | pmid:2144870 |
| Panosian AG et al. | [Action of adaptogens: cucurbitacin R diglucoside as a stimulator of arachidonic acid metabolism in the rat adrenal gland]. | 1989 Mar-Apr | Probl Endokrinol (Mosk) | pmid:2544873 |
| Abbate R et al. | Activity of dipyrone on intraplatelet arachidonic acid metabolism: an in vitro study. | 1989 Jan-Feb | Pharmacol. Res. | pmid:2726664 |
| Hamasaki Y and Miyazaki S | [Characterization of 12-L-hydroxy 5, 8, 10-heptadecatrienoic acid produced by rat basophilic leukemia-2H3 cells]. | 1989 | Nippon Ketsueki Gakkai Zasshi | pmid:2618543 |
| Yue TL et al. | [Effects of anisodamine on the metabolism of arachidonic acid by washed rat platelets]. | 1989 | Yao Xue Xue Bao | pmid:2618712 |
| Yue TL and Tong L | [Effects of dauricine on the metabolism of arachidonic acid in rat pleural neutrophils]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2558500 |
| Li NY | [Selective inhibitory effects of flufenamic acid on metabolic pathways of arachidonate 5-lipoxygenase and cyclooxygenase]. | 1989 | Sheng Li Ke Xue Jin Zhan | pmid:2561227 |
| Guichardant M et al. | Metabolism of endogenous arachidonic acid in weakly activated platelets. Absence of leukocyte cooperative products in whole blood. | 1989 | Eicosanoids | pmid:2516743 |
| Tong L and Yue TL | [Effect of dauricine on rat and human platelet aggregation and metabolism of arachidonic acid in washed rat platelets]. | 1989 | Yao Xue Xue Bao | pmid:2801142 |
| Tornhamre S et al. | Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products. | 1989 | Eur. J. Pharmacol. | pmid:2572437 |
| Engels W et al. | Influence of a cytomegalovirus infection on functions and arachidonic acid metabolism of rat peritoneal macrophages. | 1989 | J. Leukoc. Biol. | pmid:2540258 |
| Ozaki Y et al. | Correlation of intracellular and extracellular calcium ion concentrations with synergy between 1,2-dioctanoyl-sn-glycerol and ionomycin in platelet arachidonic acid mobilization. | 1989 | Biochim. Biophys. Acta | pmid:2499357 |
| Yue TL et al. | [Effects of anisodamine on the metabolism of arachidonic acid by rat pleural neutrophils]. | 1988 | Yao Xue Xue Bao | pmid:2855772 |
| Vericel E et al. | Platelets and aging. I--Aggregation, arachidonate metabolism and antioxidant status. | 1988 | Thromb. Res. | pmid:3129819 |
| Yg G et al. | [Effect of Allium cepa L. var. agrogatum Don and Allium macrostemon Bunge on arachidonic acid metabolism]. | 1988 | Yao Xue Xue Bao | pmid:3400480 |
| Hall ER et al. | Immobilization of catalytically active thromboxane synthase. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3406040 |
| Campbell PB and Tolson TA | Modulation of human monocyte leukotactic responsiveness by thromboxane A2 and 12-hydroxyheptadecatrienoic acid (12-HHT). | 1988 | J. Leukoc. Biol. | pmid:3422086 |
| Hecker M and Ullrich V | 12(S)-Hydroxy-5,8,10 (Z,E,E)-heptadecatrienoic acid (HHT) is preferentially metabolized to its 12-keto derivative by human erythrocytes in vitro. | 1988 | Eicosanoids | pmid:3272822 |
| Kouzan S et al. | Stimulation of arachidonic acid metabolism by adherence of alveolar macrophages to a plastic substrate. Modulation by fetal bovine serum. | 1988 | Am. Rev. Respir. Dis. | pmid:2827547 |
| Rousson D et al. | Acute myocardial infarction: measurement of arachidonate end-products in whole blood as an index of platelet cyclo-oxygenase activity in vivo. | 1987 | Thromb. Res. | pmid:3122356 |
| Sweeney FJ et al. | The use of 12-hydroxyheptadecatrienoic acid (HHT) as an HPLC/spectrophotometric marker for cyclooxygenase pathway activity in resident rat peritoneal cells. | 1987 | Prostaglandins Leukot Med | pmid:3033686 |
| Leis HJ et al. | Quantitative measurement of 5-, 12-, and 15-hydroxyeicosatetraenoic acid together with 12-hydroxyheptadecatrienoic acid by stable isotope dilution gas chromatography-negative ion chemical ionization-mass spectrometry. | 1987 | Anal. Biochem. | pmid:3300415 |
| Sadowitz PD et al. | The platelet cyclooxygenase metabolite 12-L-hydroxy-5, 8, 10-hepta-decatrienoic acid (HHT) may modulate primary hemostasis by stimulating prostacyclin production. | 1987 | Prostaglandins | pmid:3124219 |
| Zulak IM et al. | A fast, nondestructive purification scheme for prostaglandin H2 using a nonaqueous, bonded-phase high-performance liquid chromatography system. | 1986 | Anal. Biochem. | pmid:3085539 |
| Liu Y et al. | 12-L-hydroxy-5,8,10-heptadecatrienoic acid (HHT) is an excellent substrate for NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004878 |
| Halenda SP et al. | Phorbol esters and oleoyl acetoyl glycerol enhance release of arachidonic acid in platelets stimulated by Ca2+ ionophore A23187. | 1985 | J. Biol. Chem. | pmid:3930496 |
| Kimura Y et al. | Effects of stilbene derivatives on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3931689 |
| Hamsten A et al. | Shortened megakaryocyte-platelet regeneration time in young survivors of myocardial infarction. | 1985 | Am. Heart J. | pmid:2866703 |